| Reference # |
Patent
Status |
Category |
Description |
| 2009-003 |
Pending
|
Medical Devices |
Laparoscopic Surgical Stapler
To overcome problems with confined spaces within the pelvic region when performing laparoscopic procedures ...
|
| 2009-012 |
Pending
|
Therapeutics |
Andenoviral Hexon Modifications to Reduce Liver Damage, Increase Virus Dosage, and Evade Neutralizing Antibodies
Blood factors bind hypervariable loops in adenvirus hexon and redirect adenovirus to the liver where it can ...
|
| 2009-017 |
Pending
|
Research Tools |
Method for Synthesis of Very Long Chain Fatty Acids
Very long chain polyunsaturated fatty acids (VLPUFAs) are present in the human retina and play an important ...
|
| 2009-034 |
Pending
|
Therapeutics |
Nanoparticle-Based Delivery of Therapeutic Peptides / Proteins for the Treatment of Human Disease (Also incorporates 2009-032 & 2009-033)
Enzyme replacement therapy (ERT) has been shown to be safe and effective for the treatment of several ...
|
| 2009-054 |
Pending
|
Software |
Mayo Clinic Digital Library of Clinical Cases
A software tool developed to archive case reports, videos, endoscopic images, radiological images, pathology ...
|
| 2009-100 |
Pending
|
Software |
Computerized Breast Cancer Tool
Computerized education tool for breast cancer - http://mayoweb.mayo/imdg/web_BCed/launch_bced.htm...
|
| 2009-118 |
Pending
|
Medical Devices |
Postierior Percutaneous Facet Screws
The device is a screw which is inserted in a percutaneous fashion posteriorly across the cervical facet joint ...
|
| 2009-125 |
None
|
Research Tools |
Homozygous Constitutive Mouse Model for Wild-Type TDP-43
This invention includes the development of a homozygous transgenic mouse model expressing wild-type human ...
|
| 2009-126 |
None
|
Research Tools |
Inducible Mouse Models for TDP-43
This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding ...
|
| 2009-132 |
None
|
Research Tools |
Anti-MDC1 Monoclonal Antibody
A monoclonal antibody to MDC1, a key mediator of DNA damage response. ...
|
| 2009-161 |
Pending
|
Research Tools |
Tools to Improve Multidisciplinary Management of Anemia for End Stage Renal Disease (ESRD) Patients
This expert system optimizes the delivery of erythropoiesis stimulating agents (ESAs) to treat anemia in ...
|
| 2009-175 |
Pending
|
Electronic Devices |
Peritrode Minimally Invasive Cirmcumferential Peripheral Nerve Stimulation Electrode, Anchoring System and Placement Assist Device
An eight contact electrode placed "through the needle"via ultrasound visual guidance. The electrode is able ...
|
| 2009-175 |
Pending
|
Electronic Devices |
Peritrode Minimally Invasive Cirmcumferential Peripheral Nerve Stimulation Electrode, Anchoring System and Placement Assist Device
An eight contact electrode placed "through the needle"via ultrasound visual guidance. The electrode is able ...
|
| 2009-176 |
None
|
Software |
Clinical Studies Database
The CRU Database application is a web based application designed to capture pertinent clinic study data to ...
|
| 2009-189 |
None
|
Diagnostics |
Antibody Panel for Detection of Orthopaedic Implant Infection
We have invented a technique for rapidly removing biofilms from the surface of explanted orthopaedic implants ...
|
| 2009-207 |
Pending
|
Therapeutics |
3D Transgene as an Inhibitor of Viral Infection
Mice that express the RNA-depleted RNA polymerase, 3D, from Theiler's murine encephalomyelitis virus (TMEV) ...
|
| 2009-211 |
Pending
|
Diagnostics |
USP10 as a Therapeutic Target
In cancer cells with wild-type p53, USP10 acts as a tumor suppressor, and activating USP10 appears to be a ...
|
| 2009-217 |
Pending
|
Therapeutics |
Bile Acid Binding with Colesevelam Alone or in Combination with Measurement of 7alphaC4 in the Treatment of Functional Diarrhea, Chronic Diarrhea of Unknown Etiology, Post-Transplant Diarrhea, and Irritable Bowel Syndrome with Diarrhea
Patients with chronic diarrhea of unknown origin are suboptimally treated. We have identified a fasting ...
|
| 2009-221 |
Pending
|
Diagnostics |
FKBP5 (FKBP51) can Function as a Biomarker for Prediction of Response to Gencitabine, AraC, Paclitaxel, Dovetaxel, SN38 and Etoposide as well as a Biomarker for Tumorgenesis
We found that FKBP5 and (FKBP51), an immunophilin that functions as a scaffold protein between AKT and AKT ...
|
| 2009-266 |
Pending
|
Undetermined |
Medical Student Well-Being Index
Distress is pervasive among medical students, has serious personal and professional ramifications, and often ...
|
| 2009-294 |
Pending
|
Research Tools |
Cytokine Response Profiling in Rheumatoid Arthritis
Current practice in the management of Rheumatoid Arthritis (RA) involves assessing the progression or ...
|
| 2009-296 |
Pending
|
Research Tools |
A Mouse Model of Recessive Polycystic Kidney Disease
Mouse model of recessive polycystic Kidney Disease (ARPKD)...
|
| 2009-338 |
Pending
|
Therapeutics |
Suppression of Amyloid Deposition in Alzheimer's Disease by Manipulating the Interleukin-6 Pathway on Microglia and Astrocytes
IL-6 enhances the phenotypic and immunnological activation of glia, do not prompt amyloid beta accumulation ...
|
| 2009-355 |
Pending
|
Undetermined |
A Discrete Event Simulation Model to Evaluate Operational Performance of a Colonoscopy Suite
Software used to evaluate operational performance of a colonoscopy suite....
|
| 2009-362 |
Pending
|
Research Tools |
Immunodetection of Covalent Topoisomerase I-DNA Complexes
A number of approved and investigational anticancer drugs target the enzyme topoisomerase I (topo I). ...
|
| 2008-001 |
Pending
|
Therapeutics |
Single Cycle Replicating Adenovirus Vectors
Adenoviruses are used for gene therapy, vaccines, and cancer killing. For gene therapy and vaccine they are ...
|
| 2008-014 |
Pending
|
Medical Devices |
Nitinol Curve: Intramedullary Fixation for Small Bone Fractures
A fracture fixation system particularly useful for bones of the hand and foot is disclosed. The system uses ...
|
| 2008-016 |
None
|
Research Tools |
Anti-SINA/SIAH Monoclonal Antibodies & Related Know-How
Four mouse anti-SINA/SIAH monoclonal antibodies are available for licensing. Details are as follows. Two ...
|
| 2008-019 |
Pending
|
Therapeutics |
Human Monoclonal Antibodies Against Amyloid Beta Protein as a Therapeutic Agent for Alzheimer's Disease
Alzheimer's disease (AD) is the most common form of elderly dementia, and currently no effective treatment is ...
|
| 2008-021 |
Pending
|
Diagnostics |
Quantitative Imaging of Chemical Composition Using Dual-Energy, Dual-Source CT: Three Material Decompostion Using Reconstructed Images
Quantitative imaging of chemical composition may be accomplished using dual energy CT. However, dual energy ...
|
| 2008-022 |
Pending
|
Diagnostics |
Quantitative Imaging of Chemical Compositions Using Dual-Energy, Dual-Source CT: Two Material Decomposition Using Reconstructed Images
Quantitative imaging of chemical composition in patients may be a very useful diagnostic technique for a ...
|
| 2008-035 |
None
|
Research Tools |
53BPI-Deficient Mice
Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression.
See Ward et ...
|
| 2008-036 |
Pending
|
Medical Devices |
Artifact Reduction System (ARS) for Ultrasound Coblation Procedures
Coblation devices are currently being employed to débride diseased tendons and other soft tissue via open and ...
|
| 2008-037 |
Pending
|
Medical Devices |
Ultrasound Guided Balloon Dilator (UGBD)
The UGBD is a versatile medical device utilized to percutaneously dilate soft tissue regions in the body. ...
|
| 2008-059 |
|
Medical Devices |
Tissue Block Transport Container
Clear plastic container used to transport up to 4 (1" square pathology tissue blocks) via suggested method of ...
|
| 2008-073 |
Pending
|
Diagnostics |
Methods for the Detection of MicroRNAs as Biomarkers for Neurological Disorders
The invention relates to the detection of microRNA molecules and microRNA genotypic sequences as biomarkers ...
|
| 2008-076 |
Pending
|
Diagnostics |
CYP2D6 Metabolism as a Predictor of Tamoxifen Resistance in HER-2 Positive Breast Cancer
Tamoxifen is a commonly used agent in the management of breast cancer. Tamoxifen is a prodrug, converted to ...
|
| 2008-077 |
None
|
Software |
Headache Section Data Entry, Storage and Managment Software Application
This software application increases quality, ease and efficiency in a Clinic Subspecialty Practice by: 1. ...
|
| 2008-084 |
None
|
Research Tools |
Talley Bowel Disease Questionaire (BDQ)
Validated bowel disease questionaire...
|
| 2008-098 |
None
|
Research Tools |
GFP-Centrin2 Expression Vector
A long-standing puzzle in cell biology is the question of how cells generate one and only one new centrosome ...
|
| 2008-103 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-38 (MM43-14.1.1)
Monoclonal antibodies were raised to human Abeta 1-38. The peptide used to immunize was Abeta 35-40. This ...
|
| 2008-104 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Rodent Abeta 1-16
Monoclonal antibodies were raised to rodent Abeta 1-16. The peptide used to immuize was rodent Abeta 1-16. ...
|
| 2008-114 |
None
|
Research Tools |
Caveolin-1 Antibodies
Purified antibodies from rabbit serum that recognize, specifically, the caveolin-1 protein. This specific set ...
|
| 2008-115 |
None
|
Research Tools |
Eps15 Mid/C-Terminal Antibodies
Purified antibodies from rabbit serum that specifically recognize the Eps15 protein at two different and ...
|
| 2008-120 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-40 (MM32-13.1.1)
Monoclonal antibodies were raised to human Abeta 1-40. The peptide used to immunize was Abeta 35-40. This ...
|
| 2008-121 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-16 (MM27-33.1.1)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This ...
|
| 2008-122 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-42 (MM26-4.1.3)
Monoclonal antibodies were raised to human Abeta1-42. The peptide used to immunize was Abeta 35-42. ...
|
| 2008-123 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-16 (Ab-9)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This ...
|
| 2008-124 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-16 (Fibrillar Ab1-42; AB42-5.)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was fibrillar Abeta 1-42. ...
|
| 2008-125 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-42 (MM26-2.1.3)
Monoclonal antibodies were raised to human Abeta 1-42. The peptide used to immunize was Abeta 35-42. This ...
|
| 2008-126 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-42 (MM40-21.3.1)
Monoclonal antibodies were raised to human Abeta1-42. The peptide used to immunize was Abeta 35-42. This ...
|
| 2008-128 |
Pending
|
Therapeutics |
Gastroduodenal Balloon Tube for Pancreatic Hypothermia with Nasal Piece and Jejunal Feedling Tube Extension
There is no treatment for acute pancreatitis which affects 250,000 people in the USA annually. Peritoneal ...
|
| 2008-139 |
None
|
Research Tools |
Mouse Monoclonal Antibody Recognizing Abeta1-16, Ab9 Isotype IgAk, Ab9-A, Clone Ab9 15E7.17.10
Mouse monoclonal Ab9-A, isotype A of the original Ab9 mouse monoclonal made to human amyloid beta 1-16, was ...
|
| 2008-140 |
Pending
|
Diagnostics |
Elderly at Risk (EAR) Index
As the population in the United States and the world ages, it is becoming increasingly important for ...
|
| 2008-141 |
Pending
|
Diagnostics |
A Technique for Projection Space Reconstruction of Dual Source, Dual Energy Spiral CT Data
Dual energy CT performed using dual source scanner geometry is limited to dual energy algorithms that operate ...
|
| 2008-142 |
Pending
|
Therapeutics |
HSV-2 Peptides for Stimulation of Cytotoxic T Lymphocytes
Optimal immunization with an antigen vaccine is achieved when both the antigen and the adjuvant are delivered ...
|
| 2008-144 |
Pending
|
Therapeutics |
Vaccines Against Antibiotics Resistance Genes
Antibiotics fail when pathogens acquire genes that confer resistance to these drugs. This invention proposes ...
|
| 2008-155 |
Pending
|
Therapeutics |
Prolonged Localized Hypothermia as a Treatment for Pancreatic Cancer
Pancreatic cancer (affecting 39,000 people annualy in the USA and 40,000 in Europe) typically presents at a ...
|
| 2008-163 |
None
|
Research Tools |
Inducible Tau Mice Expressing Human 4RON Tau With the P301L Mutation (termed iP301L)
These mice conditionally express the human tau cDNA (4RON isoform) containing the FTDP-17 mutation (P301L) in ...
|
| 2008-181 |
Pending
|
Research Tools |
Targeting Adenovirus Using Factor X Fusion Proteins
Blood factors including factor X (fX) bind the hypervariable regions of Ad hexon protein and retarget the ...
|
| 2008-191 |
Pending
|
Diagnostics |
Acetaminophen Toxicity Pharmocogenomics
Acetaminophen hepatotoxicity is a major cause of acute liver failure in Western societies. Acetaminophen must ...
|
| 2008-192 |
Pending
|
Medical Devices |
Translocation Inhibition Needle
Endoscopic ultrasound guided fine needle aspiration (EUS FNA) systems have been designed to prevent or ...
|
| 2008-195 |
Pending
|
Research Tools |
Generation of iPS Cells for Preclinical and Clinical Studies
Retroviral or lentiviral vector-mediated stable introduction of some stem cell-associated genes can reprogram ...
|
| 2008-214 |
Pending
|
Electronic Devices |
Signal Termination Block
The present invention is a circuit block used to condition and
sample a variety of electrical signals in ...
|
| 2008-233 |
None
|
Research Tools |
Polyclonal Antibody Against Human Frataxin Protein
This is a polyclonal antibody raised in a rabbit against the mature form of human frataxin (amino acid ...
|
| 2008-239 |
None
|
Medical Devices |
Transfer Tray
The transfer tray conceived is MRI and CT compatible and is extremely strong, to accommodate even the largest ...
|
| 2008-261 |
None
|
Research Tools |
LRRK2 G2019S Knock-In Mice
Mice in which the endogenous murine leucine-rich repeat kinase 2 gene (LRRK2; NCBI accession NM_025730 and ...
|
| 2008-263 |
Pending
|
Medical Devices |
MRI Compatible Knee Positioning Device
A positioning device has been created for MRI diagnostic imaging of the knee joint. The device makes it ...
|
| 2008-268 |
Pending
|
Medical Devices |
Tendon or Ligament (Soft Tissue) Attachment Device(s)
Methods and devices are disclosed for the attachment of a soft tissue structure (e.g., tendon or ligament) to ...
|
| 2008-277 |
None
|
Research Tools |
Human Anaplastic Thyroid Carcinoma Cell Lines
Anaplastic thyroid carcinoma (ATC) is one of the deadliest cancers with lethality of >99% and survival ...
|
| 2008-346 |
None
|
Research Tools |
Monoclonal Antibody Recognizing Abeta 1-16 (AB42-2)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Fibrillar Abeta ...
|
| 2008-347 |
Pending
|
Therapeutics |
Genetic Biomarker for Prediction of Response to Radiation Therapy
Genetic biomarkers for the prediction to response to radiation therapy have been discovered and are being ...
|
| 2008-375 |
Pending
|
Therapeutics |
Delayed Release Sodium Chenodeoxycholate Accelerates Colonic Transit and Increases Stool Frequency and Stool Consistency in Humans: A Novel Approach to Treating Constipation in Humans
The body produces bile salts in the liver, and these recirculate between the liver and intestine every day. ...
|
| 2007-004 |
Pending
|
Software |
Anti-coagulation Clinic - Web Application
Problem Definition and Descriptions
" AMC requires a centralized, secure, system to track patient ...
|
| 2007-005 |
Pending
|
Diagnostics |
Human Catechol O-Methyltransferase Gene Polymorphisms and Risk for Breast Cancer
Two single nucleotide polymorphism (SNPs) within the COMT gene have been identified as potential biomarkers ...
|
| 2007-006 |
Pending
|
Software |
Axial Centerline Following for Display of CT Colonography Images
This invention consists of a novel display technique for CT colonography data. It is based on automatic ...
|
| 2007-007 |
Pending
|
Software |
Oblique Centerline Following for Display of CT Colonography Images
This invention consists of a novel display technique for CT colonography data. It is based on automatic ...
|
| 2007-008 |
Pending
|
Software |
Electronic Stool Subtraction Using Quadratic Regression and Intelligent Morphology
CT colonography (CTC) is being extensively studied for its potential value in colon examinations. Like ...
|
| 2007-009 |
Pending
|
Software |
Simultaneous Dual Window/Level Settings for Improved Viewing of CT Colongraphy Images
Currently, radiologists interpreting CT colonography exams find it most efficient to view colons primarily in ...
|
| 2007-012 |
None
|
Diagnostics |
Monoclonal Anti-Eosinophil Peroxidase (EPX) Antibody and a Diagnostic Histology Test for Detecting the Presence of Eosinophils and Eosinophil Degranulation in Clinical Biopsies
The past 20 years have witnessed an unprecedented increase in eosinophil-associated diseases such as allergy, ...
|
| 2007-016 |
None
|
Research Tools |
Transgenic Mouse Expressing P1 Artificial Chromosome (PAC) Containing the Entire Human Alpha-Synuclein (SNCA) Gene
Tansgenic mouse that over-expresses the human alpha-synuclein gene, under the control of its endogenous human ...
|
| 2007-021 |
Pending
|
Diagnostics |
A Highly-Sensitive Plasma Von Willebrand Factor: Ristocetin Cofactor Activity Assay by Flow Cytometry
The von Willebrand factor ristocetin co-factor activity (VWF:RCo) is routinely used in screening of patients ...
|
| 2007-027 |
None
|
Research Tools |
LRRK2 BAC Transgenic Mice: A Model of Parkinsonism
Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2)....
|
| 2007-030 |
Pending
|
Therapeutics |
Peptide Transfection Reagents for Non-Covalently Delivering Proteins and DNA into Human Mitochondria
Novel peptides have been designed to noncovalently bind proteins or nucleic acids and transport them into ...
|
| 2007-032 |
Pending
|
Research Tools |
Novel Cytochrome P450 (CYP) 2D6 Gene and CYP2D7 Pseudogene Arrangements and Tests for Detection of These Newly Discovered Gene Arrangements
The CYP2D6 gene makes a protein that metabolizes drugs. This gene is highly variable. It can have different ...
|
| 2007-033 |
Pending
|
Research Tools |
Determination of the Phase of Duplicated CYP2D6 Alleles
These methods enable determination of the phase of duplicated of CYP2D6 alleles using an allele specific ...
|
| 2007-039 |
None
|
Medical Devices |
Adherent Thoracolumbar Plate and Rod Spine Stabilization Implant
A spinal implant composed of a locking screw-plate and rod used to stabilize the anterior human spine. An ...
|
| 2007-042 |
Pending
|
Therapeutics |
Abeta42 Lowering Agents that Inhibit Abeta Aggregation
Aggregation of Abeta42 is proposed to cause Alzheimers disease. Lowering Abeta42 production and preventing ...
|
| 2007-043 |
Pending
|
Therapeutics |
Enodgenous Wild Type BRI Peptides as Potential Therapeutic Compound for the Treatment and Prevention of AD
Amyloid beta peptide (Abeta) accumulation within senile plaques, cerebral blood vessels walls, and diffuse ...
|
| 2007-050 |
None
|
Research Tools |
Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from AL Amyloidsis
The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell ...
|
| 2007-051 |
None
|
Medical Devices |
Distal Radius Shadow Fixation System with PEEK-OPTIMA (TM)
The Shadow Fixation System allows open reduction and internal fixation of distal radius fractures utilizing ...
|
| 2007-052 |
None
|
Medical Devices |
Olecranon and Radial Head Shadow Fixation Systems with PEEK-OPTIMA (TM)
The Shadow Fixation System allows open reduction internal fixation of olecranon and radial head fractures ...
|
| 2007-064 |
Pending
|
Research Tools |
Human Pharmacogenomic Variation Cell Line Panel
Mayo Clinic researchers have identified a small set of genes for which expression correlates strongly with ...
|
| 2007-069 |
None
|
Medical Devices |
Previous Proximal Row Carpectomy Wrist Fusion Plate
Proximal row carpectomy is frequently a successful surgery, alleviating pain from the arthritic joint. ...
|
| 2007-077 |
Pending
|
Therapeutics |
Selective and Irreversible Inhibitors of Insect AChEs for Pest Control: a New-Generation of Human-Safe and Effective Pesticides
This invention relates to invertebrate and insect-specific acetylcholinesterase (AChE) inhibitors, as well as ...
|
| 2007-088 |
Pending
|
Medical Devices |
Multi-Planar EUS Transducer
This echoendoscope would include a transducer (of variable shapes) with multiple crystal of which some ...
|
| 2007-089 |
Pending
|
Medical Devices |
Dual Channel Bi-Directional Echoendoscope
This instrument allows passage of accessories through two separate channels. The opening to one channel is ...
|
| 2007-089 |
Pending
|
Medical Devices |
Dual Channel Bi-Directional Echoendoscope
This instrument allows passage of accessories through two separate channels. The opening to one channel is ...
|
| 2007-094 |
Pending
|
Medical Devices |
Mucosal Biopsy Mount
Unique system including a mounting system to place mucosal biopsy specimens in a preferred orientation and to ...
|
| 2007-100 |
Pending
|
Diagnostics |
Phase Offset and Time Delay Correction on Magnetic Resonance Spectroscopy Data
A mathematical method is described that is used to estimate the inherent phase offsets and timing differences ...
|
| 2007-103 |
Pending
|
Research Tools |
In Vitro and In Vivo Models of TDP-43 and TDP-43 as Biomarker for Neurodegenerative Diseases
The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for ...
|
| 2007-104 |
Pending
|
Research Tools |
Lrrk2 Antibodies (Revised 6-19-2007)
Human leucine-rich repeat kinase 2 (Lrrk2) antibodies, raised to sequence peptides in rabbits and used to ...
|
| 2007-119 |
None
|
Research Tools |
TDP-43 Overexpressing Mice: A Transgenic Model of Dementia
TDP-43 is a major protein constituent of ubiquitin-positive inclusions in patients with dementia, including ...
|
| 2007-120 |
None
|
Research Tools |
mTau Overexpressing Mice: A Transgenic Model of Dementia
Accumulation of tau in neurofibrillary tangles is an important pathological indicator of several ...
|
| 2007-132 |
None
|
Electronic Devices |
Automated Multi-Port Vector Network Analysis PWB Test System
The test system will automate multi-port VNA S-parameters measurements of printed wiring boards (PWB). The ...
|
| 2007-134 |
None
|
Diagnostics |
Breast Cancer Risk Prediction Model
A multifeature model, based in our benign breast disease cohort, to predict risk of subsequent breast cancer. ...
|
| 2007-135 |
Pending
|
Software |
Rapid Electrical Link Analysis Technique for Simulating Electrical Signals Through Transmission Media Characterized by Scattering Parameters
This technique is a software program which permits very rapid simulation of electrical signals through ...
|
| 2007-138 |
Pending
|
Medical Devices |
X-Compression/Cross Compression PIP and MCP Joint Fusion System
The purpose of this fusion system is to provide the hand surgeon, orthopedic surgeon and plastic surgeon with ...
|
| 2007-141 |
None
|
Medical Devices |
Intraoperative Surgical Warming Table
This invention is composed of a radiotranslucent frame with hollow tubework throughout that allows for the ...
|
| 2007-142 |
Pending
|
Diagnostics |
Device to Measure Thrombin Generation in Blood and Plasma
Measurements of blood clotting in the laboratory are essential in diagnosis and management of bleeding ...
|
| 2007-154 |
Pending
|
Software |
Automated Vector Network Analyzer (VNA) Calibration Technique for Automated Testing Environments
This invention is a technique that enables two or four port vector network analyzers (VNAs) to be probe-tip ...
|
| 2007-155 |
None
|
Research Tools |
Plasmodium Falciparum Signal Peptide Peptidase cDNA Plasmid Constructs
These are circular DNA plasmid constructs that encode for a gene called signal peptide peptidase. The gene ...
|
| 2007-166 |
None
|
Research Tools |
Detection of Cytochrome P450 (CYP) 2D7-CYP2D6 Recombinant Genes
This invention describes a method that allows for the detection of the CYP2D7-CYP2D6 recombinant gene. This ...
|
| 2007-172 |
Pending
|
Research Tools |
Method for Estimating Diversity of Receptors Expressed by Thymus-Derived Lymphocytes
Thymus-derived (T) lymphocytes are important for controlling infections and cancer. The ability to carry out ...
|
| 2007-175 |
None
|
Medical Devices |
Pressure Ulcer Prevention Bed
Inspired by the contoured shape of a satellite dish, the Pressure Ulcer Prevention bed matches the natural ...
|
| 2007-177 |
None
|
Diagnostics |
Automated Vortexing Sonicator for Dislodging Bacteria from Biofilms
An interdisiplinary group at Mayo Clinic has demonstrated a procedure for sampling the bacteria resident in ...
|
| 2007-187 |
Pending
|
Therapeutics |
CD38 as a Target for Obesity, Metabolic Syndrome Related Disorders, and Dementia (Including Alzheimer's Disease)
The protein CD38 is an enzyme that regulates cellular levels of nicotinamide adenine dinucleotide (NAD), ...
|
| 2007-193 |
Pending
|
Diagnostics |
Non-Linear Blending of Dual-Energy Computed Tomography
The invention combines information from two different energies to create a greatly improved visualization ...
|
| 2007-219 |
Pending
|
Diagnostics |
A Clinical Test for the Identification of Amyloid Proteins in Fat Aspirate Biopsy Specimens by Mass Spectrometry
The management of systemic amyloidosis relies on the treatment of the underlying etiology and differs ...
|
| 2007-222 |
Pending
|
Therapeutics |
IgM-Mediated Method of Receptor Clustering and Cell Modulation
Mayo researchers have developed a method for using an IgM or another multivalent molecule to cluster and cap ...
|
| 2007-229 |
Pending
|
Diagnostics |
Quantitation of Lobular Involution for Breast Cancer Risk Prediction
Our group was the first to describe that the process of age-related involution (or regression) of the ...
|
| 2007-230 |
None
|
Research Tools |
Human IAPP Knock-In Mouse
We have replace the mouse islet amyloid polypeptide (IAPP, amylin) gene with the human IAPP gene. Human IAPP ...
|
| 2007-235 |
None
|
Research Tools |
Cell Line Established from Ileal and Rectal Carcinoid Tumors
Carcinoids of the intestine are the most common gastrointestinal carcinoid tumors. Therapeutic options to ...
|
| 2007-236 |
Pending
|
Diagnostics |
Cytidine Analog Pharmacogenomics
Mayo Clinic researchers have discovered polymorphisms that correlate with sensitivity to radiation therapy ...
|
| 2007-246 |
None
|
Research Tools |
Monoclonal Antibody 4F3
4F3 is a mouse monoclonal anitbody against the protein Hsp90. It binds specifically to Hsp 90 from avian ...
|
| 2007-248 |
Pending
|
Therapeutics |
MHC Class II Epitope Modification Strategies for Improved Generation of Antigen-Specific CD4 T Cells
Mayo Clinic researchers have developed epitope modifications that improve the immunogenicity of peptides by ...
|
| 2007-258 |
None
|
Research Tools |
Antibody to GALC
Monoclonal antibodies to GALC for use for disease research and as a histological lysosomal marker. ...
|
| 2007-259 |
None
|
Research Tools |
Generation of EBV-Transformed B-Cell Lines from CVID Patients with TACI Mutation
We have generated 2 B-cell lines from 2 individual CVID patients who have a specific mutation in the TACI ...
|
| 2007-268 |
None
|
Medical Devices |
Shoulder Strengthening Kit
Elastic shoulder strengthening device with exercise manual. ...
|
| 2007-288 |
None
|
Research Tools |
LRRK2 Knock Out Mice
Mice in which the endogenous leucine-rich repeat kinase 2 gene (LRRK2) has been ablated. Exon 41 has been ...
|
| 2007-300 |
None
|
Research Tools |
Recombinant Mature Form of Human Frataxin Protein
Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by a deficiency of frataxin, a ...
|
| 2007-306 |
Pending
|
Diagnostics |
Microvesicle Phenotype as a Diagnostic
Microvesicles/microparticles are fragments of cellular membranes which are released into the peripheral ...
|
| 2007-323 |
None
|
Research Tools |
AbS1 a Monoclonal Antibody to GCUNC45
This is a monoclonal antibody against GCUNC45 (General Cell UNC45) also called SMAP-1 which has sequence ...
|
| 2007-324 |
None
|
Research Tools |
Monoclonal Antibody to tsp23 (transcript like p23)
This is a monoclonal antibody, produced in mice, to the human protein tsp23 which has sequence similarity to ...
|
| 2007-325 |
None
|
Research Tools |
Monoclonal Antibody JJ6
JJ6 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for ...
|
| 2007-326 |
None
|
Research Tools |
Monoclonal Antibody JJ12
JJ12 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for ...
|
| 2007-327 |
None
|
Research Tools |
High-Throughput Cell-Based Assay for Lrrk2 Activity
Leucine-rich repeat kinase 2 (lrrk2) exits as a dimer, and with associated proteins probably forms a higher ...
|
| 2007-330 |
None
|
Research Tools |
iLRRK2 Wild-Type and Mutant (G2019S) Transgenic Mice
We created mice that contain human LRRK2 cDNA encoding either the wild-type or G2019S mutant form of the gene ...
|
| 2006-042 |
None
|
Therapeutics |
A System for Monitoring Ligand-dependent and Ligand-independent Androgen Receptor Activity
The androgen receptor is a protein that mediates androgen signaling in the body. In prostate cells, for ...
|
| 2006-055 |
None
|
Research Tools |
Human Breast Cancer Cell Lines
We have developed unique breast cancer cell lines with inducible estrogen receptor isoforms (alpha and beta) ...
|
| 2006-059 |
None
|
Research Tools |
Antibodies Toward Intracellular Signaling Molecules: WAVE2, Ev1, VASP, HS1, STIM, CIN85 and TUBA
Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA ...
|
| 2006-067 |
Pending
|
Diagnostics |
A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q in Human Oligodendrogliomas and Predicts and Better Prognosis of These Patients
Combined deletions of the chromosomes 1p and 19q arms are associated with glioma of oligodendroglial lineage. ...
|
| 2006-073 |
None
|
Software |
CITES: Cosmology Inspired Tissue Engineering Scaffolds
We disclose a method which mimics the primordial processes which initiated the morphogenesis of the now ...
|
| 2006-079 |
Pending
|
Therapeutics |
Tranvesical Peritoneoscopy and Retroperitoneoscopy: The Urinary Tract as a Portal for Natural Orfice Surgery
A new approach to minimally invasive surgery involving access to the peritoneal cavity and retroperitoneum ...
|
| 2006-086 |
Pending
|
Therapeutics |
Programming the Polarity of the Immune Response in an Anitgen Independent Fashion
The acquired immune response is focused on specific antigens. Typically these antigens are discrete entities ...
|
| 2006-087 |
Pending
|
Therapeutics |
Prostaglandin-Pathway Gene Therapy
We have developed a gene therapy technology protocol that delivers genes for key enzymes in the prostaglandin ...
|
| 2006-100 |
None
|
Research Tools |
Assays for Detection of Malarial Signal Peptide Peptidase (SPP) Activity and Use in Identifying Novel Anti-Malarial Drugs
We have identified and synthesized a gene encoding a novel drug target in the malarial parasite (Plasmodium ...
|
| 2006-104 |
Pending
|
Diagnostics |
Soluble Prostate Diagnostic/Early Detection Biomarkers
A discriminating panel of genes has been identified that may be used for early detection of prostate cancer. ...
|
| 2006-107 |
Pending
|
Diagnostics |
Clinical Applications of Serum HtrA1 as Markers for Pre-Eclampsia, Osteoarthritis, and Cardiovascular Diseases
We have generated polyclonal antibodies against HtrA1, and established an ELISA protocol that successfully ...
|
| 2006-115 |
Pending
|
Therapeutics |
Pan Anti-beta Amyloid scFVs, Anti-beta Amyloid scFVs Specific for Abeta-40 and Abeta-42 and Methods for Their Delivery to Treat or Prevent Alzheimer's Disease
Accumulation of Abeta in the brain of patients who suffer from Alzheimer?s disease (AD) triggers a complex ...
|
| 2006-123 |
Pending
|
Therapeutics |
Delivery of Biologically Active Antibodies into Human Cells by a Non-Covalently Attached Naturally Occurring Peptide Moiety
Novel peptides have been designed to noncovalently bind proteins or nucleic acids and transport them into ...
|
| 2006-130 |
Pending
|
Diagnostics |
Role of Progranulin in Neurodegenerative Disease
Frontotemporal dementia (FTD) is the second most common cause of dementia in people under 65 years. A large ...
|
| 2006-137 |
Pending
|
Research Tools |
A Novel Systems Biology Approach to Identify Subtle Disease Including Prediabetes Mellitus
A method has been developed for assessing an inter-dependent biological system wherein said methods comprise ...
|
| 2006-149 |
Pending
|
Diagnostics |
Molecular Markers for Biological Response to PPARgamma Agonists
Peroxisomal proliferating activated receptor (PPARgamma) agonists are ligands that bind to PPARgamma, a ...
|
| 2006-159 |
Pending
|
Therapeutics |
ABC-NP - - An Aquaretic and Natriuretic Peptide Without Vasodilatory Properties
The natriuretic peptide family consists of natural hormones involved in the maintenance of fluid and sodium ...
|
| 2006-161 |
Pending
|
Diagnostics |
Gene Can Predict Aggressiveness of Prostate Cancer
Mayo Clinic researchers have identified a gene panel that correlates with systemic progression and death ...
|
| 2006-162 |
Pending
|
Diagnostics |
Proliferation (Cell Cycle) Related Genes Can Predict Aggressiveness of Prostate Cancer
A set of prognostics markers for PCa has been identified using novel bioinformatics algorithms which analyze ...
|
| 2006-179 |
Pending
|
Diagnostics |
Predictive Biomarkers for Parkinson's Disease
We explored an available whole-genome association dataset to identify single nucleotide polymorphisms within ...
|
| 2006-189 |
Pending
|
Diagnostics |
Markers That Can Predict Aggressiveness of Prostate Cancer
A set of prognostics markers for PCa has been identified using novel bioinformatics algorithms which analyze ...
|
| 2006-191 |
None
|
Medical Devices |
Cement Heat Management Device
This device is designed to extract heat during cement polymerization. The device consists of any ...
|
| 2006-194 |
None
|
Diagnostics |
Genetic Polymorphisms in the Human Serotonin Transporter (SLC6A4) Gene in Caucasian, African American, Han Chinese, and Mexican American Populations (Revised June 2007)
The SLC6A4 gene (also referred to as HTT, 5HTT, OCD1, SERT, 5-HTT, and hSERT) encodes an integral membrane ...
|
| 2006-202 |
Pending
|
Diagnostics |
Novel Cytochrome P450 (CYP) 2D6 Gene and CYP2D7 Pseudogene Arrangement and Tests for Detection of These Newly Discovered Gene Arrangements
The CYP2D6 gene makes a protein that metabolizes drugs. This gene is highly variable. It can have different ...
|
| 2006-231 |
None
|
Research Tools |
Polyclonal Antibodies to the CRAC Regulators Orail and STIM1
Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) ...
|
| 2006-241 |
Pending
|
Therapeutics |
Anti-Amyloid scFVs and Methods for Their Delivery to Treat or Prevent Alzheimer's Disease
Numerous pathological conditions including Alzheimer's Disease (AD) are associated with the deposition of ...
|
| 2006-243 |
None
|
Therapeutics |
Mayo Clinic Nicotine Depedence Education Program: Customized Workshops for Health-Care Professionals
A training program to teach health-care professionals how to effectively treat patients who use tobacco. The ...
|
| 2006-244 |
None
|
Therapeutics |
Your Path to Smokeless Tobacco Freedom Patient Manual, Facilitator's Guide, Illustrations, and DVD
Your Path to Smokeless Tobacco Freedom (Your Path) MC6013-01, is a new intervention booklet for patients who ...
|
| 2006-245 |
Pending
|
Electronic Devices |
High Frequency Differential Test Probe for Tight, Compound, Geometries
This differential test probe was designed to meet the requirements of an automated test system. It has ...
|
| 2006-260 |
Pending
|
Software |
Algorithm for Identification of Regions of Change in Three Dimensional Magnetic Resonance Brain Images
The algorithm examines serial three dimensional magnetic resonance brain image data and identifies regions ...
|
| 2006-268 |
Pending
|
Diagnostics |
Expression of Osteogenic Proteins by Circulating Endothelial Precursor Cells as a Diagnostic Test for Vascular Disease
Aortic valve stenosis (AVS) is one of the most common valvular heart diseases. Recent studies have ...
|
| 2006-271 |
Pending
|
Diagnostics |
Phase-Locked Loop Operation of Rotating X-Ray Tube CT System to Reduce the Impact of Partial Reconstruction Orientation Artifacts
For CT Systems with rotating x-ray tubes (all systems commercially-manufactured at this time), the best ...
|
| 2006-279 |
Pending
|
Medical Devices |
Peripheral Oxistimulator
The purpose of this invention is to prevent sudden unexpected death of hospitalized patients, or people at ...
|
| 2006-290 |
Pending
|
Diagnostics |
B7-H3 as a Marker and Target for Cancer Diagnosis, Prognostication, Tumor Vasculature and Therapy
Expression of B7-H3 on the cell surface of tumor cells and tumor-associated vasculature is greatly increased ...
|
| 2006-297 |
Pending
|
Diagnostics |
Clinical Applications of Serum HtrA1 for Atherosclerosis, Coronary Artery Disease, and Myocardial Infarction
We have developed assay systems to detect serum HtrA1 levels, protease activity, and HtrA1 polymorphisms in ...
|
| 2006-299 |
Pending
|
Diagnostics |
Clinical Applications of Serum HtrA1 and Its Activity as Markers for Pre-eclampsia
We have developed assay systems to detect serum HtrA1 levels and its protease activity in clinical samples ...
|
| 2005-008 |
Pending
|
Electronic Devices |
Automatic Energy-Efficient Bathroom Exhaust Fan Control
The proposed invention turns on the bathroom exhaust fan automatically when someone takes a shower. A ...
|
| 2005-014 |
None
|
Research Tools |
Purified Rho Family GTP-binding Proteins
Proteins of the Rho family of GTP-binding proteins regulate multiple cellular phenomenon. There are 17 ...
|
| 2005-016 |
None
|
Research Tools |
rTg4510 Mouse Model of Tauopathy
These transgenic mice have regulatable tau expression and profound neurofibrillary pathology, ...
|
| 2005-017 |
|
Diagnostics |
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
This invention provides methods and materials related to the measurement of TPMT enzymatic activity in ...
|
| 2005-022 |
Pending
|
Software |
Electronic Stool Subtraction Algorithm for CT Colonography Without Bowel Preparation
CT colonography (CTC) offers advantages for colon examinations such as lower risk and less patient ...
|
| 2005-023 |
None
|
Software |
Intraoperative 3D Seed Localization and Dose Analysis in Prostate Brachytherapy
A synergistic integration of two novel algorithmic procedures into a software program for accurate, rapid 3D ...
|
| 2005-026 |
|
Diagnostics |
Self-Contained Semi-Active Cooling Mechanism for Very High Power Density Integrated Circuits and Electronic Modules Using a Reversible Endothermic Chemical Reaction
This invention is a completely self-contained and encapsulated "package" into which a high power integrated ...
|
| 2005-031 |
Pending
|
Research Tools |
Mouse Anti-Human Caspase 8 p41 Monoclonal Antibody
A monoclonal antibody raised in a mouse specifically directed against the C-terminal end of the human protein ...
|
| 2005-044 |
Pending
|
Medical Devices |
Saphenous Vein Clipping and Injection System for Use in Duplex Guided Extraluminal Endoscopic Saphenofemoral Junction Clipping with Retrograde Foam Sclerotherapy
The proposed technology is a simpler and safer method for treating varicose veins of the lower extremities. ...
|
| 2005-048 |
Pending
|
Therapeutics |
Use of Chaetocin and Related Compounds as Cancer Therapeutics
Chaetocin, a previously identified fungal byproduct, was found to kill cancer cells at low nanomolar drug ...
|
| 2005-055 |
Pending
|
Medical Devices |
Anterior Adherent Thoracolumbar Spine Plate
This implant is a fixation device, shaped in the form of a plate for use in the fixation and stabilization of ...
|
| 2005-059 |
Pending
|
Diagnostics |
Genetic Test Predicting Brain Aneurysm Rupture
Mayo Clinic researchers have developed a novel genetic test that predicts the rupture of brain aneurysm. The ...
|
| 2005-060 |
Pending
|
Diagnostics |
Mayo's Older Americans Normative Studies (MOANS)
Age-specific normative data was acquired for people above age 55 on a series of commonly used cognitive ...
|
| 2005-060 |
Pending
|
Diagnostics |
Mayo's Older Americans Normative Studies (MOANS)
Age-specific normative data was acquired for people above age 55 on a series of commonly used cognitive ...
|
| 2005-072 |
|
Diagnostics |
Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired ...
|
| 2005-107 |
None
|
Research Tools |
Stably Transfected Cell Lines Expressing APPwt or Alkaline Phosphatase-APP105 Fusion that Produce Extremely High Levels of Abeta42
These cell lines express a protein (APP) that is cleaved to form the Amyloid beta protein (Abeta) deposited ...
|
| 2005-108 |
Pending
|
Therapeutics |
Non-Abeta Based Amyloid Vaccines: Alternative Strategies to Promote Generic Anti-Amyloid Responses to Treat Alzheimer's Disease and Other Human Amyloidoses
Aggregation and accumulation of amyloid b protein (Ab) plays a pivotal role in the development of Alzheimers ...
|
| 2005-112 |
None
|
Therapeutics |
My Path to a Smoke-Free Future - An Interactive Patient Manual
An interactive patient manual to assist the health care provider in delivering an effective intervention to ...
|
| 2005-115 |
None
|
Medical Devices |
Device for Intracorporeal Vascular Exit and Reentry
Frequently in medical practice there is a need for devices to access tissues that may be difficult to reach. ...
|
| 2005-123 |
Pending
|
Therapeutics |
RHIGM12 Recombinant Antibody
This invention relates to an antibody that can bind to and cross-link B7-DC polybeptides on the surface of a ...
|
| 2005-124 |
|
Diagnostics |
Functionally Relevant, Common Mutations in the Human Sulfotransferase 1A1 (SULT 1A1) Gene
Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a ...
|
| 2005-127 |
None
|
Research Tools |
Antibodies to Isoforms of HP-1 and SP-1
Antibodies to various isoforms of HP-1 and SP-1.
...
|
| 2005-131 |
None
|
Therapeutics |
Facilitator's Guide and DVD for
A guide for the use of the patient intervention manual: "My Path to a Smoke Free Future". It contains ...
|
| 2005-136 |
Pending
|
Medical Devices |
Semi-constrained 1st Carpometacarpal Implant Arthroplasty
This device is used to treat a painful thumb base joint (1st CMC joint) from arthritis. It is composed of ...
|
| 2005-141 |
Pending
|
Therapeutics |
Combination of Phosphodiesterase V Inhibition and Natriuretic Peptides for the Treatment of Cardiovascular and Renal Diseases
Combination of 2 types of drugs, phosphodiesterase V inhibitors and natriuretic peptides, to treat heart and ...
|
| 2005-143 |
None
|
Medical Devices |
Phased Array Designed for Torso Imaging
4/8 channel phased array coil designed for abdominal imaging....
|
| 2005-144 |
None
|
Medical Devices |
Phased Array Designed for Brachial Plexus Nerve Imaging at 1.5 or 3T MRI
4/8 or more channel array designed to image left, right, or bilateral brachial plexus nerves at 1.5T or 3T....
|
| 2005-145 |
None
|
Medical Devices |
Phased Array Receive Only Coil Designed for Leg Imaging
4/8 or more channel receive only array designed for long bone imaging at 1.5 or 3T....
|
| 2005-146 |
None
|
Medical Devices |
Hand Phased Array Coil
4 or 8 channel receive only phased array coil used for hand imaging in MRI at 1.5T and 3T
...
|
| 2005-147 |
None
|
Medical Devices |
Phased Array Receiver Coil Designed for Arm Imaging
4/8 or more channel receive only array designed for arm, elbow, extremity imaging
...
|
| 2005-156 |
|
Diagnostics |
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed ...
|
| 2005-165 |
Pending
|
Therapeutics |
Protease Inhibitors as Immune Adjuvants
The use of HIV protease inhibitors in HIV negative patients increases naive T cell production, which may be ...
|
| 2005-172 |
Pending
|
Therapeutics |
Small-Molecule Antidotes to Botulinum Neurotoxins Serotype A
Serotype selective and nonpeptidic inhibitors of botulinum neurotoxin serotype A (BoNTA) have been developed. ...
|
| 2005-174 |
None
|
Diagnostics |
Major Basic Protein Homolog (MBP2): A Specific Human Eosinophil Marker
Eosinophils are blood leukocytes that are characteristically associated with allergic reactions. For example, ...
|
| 2005-183 |
Pending
|
Medical Devices |
Temporomandibular Joint Fossa-Eminence Metal Prosthesis
A metal onlay implant surgically placed in the temporomandibular joint fossa/eminence (temporal bone) ...
|
| 2005-204 |
Pending
|
Research Tools |
Analytical Reconstruction of Unobserved Ensemble Signals in Biomedical Systems
The invention is a network of coupled equations with deterministic and stochastic features designed to ...
|
| 2005-210 |
Pending
|
Therapeutics |
Endogenous Agonist Mechanism of Action of Class B GPCRs, Key to Small Molecule Drug Development
We have identified a novel molecular mechanism of action of Class B GPCRs, a family that includes important ...
|
| 2005-211 |
Pending
|
Diagnostics |
Discovery of a Novel Spliceoform of the Secretin Receptor
Mayo Clinic researchers identified a novel abnormal spliceoform of the secretin receptor in pancreatic and ...
|
| 2005-215 |
Pending
|
Therapeutics |
Long Acting Atrial Natriuretic Peptide (LA-ANP)
The natriuretic peptide family consists of natural hormones involved in the maintenance of fluid and sodium ...
|
| 2005-231 |
None
|
Research Tools |
Prostate Marker Validation Database
Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a ...
|
| 2005-235 |
None
|
Diagnostics |
A Diagnostic Test for Chronic Rhinosinusitis Using Fungus Specific IgG
A diagnostic test for chronic rhinosinusitis using fungus specific IgG. Fungus specific IgG, specifically ...
|
| 2005-237 |
|
Therapeutics |
Alternaria Antigen
A protein from the fungus alternaria which induces recruitment and activation of eosinophils.
...
|
| 2005-247 |
None
|
Research Tools |
MAPT (tau) cDNA Clones in pCDNA 3.1
MAPT (tau) is a protein involved in regulating the structure and function of nerve cells. The clones contain ...
|
| 2005-255 |
None
|
Research Tools |
pCT26, pFP93, pCT26sin
FIV vector components: transfer vectors (pCT26, pCT26sin) and packaging constructe (pFP93).
...
|
| 2005-277 |
None
|
Therapeutics |
Administration of Low Doses of Natriuretic Peptides to Improve Left Ventricular Remodeling after Myocardial Infarction
After a heart attack, the heart tries to repair itself and undergoes changes in its shape, structure and ...
|
| 2005-287 |
Pending
|
Medical Devices |
A Non-Invasive 24-Hour Intraocular Pressure Monitor
This device is designed to monitor intraocular (eye) pressure over a 24 to 48 hour period, awake and asleep, ...
|
| 2005-293 |
None
|
Research Tools |
Anti-Abeta38 Selective Monoclonal Antibody
This antibody selectively recognizes the 38 amino acid from the amyloid beta peptide....
|
| 2005-305 |
Pending
|
Diagnostics |
Assessing Outcomes for Breast Cancer Patients Treated with Tamoxifen
In the adjuvant treatment of estrogen receptor (ER) positive breast cancer, hormonal therapy reduces the risk ...
|
| 2005-315 |
Pending
|
Diagnostics |
Measurement of Circulating DHEA Levels for the Determination of Histological Severity of Non-alcoholic Fatty Liver Disease
The severity of non-alcoholic fatty liver disease (NAFLD) can be determined with a high degree of accuracy ...
|
| 2005-316 |
None
|
Research Tools |
Ly9 (CD229) Knock Out Mice
These mice do not express the gene for CD229.
...
|
| 2004-002 |
None
|
Medical Devices |
Suture-Mediated Closure Devices
This device serves to close body cavities deep to the skin surface through suture closure. The device can be ...
|
| 2004-004 |
Pending
|
Therapeutics |
Utility of PLVAP for Early Detection, Prognostic Prediction and Therapy of Liver and Other Cancers
Mayo Clinic researchers have produced antibodies against the protein product of a gene that is overexpressed ...
|
| 2004-011 |
|
Therapeutics |
Discovery and Identification of Naturally Processed and Presented HLA Class II Measles Vaccine Virus Peptides
Two measles vaccine virus-derived peptides, from the nucleoprotein (N peptide) and Phosphoprotein P peptide). ...
|
| 2004-012 |
|
Electronic Devices |
Differential Signal Termination and Sampling Blocks
There are a variety of devices being developed to significantly improve the testing, characterization, and ...
|
| 2004-020 |
None
|
Software |
Interactive and Efficient Cell Counter and Analyzer Program (C-CAP)
The CCAP program accurately and efficiently counts and analyzes cells in microscope images. A user ...
|
| 2004-022 |
None
|
Research Tools |
Genetically Modified Mice Susceptible to Pathogens Infection
Mice expressing human CD46 with human-like tissue specificity and efficiency. For additional information, ...
|
| 2004-023 |
|
Software |
Prior Knowledge-Based Rapid Predicted Preview of Multiple Contract Magnetic Resonance Images Derived from a Single Time Budgeted Acquisition
This invention presents a method for producing multiple MR images with different contrast from a single image ...
|
| 2004-027 |
Pending
|
Software |
Techniques to Rate the Validity of Multiple Methods to Process Multi-dimensional Data
To accomplish a given computational task, a number of algorithmic and heuristic approaches can be implemented ...
|
| 2004-055 |
None
|
Software |
Robust Fast Automatic and Parameter Free Skull Stripping of MRI T2-Data
This invention performs a robust, fast and fully automatic parameterization of T2 images into an intensity ...
|
| 2004-056 |
None
|
Software |
High Resolution Three Dimensional Talairach Labels for Human Brain Mapping
This disclosure provides a way to improve the Talairach Labeling scheme that allows labelings to be reported ...
|
| 2004-062 |
None
|
Research Tools |
Osteoblast with Estrogen Receptor Isoform Homodimers and Heterodimers (alpha & beta)
We have developed osteosarcoma cell lines (U2OS) which express both the ER-alpha and ER-beta isoforms and ...
|
| 2004-068 |
Pending
|
Therapeutics |
Methods and Materials for Treating Digestive Motility Disorders
Methods and materials have been disclosed to increase the number of ICC (interstitial cells of Cajal) within ...
|
| 2004-084 |
|
Software |
A Method for Repeated, Rapid Fabrication of Enhanced, Porous, Tissue Engineered Scaffolds
Tissue engineering attempts to address the widening gap between the demand and supply of organ and tissue ...
|
| 2004-085 |
|
Software |
Space Optimal Unit Cell Based Tissue Engineering Scaffolds
Tissue engineering scaffolds are biomimetic "trellis-like" structures which, on implantation and integration, ...
|
| 2004-105 |
Pending
|
Medical Devices |
Detection of Blood Flow Using Emitted Light Absorption
This invention is related to detection of blood pressure, blood flow and heart rhythm abnormalities ...
|
| 2004-108 |
None
|
Research Tools |
51KO Mouse Line
The invention is a mouse line in which we disrupted the gene for FKBP51, a protein component of steroid ...
|
| 2004-109 |
None
|
Research Tools |
52KO Mouse Line
This invention is a mouse line in which we disrupted the gene for FKBP52, a protein component of steroid ...
|
| 2004-133 |
None
|
Research Tools |
Advanced FIV Vector System
A highly engineered FIV vector system useful for delivering genes to cells....
|
| 2004-139 |
Pending
|
Diagnostics |
In vivo Visualization of Alzheimer's Amyloid Plaques without a Contrast Agent
One of the cardinal pathologic features of Alzheimer's disease (AD) is formation of senile or amyloid, ...
|
| 2004-152 |
Pending
|
Therapeutics |
Method of Preventing the Formation of Antibodies in Patients Undergoing Successive Treatments with Therapeutic Antibodies
This invention consists of methods and materials for reducing a mammal?s ability to produce antibodies ...
|
| 2004-153 |
Pending
|
Diagnostics |
Detection of Circulating Tumor Cells Carrying the BRAF V599E Mutation
A diagnostic test for highly sensitive detection of circulating tumor cells that contain the B-RAF V599E gene ...
|
| 2004-154 |
None
|
Research Tools |
GALV.fus Gene
Expression of GALV-fuse gene in tumor cells causes them to fuse with their nontransfected neighbors forming a ...
|
| 2004-159 |
None
|
Diagnostics |
Use of Beta Atrial Natriuretic Peptide as a Screening Biomarker for the Detection of Systolic Left Ventricular Dysfunction and as a Co-Marker with BNP to Detect and Evaluate Heart Failure
The heart releases a peptide called atrial natriuretic peptide (ANP). In heart failure, an abnormal form of ...
|
| 2004-181 |
Pending
|
Research Tools |
Method of Demonstrating the Presence of Fungi in Human Body Fluids
A research tool/method to detect the presence of fungal organisms in human body fluids, particularly from ...
|
| 2004-185 |
Pending
|
Diagnostics |
Identification of Mutations in PARK8, a Locus for Familial Parkinson's Disease
Discovery of the genetic cause of clinical, late-onset (typical) Parkinson's disease in multiple families ...
|
| 2004-199 |
None
|
Diagnostics |
Using Resonance of Artery for Estimation of Arterial Elastic Modulus
It has long been recognized that a high percentage of all cardiovascular disease is associated with a ...
|
| 2004-224 |
Pending
|
Therapeutics |
Novel Anti-SARS Drugs: Small-Molecule Inhibitors of SARS Chymotrypsin-Like Cysteine Proteinase
Through in silico screening and NMR spectroscopic studies, we have discovered a group of drug-like molecules ...
|
| 2004-225 |
Pending
|
Diagnostics |
Prognostic and Diagnostic Tests for Clear Cell Renal Carcinoma
Gene Expression profiling was used to identify a set of genes that are associated with the progression of ...
|
| 2004-231 |
|
Software |
Efficient Digital Synthesis of Waveforms Based on Periodic Functions
The present invention details a substantial implementation improvement for a broad class of Direct Digital ...
|
| 2004-237 |
|
Diagnostics |
Detection of Shear Waves Using Pulse Echo Ultrasound with Kalman Filtering
The present invention detects the harmonic motion of vibro-acoustography using pulse echo ultrasound and ...
|
| 2004-244 |
|
Diagnostics |
Measuring Vitamin D2 and D3 using online extraction and Liquid Chromatography Tandem Mass Spectrometry
Deuterated stable isotope (d3-25-hydroxyvitamin D) is added to a 0.2-mL plasma sample as internal standard. ...
|
| 2004-245 |
Pending
|
Diagnostics |
Multi-beam Radiation Force Generator for Selective Excitation of Vibrational Modes in Objects
The method developed allows selective excitation of an object using the interference of sonic beams. As an ...
|
| 2004-247 |
None
|
Software |
Adaptive Piece-wise Registration for Automated Fusion of Point Cloud Coordinates and Anatomic Volume Images
We have developed a robust, automated point-cloud to surface registration using piece-wise adaptive matching ...
|
| 2004-252 |
Pending
|
Medical Devices |
Fallopian Tube Ostia Location and Marking Device
Device that uses methylene blue to mark tubal ostia enabling location of fallopian tube ostia after ...
|
| 2004-268 |
Pending
|
Therapeutics |
Somatostatin Analogs as Potential Therapeutic Treatment of Hepatic Polycystic Disease
Preclinical data suggests that somatostatin analogs may be useful in treating PKD....
|
| 2004-271 |
None
|
Software |
3D Image Processing for Whole-Bone Integrity Measurement and Analysis
The Biomedical Imaging Resource working with the Endocrine Research Unit has developed a unique and powerful ...
|
| 2004-273 |
|
Diagnostics |
Human Glutathione S-transferase Omega 2 (GSTO2) Genetic Polymorphisms
GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide ...
|
| 2004-274 |
Pending
|
Diagnostics |
Human Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1 (HSD3 B1) Genetic Polymorphisms
Substrates include pregnenolone, 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA) and ...
|
| 2004-284 |
Pending
|
Therapeutics |
Inhibitors of Excision Repair as a Therapeutic to Prevent DNA Amplification Events
We have found that onset of neuronal toxicity in HD (Huntington's) may arise from cellular expansion of ...
|
| 2004-286 |
|
Electronic Devices |
Packaging for High Power Integrated Circuits Using Supercritical Fluid
This invention is a completely self-contained and encapsulated "package" into which a high power integrated ...
|
| 2004-291 |
|
Diagnostics |
Identification of a Novel LRRK2 Mutation, 6055G>A (G2019S), Linked to Autosomal Dominant Parkinsonism in Families from Several European Populations
Pathogenic mutations of the Leucine-Rich Repeat Kinase 2 (LRRK2) enzyme are recognized as the most frequent ...
|
| 2003-023 |
None
|
Diagnostics |
Apparatus and Means to Measure Vessel Stiffness
Ultrasonic radiation pressure is used to induce surface waves in the wall of a vessel. The speed and ...
|
| 2003-028 |
None
|
Medical Devices |
Wire-less MRI Coils
This invention uses optical or RF means to transfer the MRI coil signal from the coil to the scanner reciever ...
|
| 2003-032 |
|
Therapeutics |
Prevention and Intervention in Allergic Asthma Using B7-DC Cross-linking Antibody
Mayo Clinic researchers have developed a human monoclonal antibody that crosslinks the B7-DC receptor on ...
|
| 2003-047 |
|
Research Tools |
Mouse Model of Glucose Intolerance and Role of Myosin Heavy Chain in Glucose Intolerance
Mayo Clinic researchers have developed a novel transgenic mouse model that exhibits symptoms of glucose ...
|
| 2003-071 |
None
|
Research Tools |
Doxycycline-inducible Estrogen Receptor-alpha and -beta Human U2OS Osteosarcoma Cell Lines
These cells allow the investigator to examine the effects of estrogen receptor (ER)-alpha or ER-beta on the ...
|
| 2003-089 |
Pending
|
Therapeutics |
Complexed Peptide and Adjuvant for Improved Vaccines
We have shown that peptides presented by major histocompatibility complex (MHC) class I molecules can be ...
|
| 2003-107 |
None
|
Research Tools |
Use of Specific Estrogen-regulated Genes in U2OS-ERa, U2OS-ERb, and U2OS-ERa/b Osteoblasts as Markers
We have conducted microarray chip analysis of estrogen-regulated genes in the U2OS0ERa, -ERb, and -ERa/b ...
|
| 2003-108 |
|
Research Tools |
Unique Phenotype of TIEG Knockout Mice
We have developed mice which contain a disruption in a nucleic acid encoding TIEG. The mice develop cardiac ...
|
| 2003-119 |
|
Medical Devices |
A Novel Lead Delivery Device
A device to facilitate epicardial placement of permanent pacing leads, ablation catheters, and other ...
|
| 2003-126 |
Pending
|
Research Tools |
Radiolabeled Thymidine Solid-Phase Extraction Purification Method
This solid-phase extraction purification method can purify radiolabeled thymidine quickly and conveniently. ...
|
| 2003-149 |
|
Therapeutics |
Proteomic Design and Chemical Synthesis of Amino Acids with High Blood-Brain Barrier Permeability
The present invention is the protemic design and chemical synthesis of amino acid polymers with improved ...
|
| 2003-149B |
|
Diagnostics |
Proteomic Design and Chemical Synthesis of Magnetic Resonance Contrast Agent with Enhanced In Vitro Binding, High Blood-Brain Barrier Permeability, and In Vivo Targeting to Alzheimer's Disease Amyloid Plaques
The present invention is the protemic design and chemical synthesis of amino acid polymers with improved ...
|
| 2003-150 |
|
Research Tools |
An IEX-1 Null Mutant Mouse
A mouse lacking both copies of the IEX-1 gene was generated. These mice have a mean arterial blood pressure ...
|
| 2003-157 |
None
|
Diagnostics |
Measurement of Superimposed P Wave Duration as a Quantitative Marker of Left Atrial Size
We describe a new method of ECG analysis which has the strongest quantitative correlation in comparison with ...
|
| 2003-185 |
|
Electronic Devices |
Modular Pipeline Fast Fourier Transform
The invention describes a new algorithm and hardware architecture to compute the fast Fourier transform ...
|
| 2003-190 |
Pending
|
Medical Devices |
Biofilm Removal From Surfaces
Vortexing sonication bath fluid prior to sonication significantly enhances the removal of bacterial biofilms ...
|
| 2003-196 |
None
|
Research Tools |
Transgenic Line of Mice Congenitally Devoid of Eosinophils
Transgenic mice were created through DNA microinjection of a construct utilizing mouse EPO derived regulatory ...
|
| 2003-222 |
|
Research Tools |
Transgenic Mice Expressing Mutant Protein Kinase C lota in the Colonic Epithelium
Atypical Protein Kinase-C iota (PKCi) has been implicated as an oncogene in several cancer types. Mayo Clinic ...
|
| 2002-010 |
Pending
|
Diagnostics |
Methods of Human Prostate Cancer Diagnosis - U.S. Patent 5,658,730 issued August 19, 1997
Patent with CTRC Research Foundation...
|
| 2002-017 |
|
Therapeutics |
A Peptide Vaccine to Induce Immunity to Epstein Barr Virus
A promiscuous T cell peptide epitope from the EBNA2 antigen has been identified. T cells induced with this ...
|
| 2002-029 |
|
Diagnostics |
Computer-aided Detection of Liver Tumor Halos in Ultrasound Images
This invention developed a novel computer-aided method for identification of liver tumor halos. The edge of ...
|
| 2002-038 |
|
Medical Devices |
Synthetic Aortic Valve Leaflet With Inlaid Stress-Bearing Fibers and Synthetic Nodulus of Arantzius
A synthetic valve/leaflet for manufacturing cardiac valve prostheses - mechanical characteristics include ...
|
| 2002-039 |
|
Research Tools |
ICOS Mutants
This invention relates to T cell-mediate immune responses, and more particularly to compositions and methods ...
|
| 2002-074 |
|
Medical Devices |
Antibiotic Impregnated Peripherally Inserted Central Catheters (PICC's) with Continuous Central Venous Oximetry
A peripherally inserted central catheter includes three lumens that communicate with its proximal end. A ...
|
| 2002-098 |
None
|
Research Tools |
An Auto-regulated Doxycycline-inducible FIV-based Lentiviral Vector
This invention allows 1) inducible and regulated expression of a gene of interest from an integrated feline ...
|
| 2002-103 |
|
Electronic Devices |
Transmission Matrix De-embedding/Two-Tier Calibration Methods for Vector Network Analyzer (VNA) Measurement
We present a method for performing de-embedding (or equivalently, second-tier calibration) of vector network ...
|
| 2002-111 |
|
Software |
A Method and Apparatus for Disambiguation of Acronyms and Abbreviations
Systems and methods for disambiguating acronyms and abbreviations in written medical text.
...
|
| 2002-115 |
None
|
Research Tools |
2B7: A Chinese Hamster Ovary Cell Line Expressing High Levels of Human Amyloid Beta Protein Precursor
This cell line is a stably transfected Chinese hamster ovary (CHO) cell line. It is transfected with the ...
|
| 2002-116 |
None
|
Research Tools |
H4 wt APP Cells (H4 Cell Line)
H4 cell line stably transfected with an APP695wt clone in the pCDNA3 vector....
|
| 2002-121 |
None
|
Research Tools |
Monoclonal Antibody B4-78
A monoclonal antibody that interacts with the liver and bone isoenzymes of human alkaline phosphatase....
|
| 2002-126 |
|
Diagnostics |
Sulfotransferase (SULT) 2B1 Pharmacogenetics
The activity of the gene product is Sulfate conjugation. Several non-synonymous CSNPs have been discovered ...
|
| 2002-141 |
None
|
Software |
Mayo Image Studio
Mayo Image Studio is an integrated PACS solution conmprising MayoImageX (A Dicon-based toolkit for image ...
|
| 2002-148 |
None
|
Diagnostics |
Rapid Asthma Kit (Rapid EDN Kit) by Immunochromatography
No commercial rapid diagnostic kits for asthma and allergic diseases are currently available. We are ...
|
| 2002-151 |
|
Diagnostics |
Functionally Relevent Genetic Polymorphisms in the Human Sulfotransferase (SULT) 1A3 Gene
SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It ...
|
| 2002-152 |
|
Diagnostics |
Functionally Relevant Polymorphisms in the Human Phenylethanolamine N-Methyltransferase (PNMT) Gene
PNMT is the terminal enzyme in catecholamine biosynthesis and catalyses the synthesis of epinephrine from ...
|
| 2002-167 |
None
|
Medical Devices |
MRI Receiver Coil with Transmit Only Sections Designed to Reduce Artifacts
An RF coil with added coils which transmit only to reduce artifactual signals due to flow or poor magnet ...
|
| 2002-179 |
|
Diagnostics |
Time of Flight X-Ray Imaging
Mayo researchers have developed a method to allow clinical x-ray imaging to reach its full potential. This ...
|
| 2002-180 |
None
|
Therapeutics |
Dominant Negative Inhibitor of Apoptosis Based on HIV Vpr
Apoptosis is a form of cell death that is abnormally regulated in a large variety of disease states. HIV Vpr ...
|
| 2002-187 |
|
Electronic Devices |
Detection of Vagus Nerve Stimulator Activity
This method enables non-invasive and invasive detection of vagus nerve stimulator activity. Vagus nerve ...
|
| 2002-213 |
Pending
|
Electronic Devices |
Dual Electrospray Ionization Source for Mass Spectrometry
The device indexes an electrified, ion spraying, glass nozzle to the inlet port of a mass spectrometer. ...
|
| 2002-225 |
Pending
|
Therapeutics |
Modulation of Toll-like Receptor 4 Signaling, or Other TLRs for Treatment or Prevention of Obesity and Excess Fat
Mayo Clinic researchers have identified the use of biological, pharmacological or saccharide intervention, ...
|
| 2002-226 |
Pending
|
Therapeutics |
Modulation of Toll-like Receptor 4 or Other TLRs for Treatment or Prevention of Bone Loss
Mayo Clinic researchers have identified the use of biological, pharmacological or saccharide intervention, ...
|
| 2002-227 |
|
Diagnostics |
Functionally Relevant Polymorphisms in the Human Arsenic N-Methyltransferase (AMT) Gene
The enzyme utilizes S-adenosylmethionine to methylate aresenite to monomethylarsonate, and can further ...
|
| 2002-244 |
Pending
|
Therapeutics |
Identification of the PKHDL1 Gene. A Receptor with Inducible T Lymphocyte Expression
Mayo Clinic has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in ...
|
| 2001-005 |
|
Electronic Devices |
Micro-Electro-Mechanical (MEMS) Lateral Switch Topology
A Micro-Electro-mechanical System Lateral Switch. The switch includes a complaint spring that supports a ...
|
| 2001-009 |
|
Diagnostics |
Functionally Relevant Genetic Polymorphisms in the Human Sulfotransferase (SULT) 2A1 Gene
SULT2A1 catalyzes the transfer of inorganic sulfate to hydroxysteroids and uses PAPS as the sulfate donor. ...
|
| 2001-023 |
|
Research Tools |
BRI-ABeta Fusion Proteins: A Novel Means for Specific High-Level Expression of ABeta Peptides
A novel expression system has been developed that selectively expresses ABeta40 or ABeta42 in the secretory ...
|
| 2001-039 |
|
Research Tools |
Solid-Phase Synthesis Using Chlorotrityl Resins
Mayo has developed methods for loading amino derivatives onto chlorotrityl resins.
...
|
| 2001-049 |
|
Diagnostics |
Device for Demonstration of Active Forearm Instability with Computerized Tomography
Device reproducibly positions subject's upper extremities in field of CT imaging system; allows variable ...
|
| 2001-050 |
|
Diagnostics |
Device for Measuring Actively Generated Forearm Torque in Different Positions of Forearm Rotation
Device reproducibly positions subject's upper extremities while allowing measurement of actively generated ...
|
| 2001-087 |
|
Medical Devices |
Pedicle Oblique Support Pillar
Pedicle oblique support pillar system; shares loads applied to pedicle implant in spine fracture fixation; ...
|
| 2001-091 |
Pending
|
Therapeutics |
Regulation of Toll-like Receptors by Complex Saccharides
We have discovered that complex saccharides, specifically heparan sulfate glycosaminoglycans, signal cells ...
|
| 2001-099 |
|
Therapeutics |
Improved Bioartificial Liver for Extended Operation
This new bioartificial liver design will be used to increase the number of cells which can be utilized within ...
|
| 2001-113 |
|
Research Tools |
Genetically-Engineered Mouse Line with PAPP-A Gene Deletion
Development of a line of mice homozygous for targeted disruption of the pregnancy-associated plasma protein-A ...
|
| 2001-127 |
Pending
|
Therapeutics |
Treatment for Central Nervous System Disorders
Therapeutic compositions and methods for treating Alzheimer's disease have been developed whereby an ...
|
| 2001-129 |
|
Diagnostics |
Measurement of Shear Modulus
A new method is proposed to measure the shear elasticity and shear viscosity at an optically clear material. ...
|
| 2001-138 |
|
Diagnostics |
Functionally Relevant Genetic Polymorphisms in the Human Estrogen Sulfotransferase (SULT1E1) Gene
SULT1E1 catalyzes reactions with steroid hormones e.g. ß-Estradiol, by transferring a sulfonate group from ...
|
| 2001-139 |
|
Diagnostics |
Funtionally Relevant Genetic Polymorphisms in the Human 3'-Phosphoadenosine 5'-Phosphosulfate Synthetase 1 (PAPSS1) Gene
There are two separate 3'-phosphoadenosine 5'-phosphosulfate synthetase (PAPSS) isoforms in humans (PAPSS1 ...
|
| 2001-148 |
Pending
|
Diagnostics |
Identification of the Autosomal Recessive Polycystic Kidney Disease Gene (ARPKD):
Mayo has identified and characterized the gene PKDH1 that is mutated in the human genetic disease autosomal ...
|
| 2001-152 |
|
Therapeutics |
Procter & Gamble Patent Portfolio - Colonic Delivery Technology
Technology portfolio related to Pharmaceutical Dosage Form for Colonic Delivery, Pharmaceutical Dosage Form ...
|
| 2001-155 |
Pending
|
Therapeutics |
Midodrine for Treatment of Psoriasis
A novel agent and formulation for treatment of psoriasis through a topical approach. Midodrine is a generic ...
|
| 2001-158 |
|
Research Tools |
Display of Polypeptides on the Envelope Glycoproteins of Avian Leukosis Viruses
The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides ...
|
| 2001-162 |
|
Therapeutics |
Potentiation of Immune Response Using Antibodies That Bind Dendritic Cells
An antibody has been discovered that binds mouse dendritic cells and potentiates their ability to induce ...
|
| 2001-168 |
None
|
Medical Devices |
Elbow Arthroscopy Arm Holder
Currently looking for a licensing partner for arm positioner device for elbow surgery-- attaches to surgical ...
|
| 2000-001 |
|
Therapeutics |
A Transcriptionally Active Promoter-Gene System with Intrinsic Immunotherapeutic Benefit
The invention uses a constitutively active form of the Heat Shock Factor-1 (HSF-1) transcription factor to ...
|
| 2000-007 |
|
Research Tools |
Double Subtractive mRNA Fingerprinting (DSF)
Subtraction of mRNAs is first performed by a novel method. The subtracted mRNAs are then subjected to ...
|
| 2000-008 |
|
Research Tools |
Preferential Amplification from Coding Sequences
With specially designed primers, segments from the coding region of mRNAs is amplified by Polymerase Chain ...
|
| 2000-017 |
|
Medical Devices |
Anatomic Incontinence Pessary
Anatomy shaped vaginal pessary with adjustable suburethral pressure mechanism....
|
| 2000-023 |
None
|
Research Tools |
Feline Immunodeficiency Virus (FIV) Transfer Vectors CT23 and CT25a
This new lentiviral transfer vector with a minimal portion of the gag open reading frame and a versatile ...
|
| 2000-025 |
|
Diagnostics |
Targeting of Alzheimer's Amyloid Plaques
A composition and method for detecting parenchymal plaque deposits in the brain of a living mammal. The ...
|
| 2000-028 |
|
Therapeutics |
Administering Mismatch PNAs to Modulate a Biologic Response
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 2000-029 |
|
Therapeutics |
Action of PNAs on DNA
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 2000-031 |
|
Diagnostics |
Genetic Polymorphisms in the Human Sulfotransferase (SULT1C1) Gene
Human SULT1C1 has been shown to metabolically activate planar phenols and the chemical procarcinogen ...
|
| 2000-033 |
|
Medical Devices |
Pre-Deployment Stent Chamber
Toughy "type" holding chamber to clean stent, deliver genes and seed/impregnate stents.
...
|
| 2000-050 |
None
|
Software |
BIRPACS-An Efficient DICOM Image Communication System
BIRPACS is a software system that efficiently implements all the basic features of a Picture Archiving and ...
|
| 2000-064 |
None
|
Research Tools |
HLA-DR3.Abo Transgenic Mice
We developed an HLA-DR3.Abo mouse by introducing the DR3 transgene into a H2Abo mouse, class II negative ...
|
| 2000-065 |
|
Research Tools |
HLA-DQ8/DR3.Abo Transgenic Line
Mouse class II-deficient HLA-DQB1*0302, DQA1*0301 (DQ8) transgenic mice are susceptible to severe ...
|
| 2000-066 |
|
Research Tools |
Transgenic Mice Expressing Human Tau with the P301L Mutation
We have created two lines of transgenic mice expressing human tau with the P301L mutation. Mice expressing ...
|
| 2000-074 |
None
|
Electronic Devices |
Rate Adaptive Algorithm for Termination of Artial Fibrillation with High Frequency Burst Pacing
Current implantable defibrillators attempt to terminate atrial fibrillation painlessly by utilizing 50 Hz ...
|
| 2000-075 |
None
|
Electronic Devices |
A New Treatment for Atrial Fibrillation - A Transesophageal High Frequency Pacing Algorithm
In the past, the transesophageal echo probe has been used exclusively as a diagnostic tool. However, the ...
|
| 2000-080 |
|
Therapeutics |
Treatment of Neutrophil-Associated Pulmonary Diseases with Lidocaine
The treatment of neutrophil-associated pulmonary inflammation including chronic obstructive pulmonary disease ...
|
| 2000-097 |
|
Software |
A Method for Contrast Perfusion Data Recovery from Ultrasound Signals
A mathematical adaptive model of an acoustic broadband spectrum receivd by an ultrasound transducer from ...
|
| 2000-098 |
|
Diagnostics |
Single Ear Fetal Hearing Tester
This devise uses ultrasound to test hearing sensitivity of the fetus at each ear.
...
|
| 2000-100 |
|
Diagnostics |
Genetic Polymorphisms in the Human 3'-phosphoadenosine 5'-phosphosulfate Synthetase 2 (PAPSS2) Gene
PAPSS2 is an enzyme that synthesizes PAPS; the high-energy sulfate donor molecule involved in the sulfate ...
|
| 2000-112 |
|
Diagnostics |
Endothelin Converting Enzymes (ECE) and Amyloid Beta (AB) Degradation
Endothelin converting enzyme (ECE) has been shown to play a fundamental role in â-amyloid metabolic pathways. ...
|
| 2000-131 |
None
|
Software |
Analyze Interface for Brain Atlas
An interactive software interface to a detailed brain atlas developed by Kent Ridge Digital Laboratories in ...
|
| 2000-148 |
Pending
|
Therapeutics |
Improved Peptide Vaccines for Cancer that Stimulate Cytotoxic and Helper T Lymphocytes
Synthetic peptides containing epitopes recognized by both cytotoxic and T helper lymphocytes constitute ...
|
| 2000-155 |
|
Medical Devices |
Segmented Flexible Coated Porous Tantalum Femoral Stem
Prosthesis with varying stem stiffness from proximal to distal ends; minimizes stress shielding; decreases ...
|
| 2000-170 |
None
|
Research Tools |
Central Polypurine Tract (CPPT) and Central Termination Sequence (CTS) of Feline Immunodeficiency Virus and FIV Vectors Containing These Elements
The FIV CPPT and CTS were identified by a combination of molecular techniques and shown to augment FIV vector ...
|
| 1999-020 |
|
Software |
Novel Method for Molecular Dynamics Simulations of Zinc Proteins
A successful computational method was developed to perform molecular dynamics simulations of zinc's ...
|
| 1999-033 |
|
Diagnostics |
Methods for Making Clinical Ultrasound Scanners Quieter
These methods reduce the audible sound produced by ultrasound scanners in patients. Reduction of fetal ...
|
| 1999-036 |
None
|
Software |
AVWPC - A Visualization Workshop for PCs
AVWPC is a comprehensive set of imaging functions which facilitates full exploration and analysis of ...
|
| 1999-056 |
|
Electronic Devices |
Self-Terminating High-Speed Low-Power Logic Transceiver Enabling Compatibility Between CMOS Based Logic Devices of Differing Supply Voltages
A CMOS based digital output buffer circuit and input buffer circuit, with both circuits forming a transceiver ...
|
| 1999-061 |
|
Therapeutics |
Cellular Stent-Based Gene Delivery
This is a cell therapy delivery system which allows efficient and long term vascular delivery....
|
| 1999-064 |
None
|
Research Tools |
Anti-murine Major Basic Protein-1 Polyclonal (rabbit) Antisera
Investigators have developed a rabbit polyclonal antisera reactive against murine major basic protein-1 ...
|
| 1999-065 |
None
|
Research Tools |
Mouse Monoclonal Antibodies Against Murine Eosinophil Peroxidase (mEPO)
Investigators are combining mEPO and together with mEPO deficient gene knock-out animals to create a battery ...
|
| 1999-072 |
None
|
Diagnostics |
Techniques for Internal Standardization and Control of Immunoassays and Gene-Probe Assays
Multiple techniques are developed to provide internal controls and standards for assays using individually ...
|
| 1999-086 |
|
Software |
Quality Control System for Medically Relevant Analytic Performance
Algorithms for a comprehensive QC system are presented.
...
|
| 1999-087 |
None
|
Therapeutics |
Treatment of Eosinophil-Associated Pathologies by Signal Transduction Pathways
Compounds that modulate signal transduction such as lidocaine and other topical anesthetics for the treatment ...
|
| 1998-008 |
None
|
Research Tools |
Collection of Genotyped Vancomycin Resistant Enterococci
Collection of 36 genotyped vancomycin-resistant enterococci including vanA, vanB, vanC, and vanC2-3 ...
|
| 1998-009 |
|
Therapeutics |
Immunotherapy of Plasmaproliferative Disorders Utilizing an Antibody Engineered scFv
Multiple myeloma is a universally fatal plasmaproliferative disorder despite aggressive chemotherapy and ...
|
| 1998-011 |
None
|
Diagnostics |
Assay for ATR Kinase Activity
Integrity of the genome is monitored at multiple cell-cycle check points throughout the cell cycle. ...
|
| 1998-025 |
Pending
|
Research Tools |
Hormone-Related Polyclonal Antibodies
N-Terminal polyclonal affinity purified PTH, polyclonal antibody, PTH-related antibody proinsulin-polyclonal, ...
|
| 1998-026 |
|
Research Tools |
Mutations in the Microtubule Associated Protein tau Cause Neurodegenerative Disease
Mutations in the tau gene have been discovered that are linked to Tau pathologies. Identification of these ...
|
| 1998-036 |
|
Diagnostics |
Human Histamine N-methyltransferase (HNMT) Pharmacogenomics
Histamine N-methyltransferase (HNMT, EC2.1.1.8) catalyzes a major pathway in the metabolism of histamine. ...
|
| 1998-038 |
None
|
Research Tools |
Eosinophil-specific Promoter
Investigators have isolated regulatory sequences from the murine EPO gene that permit eosinophil-lineage ...
|
| 1998-055 |
None
|
Diagnostics |
cDNA and SULT2B1 Sulfotransferase Gene Structure and Genetic Polymorphism
Sulfate conjugation catalyzed by sulfotransferase (SULT) enzymes plays an improtant role in the ...
|
| 1998-060 |
|
Medical Devices |
An Intracoronary Breaking Stent
A stent that fractures at strategic points to relieve arterial stress after placement....
|
| 1998-062 |
|
Medical Devices |
Endocervical and Ectocervical/Vaginal Brush for Pap Smear Collection
Injection-molded devices used to collect the endocervical, ectocervical and vaginal component for use with ...
|
| 1998-066 |
|
Therapeutics |
Probiotic Mix of Bacteria and Yeast
The Mayo Clinic is developing and testing a synbiotic (composition of synergistic probiotic organisms and a ...
|
| 1998-071 |
|
Diagnostics |
SULT1A1 and 1A2 Pharmacogenomics
Substrates for SULT1A1 are; 4-nitrophenol, 17beta-estradiol (E2), diethylstilboestrol (DES), 1-naphol, ...
|
| 1998-076 |
|
Therapeutics |
Use of Botox-A in the Treatment of Cutaneous Wounds
Short term paralysis of underlying musculature to improve cutaneous wound healing in tramatic and ...
|
| 1997-001 |
|
Therapeutics |
Use of Combined Growth Factor and Carrier Protein Therapy to Increase Bone Mass in Humans
With the aging of the population, osteoporosis is emerging as a major public health problem. Drugs used to ...
|
| 1997-035 |
None
|
Research Tools |
ZAP-70-Deficient T-cell Activation Model
This technology is a T-cell line that lacks the protein tyrosine kinase, ZAP-70. ZAP-70 plays a critical ...
|
| 1997-053 |
|
Therapeutics |
Novel Oxime-Based Cholinesterase Reactivators as Antidotes for Organophosphates
An efficient and economical synthesis for novel oxime analogs yields analogs that are up to 100-fold more ...
|
| 1997-069 |
None
|
Research Tools |
Transgenic Mouse Line HLA-DR2
We developed an HLA-DR2 mouse model by introducing a human DRB1*1502(DR2DW12) transgene into CIA susceptible ...
|
| 1997-071 |
None
|
Research Tools |
HLA-DR4 (DRB1*0401) Transgenic Mice
We generated an HLA-DR4ß(NT) transgene construct in which positions 110 and 139 were altered to resemble ...
|
| 1997-072 |
None
|
Research Tools |
Transgenic Mouse Line HLA-DQ6
We generated mice transgenic for HLA-DQ6, an allele associated with a nonsusceptible haplotype. These mice ...
|
| 1997-103 |
|
Medical Devices |
Self-Tapping Expanding Screw in Spinal Surgery
Expanding screw with increased strength of bone-screw interface for spinal internal fixation surgeries....
|
| 1997-105 |
|
Therapeutics |
Use of Peptide Nucleic Acids (PNA's) to Turn off Gene Expression
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 1997-106 |
None
|
Research Tools |
Establishment of Human Myeloma Cell Lines
Mayo researchers have established several human multiple myeloma cell lines, including the ANBL-6 line....
|
| 1997-111 |
|
Diagnostics |
A Fast Screening Assay for Human Coagulation Factor V R506Q
This factor V screening assay can be used to detect heterozygous and homozygous carriers of point mutation ...
|
| 1997-112 |
None
|
Research Tools |
A Preclinical Mouse Model for use in MUC1 Immunotherapy Protocols
An inbred strain of transgenic mice that show tissue-specific expression of the human MUC1 gene. These ...
|
| 1997-123 |
None
|
Research Tools |
Identification of Genes with Diagnostic or Therapeutic Potential in a Population Based Cohort of Patients with Ulcerative Colitis and Crohn's Disease
Creating an electronic database of an entire population of patients with Crohn's disease and ulcerative ...
|
| 1996-076 |
|
Research Tools |
Transgenic Mouse Model for Alzheimer's Disease
Transgenic mouse (Tg2576) carrying the Swedish mutation for Alzheimer?s Disease. This mouse was developed by ...
|
| 1996-085 |
|
Research Tools |
A New Imaging Method with Limited Diffraction Beams
A new imaging method has been developed that allows 3D imaging in a very high frame rate. The method can also ...
|
| 1996-100 |
|
Diagnostics |
Single Beam Vibro-Acoustography System
Radiation force of arbitrary frequency is generated on the object using a single ultrasound beam. This system ...
|
| 1996-106 |
|
Therapeutics |
Bioprosthetic Heart Valve
Mayo has developed improved methods for making heart valves in order to slow heart valve degeneration....
|
| 1996-109 |
None
|
Research Tools |
Monoclonal Antibodies to Basophils
We have developed mouse monoclonal antibodies that bind to basophils, a type of cell that circulates in the ...
|
| 1996-112 |
|
Medical Devices |
Selective Convective Brain Cooling
Enable clinicians to selectively cool the brain, independent of core temperature, as a means of cerebral ...
|
| 1996-121 |
|
Diagnostics |
The Pneumocystis Carinii Cell Division Cycle - 2 (cdc2) Genomic and cDNA Clones
Pneumocystis carinii is an opportunistic fungus that causes an often fatal pneumonia in individuals with ...
|
| 1996-123 |
|
Therapeutics |
The Use of Topical Anesthetics and Glucocorticoids in Combination as a More Effective Treatment for Eosinophil-Related Diseases
Studies have shown that treatment of purified human eosinophils with a combination of lidocaine and ...
|
| 1996-124 |
|
Therapeutics |
Use of Sulfonylureas as a Treatment for Eosinophilic Disease
In vitro treatment of human eosinophils with various sulfonylureas inhibits cytokine-mediated eosinophil ...
|
| 1995-011 |
|
Diagnostics |
Nucleic Acid Probes for Detection and Identification of Several Fungi including Mycobacterium Tuberculosis
The inventions provides nucleic acid probes, primers and methods for detecting fungi that cause disease in ...
|
| 1995-012 |
|
Diagnostics |
Bowtie Limited Diffraction Beams
The newly discovered bowtie limited diffraction beams may achieve low sidelobes and high resolution over a ...
|
| 1995-017 |
|
Therapeutics |
A Peptide Based Vaccine for Prevention and Cure of Rheumatoid Arthritis
Generation of synthetic peptides (15-20 amino acids) that will specifically bind to the major ...
|
| 1995-072 |
|
Research Tools |
TIEG: A Novel TGFß-Estrogen Regulated Early Gene Expressed in Osteoblasts, Breast Tissues and Other Cell and Tissue Types
A marker for detecting breast cancer and implications for pancreatic cancer. The novel TGFß/estrogen ...
|
| 1995-073 |
|
Therapeutics |
Synthesis of Novel Tacrine Analogs as Reversible, Potent and Selective Cholinesterase Inhibitors and Methods for their Use
An efficient and economical synthesis for novel, more lipophilic tacrine analogs has been developed. These ...
|
| 1995-087 |
None
|
Research Tools |
Open Reading Frame Gene Sequence of the Kappa Opioid Receptor from Human Brain
The base sequence coding for the protein of the human kappa opioid receptor, the deduced amino acid sequence ...
|
| 1995-094 |
|
Diagnostics |
Dual Beam Vibro-Acoustography System
In this system, a low frequency radiation force is exerted point-by-point on the object by a confocal ...
|
| 1995-099 |
None
|
Software |
AVW - A Visualization Workshop
AVW is a comprehensive set of imaging functions which facilitates full exploration and analysis of ...
|
| 1995-101 |
None
|
Diagnostics |
PCR Test for Granulocytic Ehrlichia
Mayo Clinic researchers have developed a PCR test for granulocytic ehrlichia....
|
| 1995-102 |
|
Diagnostics |
PCR Detection of WA-1, Ehrlichia spp., and Babesia microti
Detection with the use of broad range primers and the PCR assay for the detection of the WA-1 Agent.
...
|
| 1995-110 |
|
Research Tools |
New Radiolabeled Markers for the Measurement of Colonic Transit
These radiolabeled agents are designed to allow for simple preparation of radioactive markers for measuring ...
|
| 1995-111 |
|
Medical Devices |
Automated Injection Manifold
Automated manifold allows injection of contrast with no manual manipulation of any valves....
|
| 1995-134 |
|
Software |
Learning Algorithm for Left Ventricular Boundary Detection
A statistical learning algorithm about average left ventricular (LV) geometry is described. It allows a ...
|
| 1995-138 |
|
Research Tools |
The Ker14/IL5 Transgenic Mouse is a Model for Eosinophil-mediated Cutaneous Disease.
Transgenic mouse models for allergic skin disorders were developed that express interleukin-5 under the ...
|
| 1995-139 |
|
Research Tools |
NJ1638 Mice ? Hypereosinophilic Transgenic Mice
Transgenic mouse models for eosinophil-mediated tissue inflammation were developed that express interleukin-5 ...
|
| 1995-140 |
|
Research Tools |
The CCIL5 Transgenic Mouse is a Model for Asthma and Eosinophilic Pulmonary Inflammation
Transgenic mouse models for asthma were developed that express interleukin-5 under the control of a lung ...
|
| 1995-155 |
|
Research Tools |
Transfected Human Fetal Osteoblast (FOB) Cell Lines with Estrogen Receptors
HFOBER cells are hFOBs stably transfected with human estrogen receptor; subclones HFOB/ER-3 and HFOB/ER-4 ...
|
| 1995-159 |
|
Diagnostics |
Nonisotopic Measurement of GFR using Conray (iothalamic acid)
A method to determine glomerular filtration rate (GFR) employing capillary electrophoresis to measure the ...
|
| 1994-072 |
|
Diagnostics |
Isolated DNA Encoding Human Liver Estrogen Sulfotransferase
The invention provides an isolated and purified human DNA molecule that encodes human estrogen ...
|
| 1994-090 |
|
Medical Devices |
Long-Stem Femoral Component for Revision THA
Long-stem femoral component coated with multiple in-growth and bioabsorbable materials; allows surgeon ...
|
| 1994-112 |
|
Therapeutics |
Recombinant Human Interleukin-6 as a Treatment for Demyelinating Disease (Multiple Sclerosis)
Researchers utilize a murine model of multiple sclerosis induced by Theiler's virus to test the effect of ...
|
| 1993-001 |
|
Therapeutics |
Vasonatrin Peptide (VNP): Cardiovascular and Renal Actions
Synthetic peptide with blood pressure lowering and natriuretic actions. Brain natriuretic peptide (BNP) has ...
|
| 1993-010 |
|
Research Tools |
Human Fetal Osteoblast Progenitor Cells Lines (hFOB)
Conditionally Immortalized Human Osteoblastic Cell Line: Normal human bone cells were stably transfected ...
|
| 1993-019 |
|
Diagnostics |
MTB Rifampin Resistance Locus - Detection of Rifampin Resistance in Mycobacteria as a Surrogate Test for Multidrug Resistance
The detection of a rifampin resistant locus as a surrogate marker for multiple drug resistant mycobacterium.
...
|
| 1993-030 |
|
Diagnostics |
Human Thiopurine Methyltransferase (TPMT) Gene Discovery
Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs ...
|
| 1993-030B |
|
Research Tools |
Stably-transformed cells expressing human thiopurine methyltransferase
Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs ...
|
| 1993-058 |
None
|
Research Tools |
Human Neurotensin Receptor Polymorphism and Gene Encoding Same
Open reading frame gene sequence of the neurotensin receptors from human brain tissue....
|
| 1993-094 |
|
Therapeutics |
Potential Treatment for cholangiocarcinomas
Somatostatin and its analogues may be useful in inhibiting the growth of cholangiocarcinoma in vivo....
|
| 1993-096 |
|
Diagnostics |
Detection of Isoniazid Resistant Strains of Mycobacterium Tuberculosis
A rapid method to 1) identify Mycobacterium tuberculosis and 2) detect isoniazid resistance in Mycobacterium ...
|
| 1993-104 |
None
|
Software |
Diabetes Electronic Record History System (DEMS)
A visual and graphical software system of recording and retrieving information relevant to patients with ...
|
| 1992-081 |
|
Therapeutics |
Treatment of Bronchial Asthma with Inhaled Lidocaine
A novel treatment for bronchial asthma.This therapy is based on the ability of lidocaine to block the ...
|
| 1989-057 |
|
Medical Devices |
Nondiffracting Transducer for Medical Imaging and Diagnosis
Nondiffracting transducer used to improve resolution of pulse-echo imaging
...
|
| 1988-017 |
|
Diagnostics |
Fundamental Molecular Engineering and Diagnostic Methods
Methods include: * In vitro transcription; ** In vitro protein translation; *** Protein truncation ...
|
| 1988-032 |
|
Therapeutics |
Method For Gene Splicing By Using Overlap Extension (SOE)
A method is provided for joining two DNA molecules by first amplifying them by means of polymerase chain ...
|
| 1988-049 |
None
|
Research Tools |
Immature Human Mast Cell Line HMC-1
HMC-1 is a one-of-a kind human cell line which can serve as a resource for mast cell proteins including ...
|
| 1987-036A |
|
Therapeutics |
Method of Treating Immunopathologic Disorder Mediated by CD8+ T Cells
A method of treating an immunopathologic disorder, which is mediated by CD8+ phenotype T cells. Such ...
|
| 1987-036B |
|
Therapeutics |
Treatment of Neruologic Injury by Inhibiting Perforin
A method for treating neurologic injury in an individual, such as with multiple sclerosis, by administering ...
|
| 1987-046 |
|
Research Tools |
BU-1 Antibody
Monoclonal Antibody to Bromo-deoxy-uridine. Useful in cell proliferation kits...
|
