| Reference # |
Patent
Status |
Description |
| 2009-189 |
None
|
Antibody Panel for Detection of Orthopaedic Implant Infection
We have invented a technique for rapidly removing biofilms from the surface of explanted orthopaedic implants ...
|
| 2009-211 |
Pending
|
USP10 as a Therapeutic Target
In cancer cells with wild-type p53, USP10 acts as a tumor suppressor, and activating USP10 appears to be a ...
|
| 2009-221 |
Pending
|
FKBP5 (FKBP51) can Function as a Biomarker for Prediction of Response to Gencitabine, AraC, Paclitaxel, Dovetaxel, SN38 and Etoposide as well as a Biomarker for Tumorgenesis
We found that FKBP5 and (FKBP51), an immunophilin that functions as a scaffold protein between AKT and AKT ...
|
| 2008-021 |
Pending
|
Quantitative Imaging of Chemical Composition Using Dual-Energy, Dual-Source CT: Three Material Decompostion Using Reconstructed Images
Quantitative imaging of chemical composition may be accomplished using dual energy CT. However, dual energy ...
|
| 2008-022 |
Pending
|
Quantitative Imaging of Chemical Compositions Using Dual-Energy, Dual-Source CT: Two Material Decomposition Using Reconstructed Images
Quantitative imaging of chemical composition in patients may be a very useful diagnostic technique for a ...
|
| 2008-073 |
Pending
|
Methods for the Detection of MicroRNAs as Biomarkers for Neurological Disorders
The invention relates to the detection of microRNA molecules and microRNA genotypic sequences as biomarkers ...
|
| 2008-076 |
Pending
|
CYP2D6 Metabolism as a Predictor of Tamoxifen Resistance in HER-2 Positive Breast Cancer
Tamoxifen is a commonly used agent in the management of breast cancer. Tamoxifen is a prodrug, converted to ...
|
| 2008-140 |
Pending
|
Elderly at Risk (EAR) Index
As the population in the United States and the world ages, it is becoming increasingly important for ...
|
| 2008-141 |
Pending
|
A Technique for Projection Space Reconstruction of Dual Source, Dual Energy Spiral CT Data
Dual energy CT performed using dual source scanner geometry is limited to dual energy algorithms that operate ...
|
| 2008-191 |
Pending
|
Acetaminophen Toxicity Pharmocogenomics
Acetaminophen hepatotoxicity is a major cause of acute liver failure in Western societies. Acetaminophen must ...
|
| 2007-005 |
Pending
|
Human Catechol O-Methyltransferase Gene Polymorphisms and Risk for Breast Cancer
Two single nucleotide polymorphism (SNPs) within the COMT gene have been identified as potential biomarkers ...
|
| 2007-012 |
None
|
Monoclonal Anti-Eosinophil Peroxidase (EPX) Antibody and a Diagnostic Histology Test for Detecting the Presence of Eosinophils and Eosinophil Degranulation in Clinical Biopsies
The past 20 years have witnessed an unprecedented increase in eosinophil-associated diseases such as allergy, ...
|
| 2007-021 |
Pending
|
A Highly-Sensitive Plasma Von Willebrand Factor: Ristocetin Cofactor Activity Assay by Flow Cytometry
The von Willebrand factor ristocetin co-factor activity (VWF:RCo) is routinely used in screening of patients ...
|
| 2007-100 |
Pending
|
Phase Offset and Time Delay Correction on Magnetic Resonance Spectroscopy Data
A mathematical method is described that is used to estimate the inherent phase offsets and timing differences ...
|
| 2007-134 |
None
|
Breast Cancer Risk Prediction Model
A multifeature model, based in our benign breast disease cohort, to predict risk of subsequent breast cancer. ...
|
| 2007-142 |
Pending
|
Device to Measure Thrombin Generation in Blood and Plasma
Measurements of blood clotting in the laboratory are essential in diagnosis and management of bleeding ...
|
| 2007-177 |
None
|
Automated Vortexing Sonicator for Dislodging Bacteria from Biofilms
An interdisiplinary group at Mayo Clinic has demonstrated a procedure for sampling the bacteria resident in ...
|
| 2007-193 |
Pending
|
Non-Linear Blending of Dual-Energy Computed Tomography
The invention combines information from two different energies to create a greatly improved visualization ...
|
| 2007-219 |
Pending
|
A Clinical Test for the Identification of Amyloid Proteins in Fat Aspirate Biopsy Specimens by Mass Spectrometry
The management of systemic amyloidosis relies on the treatment of the underlying etiology and differs ...
|
| 2007-229 |
Pending
|
Quantitation of Lobular Involution for Breast Cancer Risk Prediction
Our group was the first to describe that the process of age-related involution (or regression) of the ...
|
| 2007-236 |
Pending
|
Cytidine Analog Pharmacogenomics
Mayo Clinic researchers have discovered polymorphisms that correlate with sensitivity to radiation therapy ...
|
| 2007-306 |
Pending
|
Microvesicle Phenotype as a Diagnostic
Microvesicles/microparticles are fragments of cellular membranes which are released into the peripheral ...
|
| 2006-067 |
Pending
|
A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q in Human Oligodendrogliomas and Predicts and Better Prognosis of These Patients
Combined deletions of the chromosomes 1p and 19q arms are associated with glioma of oligodendroglial lineage. ...
|
| 2006-104 |
Pending
|
Soluble Prostate Diagnostic/Early Detection Biomarkers
A discriminating panel of genes has been identified that may be used for early detection of prostate cancer. ...
|
| 2006-107 |
Pending
|
Clinical Applications of Serum HtrA1 as Markers for Pre-Eclampsia, Osteoarthritis, and Cardiovascular Diseases
We have generated polyclonal antibodies against HtrA1, and established an ELISA protocol that successfully ...
|
| 2006-130 |
Pending
|
Role of Progranulin in Neurodegenerative Disease
Frontotemporal dementia (FTD) is the second most common cause of dementia in people under 65 years. A large ...
|
| 2006-149 |
Pending
|
Molecular Markers for Biological Response to PPARgamma Agonists
Peroxisomal proliferating activated receptor (PPARgamma) agonists are ligands that bind to PPARgamma, a ...
|
| 2006-161 |
Pending
|
Gene Can Predict Aggressiveness of Prostate Cancer
Mayo Clinic researchers have identified a gene panel that correlates with systemic progression and death ...
|
| 2006-162 |
Pending
|
Proliferation (Cell Cycle) Related Genes Can Predict Aggressiveness of Prostate Cancer
A set of prognostics markers for PCa has been identified using novel bioinformatics algorithms which analyze ...
|
| 2006-179 |
Pending
|
Predictive Biomarkers for Parkinson's Disease
We explored an available whole-genome association dataset to identify single nucleotide polymorphisms within ...
|
| 2006-189 |
Pending
|
Markers That Can Predict Aggressiveness of Prostate Cancer
A set of prognostics markers for PCa has been identified using novel bioinformatics algorithms which analyze ...
|
| 2006-194 |
None
|
Genetic Polymorphisms in the Human Serotonin Transporter (SLC6A4) Gene in Caucasian, African American, Han Chinese, and Mexican American Populations (Revised June 2007)
The SLC6A4 gene (also referred to as HTT, 5HTT, OCD1, SERT, 5-HTT, and hSERT) encodes an integral membrane ...
|
| 2006-202 |
Pending
|
Novel Cytochrome P450 (CYP) 2D6 Gene and CYP2D7 Pseudogene Arrangement and Tests for Detection of These Newly Discovered Gene Arrangements
The CYP2D6 gene makes a protein that metabolizes drugs. This gene is highly variable. It can have different ...
|
| 2006-268 |
Pending
|
Expression of Osteogenic Proteins by Circulating Endothelial Precursor Cells as a Diagnostic Test for Vascular Disease
Aortic valve stenosis (AVS) is one of the most common valvular heart diseases. Recent studies have ...
|
| 2006-271 |
Pending
|
Phase-Locked Loop Operation of Rotating X-Ray Tube CT System to Reduce the Impact of Partial Reconstruction Orientation Artifacts
For CT Systems with rotating x-ray tubes (all systems commercially-manufactured at this time), the best ...
|
| 2006-290 |
Pending
|
B7-H3 as a Marker and Target for Cancer Diagnosis, Prognostication, Tumor Vasculature and Therapy
Expression of B7-H3 on the cell surface of tumor cells and tumor-associated vasculature is greatly increased ...
|
| 2006-297 |
Pending
|
Clinical Applications of Serum HtrA1 for Atherosclerosis, Coronary Artery Disease, and Myocardial Infarction
We have developed assay systems to detect serum HtrA1 levels, protease activity, and HtrA1 polymorphisms in ...
|
| 2006-299 |
Pending
|
Clinical Applications of Serum HtrA1 and Its Activity as Markers for Pre-eclampsia
We have developed assay systems to detect serum HtrA1 levels and its protease activity in clinical samples ...
|
| 2005-017 |
|
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
This invention provides methods and materials related to the measurement of TPMT enzymatic activity in ...
|
| 2005-026 |
|
Self-Contained Semi-Active Cooling Mechanism for Very High Power Density Integrated Circuits and Electronic Modules Using a Reversible Endothermic Chemical Reaction
This invention is a completely self-contained and encapsulated "package" into which a high power integrated ...
|
| 2005-059 |
Pending
|
Genetic Test Predicting Brain Aneurysm Rupture
Mayo Clinic researchers have developed a novel genetic test that predicts the rupture of brain aneurysm. The ...
|
| 2005-060 |
Pending
|
Mayo's Older Americans Normative Studies (MOANS)
Age-specific normative data was acquired for people above age 55 on a series of commonly used cognitive ...
|
| 2005-060 |
Pending
|
Mayo's Older Americans Normative Studies (MOANS)
Age-specific normative data was acquired for people above age 55 on a series of commonly used cognitive ...
|
| 2005-072 |
|
Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired ...
|
| 2005-124 |
|
Functionally Relevant, Common Mutations in the Human Sulfotransferase 1A1 (SULT 1A1) Gene
Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a ...
|
| 2005-156 |
|
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed ...
|
| 2005-174 |
None
|
Major Basic Protein Homolog (MBP2): A Specific Human Eosinophil Marker
Eosinophils are blood leukocytes that are characteristically associated with allergic reactions. For example, ...
|
| 2005-211 |
Pending
|
Discovery of a Novel Spliceoform of the Secretin Receptor
Mayo Clinic researchers identified a novel abnormal spliceoform of the secretin receptor in pancreatic and ...
|
| 2005-235 |
None
|
A Diagnostic Test for Chronic Rhinosinusitis Using Fungus Specific IgG
A diagnostic test for chronic rhinosinusitis using fungus specific IgG. Fungus specific IgG, specifically ...
|
| 2005-305 |
Pending
|
Assessing Outcomes for Breast Cancer Patients Treated with Tamoxifen
In the adjuvant treatment of estrogen receptor (ER) positive breast cancer, hormonal therapy reduces the risk ...
|
| 2005-315 |
Pending
|
Measurement of Circulating DHEA Levels for the Determination of Histological Severity of Non-alcoholic Fatty Liver Disease
The severity of non-alcoholic fatty liver disease (NAFLD) can be determined with a high degree of accuracy ...
|
| 2004-139 |
Pending
|
In vivo Visualization of Alzheimer's Amyloid Plaques without a Contrast Agent
One of the cardinal pathologic features of Alzheimer's disease (AD) is formation of senile or amyloid, ...
|
| 2004-153 |
Pending
|
Detection of Circulating Tumor Cells Carrying the BRAF V599E Mutation
A diagnostic test for highly sensitive detection of circulating tumor cells that contain the B-RAF V599E gene ...
|
| 2004-159 |
None
|
Use of Beta Atrial Natriuretic Peptide as a Screening Biomarker for the Detection of Systolic Left Ventricular Dysfunction and as a Co-Marker with BNP to Detect and Evaluate Heart Failure
The heart releases a peptide called atrial natriuretic peptide (ANP). In heart failure, an abnormal form of ...
|
| 2004-185 |
Pending
|
Identification of Mutations in PARK8, a Locus for Familial Parkinson's Disease
Discovery of the genetic cause of clinical, late-onset (typical) Parkinson's disease in multiple families ...
|
| 2004-199 |
None
|
Using Resonance of Artery for Estimation of Arterial Elastic Modulus
It has long been recognized that a high percentage of all cardiovascular disease is associated with a ...
|
| 2004-225 |
Pending
|
Prognostic and Diagnostic Tests for Clear Cell Renal Carcinoma
Gene Expression profiling was used to identify a set of genes that are associated with the progression of ...
|
| 2004-237 |
|
Detection of Shear Waves Using Pulse Echo Ultrasound with Kalman Filtering
The present invention detects the harmonic motion of vibro-acoustography using pulse echo ultrasound and ...
|
| 2004-244 |
|
Measuring Vitamin D2 and D3 using online extraction and Liquid Chromatography Tandem Mass Spectrometry
Deuterated stable isotope (d3-25-hydroxyvitamin D) is added to a 0.2-mL plasma sample as internal standard. ...
|
| 2004-245 |
Pending
|
Multi-beam Radiation Force Generator for Selective Excitation of Vibrational Modes in Objects
The method developed allows selective excitation of an object using the interference of sonic beams. As an ...
|
| 2004-273 |
|
Human Glutathione S-transferase Omega 2 (GSTO2) Genetic Polymorphisms
GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide ...
|
| 2004-274 |
Pending
|
Human Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1 (HSD3 B1) Genetic Polymorphisms
Substrates include pregnenolone, 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA) and ...
|
| 2004-291 |
|
Identification of a Novel LRRK2 Mutation, 6055G>A (G2019S), Linked to Autosomal Dominant Parkinsonism in Families from Several European Populations
Pathogenic mutations of the Leucine-Rich Repeat Kinase 2 (LRRK2) enzyme are recognized as the most frequent ...
|
| 2003-023 |
None
|
Apparatus and Means to Measure Vessel Stiffness
Ultrasonic radiation pressure is used to induce surface waves in the wall of a vessel. The speed and ...
|
| 2003-149B |
|
Proteomic Design and Chemical Synthesis of Magnetic Resonance Contrast Agent with Enhanced In Vitro Binding, High Blood-Brain Barrier Permeability, and In Vivo Targeting to Alzheimer's Disease Amyloid Plaques
The present invention is the protemic design and chemical synthesis of amino acid polymers with improved ...
|
| 2003-157 |
None
|
Measurement of Superimposed P Wave Duration as a Quantitative Marker of Left Atrial Size
We describe a new method of ECG analysis which has the strongest quantitative correlation in comparison with ...
|
| 2002-010 |
Pending
|
Methods of Human Prostate Cancer Diagnosis - U.S. Patent 5,658,730 issued August 19, 1997
Patent with CTRC Research Foundation...
|
| 2002-029 |
|
Computer-aided Detection of Liver Tumor Halos in Ultrasound Images
This invention developed a novel computer-aided method for identification of liver tumor halos. The edge of ...
|
| 2002-126 |
|
Sulfotransferase (SULT) 2B1 Pharmacogenetics
The activity of the gene product is Sulfate conjugation. Several non-synonymous CSNPs have been discovered ...
|
| 2002-148 |
None
|
Rapid Asthma Kit (Rapid EDN Kit) by Immunochromatography
No commercial rapid diagnostic kits for asthma and allergic diseases are currently available. We are ...
|
| 2002-151 |
|
Functionally Relevent Genetic Polymorphisms in the Human Sulfotransferase (SULT) 1A3 Gene
SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It ...
|
| 2002-152 |
|
Functionally Relevant Polymorphisms in the Human Phenylethanolamine N-Methyltransferase (PNMT) Gene
PNMT is the terminal enzyme in catecholamine biosynthesis and catalyses the synthesis of epinephrine from ...
|
| 2002-179 |
|
Time of Flight X-Ray Imaging
Mayo researchers have developed a method to allow clinical x-ray imaging to reach its full potential. This ...
|
| 2002-227 |
|
Functionally Relevant Polymorphisms in the Human Arsenic N-Methyltransferase (AMT) Gene
The enzyme utilizes S-adenosylmethionine to methylate aresenite to monomethylarsonate, and can further ...
|
| 2001-009 |
|
Functionally Relevant Genetic Polymorphisms in the Human Sulfotransferase (SULT) 2A1 Gene
SULT2A1 catalyzes the transfer of inorganic sulfate to hydroxysteroids and uses PAPS as the sulfate donor. ...
|
| 2001-049 |
|
Device for Demonstration of Active Forearm Instability with Computerized Tomography
Device reproducibly positions subject's upper extremities in field of CT imaging system; allows variable ...
|
| 2001-050 |
|
Device for Measuring Actively Generated Forearm Torque in Different Positions of Forearm Rotation
Device reproducibly positions subject's upper extremities while allowing measurement of actively generated ...
|
| 2001-129 |
|
Measurement of Shear Modulus
A new method is proposed to measure the shear elasticity and shear viscosity at an optically clear material. ...
|
| 2001-138 |
|
Functionally Relevant Genetic Polymorphisms in the Human Estrogen Sulfotransferase (SULT1E1) Gene
SULT1E1 catalyzes reactions with steroid hormones e.g. ß-Estradiol, by transferring a sulfonate group from ...
|
| 2001-139 |
|
Funtionally Relevant Genetic Polymorphisms in the Human 3'-Phosphoadenosine 5'-Phosphosulfate Synthetase 1 (PAPSS1) Gene
There are two separate 3'-phosphoadenosine 5'-phosphosulfate synthetase (PAPSS) isoforms in humans (PAPSS1 ...
|
| 2001-148 |
Pending
|
Identification of the Autosomal Recessive Polycystic Kidney Disease Gene (ARPKD):
Mayo has identified and characterized the gene PKDH1 that is mutated in the human genetic disease autosomal ...
|
| 2000-025 |
|
Targeting of Alzheimer's Amyloid Plaques
A composition and method for detecting parenchymal plaque deposits in the brain of a living mammal. The ...
|
| 2000-031 |
|
Genetic Polymorphisms in the Human Sulfotransferase (SULT1C1) Gene
Human SULT1C1 has been shown to metabolically activate planar phenols and the chemical procarcinogen ...
|
| 2000-098 |
|
Single Ear Fetal Hearing Tester
This devise uses ultrasound to test hearing sensitivity of the fetus at each ear.
...
|
| 2000-100 |
|
Genetic Polymorphisms in the Human 3'-phosphoadenosine 5'-phosphosulfate Synthetase 2 (PAPSS2) Gene
PAPSS2 is an enzyme that synthesizes PAPS; the high-energy sulfate donor molecule involved in the sulfate ...
|
| 2000-112 |
|
Endothelin Converting Enzymes (ECE) and Amyloid Beta (AB) Degradation
Endothelin converting enzyme (ECE) has been shown to play a fundamental role in â-amyloid metabolic pathways. ...
|
| 1999-033 |
|
Methods for Making Clinical Ultrasound Scanners Quieter
These methods reduce the audible sound produced by ultrasound scanners in patients. Reduction of fetal ...
|
| 1999-072 |
None
|
Techniques for Internal Standardization and Control of Immunoassays and Gene-Probe Assays
Multiple techniques are developed to provide internal controls and standards for assays using individually ...
|
| 1998-011 |
None
|
Assay for ATR Kinase Activity
Integrity of the genome is monitored at multiple cell-cycle check points throughout the cell cycle. ...
|
| 1998-036 |
|
Human Histamine N-methyltransferase (HNMT) Pharmacogenomics
Histamine N-methyltransferase (HNMT, EC2.1.1.8) catalyzes a major pathway in the metabolism of histamine. ...
|
| 1998-055 |
None
|
cDNA and SULT2B1 Sulfotransferase Gene Structure and Genetic Polymorphism
Sulfate conjugation catalyzed by sulfotransferase (SULT) enzymes plays an improtant role in the ...
|
| 1998-071 |
|
SULT1A1 and 1A2 Pharmacogenomics
Substrates for SULT1A1 are; 4-nitrophenol, 17beta-estradiol (E2), diethylstilboestrol (DES), 1-naphol, ...
|
| 1997-111 |
|
A Fast Screening Assay for Human Coagulation Factor V R506Q
This factor V screening assay can be used to detect heterozygous and homozygous carriers of point mutation ...
|
| 1996-100 |
|
Single Beam Vibro-Acoustography System
Radiation force of arbitrary frequency is generated on the object using a single ultrasound beam. This system ...
|
| 1996-121 |
|
The Pneumocystis Carinii Cell Division Cycle - 2 (cdc2) Genomic and cDNA Clones
Pneumocystis carinii is an opportunistic fungus that causes an often fatal pneumonia in individuals with ...
|
| 1995-011 |
|
Nucleic Acid Probes for Detection and Identification of Several Fungi including Mycobacterium Tuberculosis
The inventions provides nucleic acid probes, primers and methods for detecting fungi that cause disease in ...
|
| 1995-012 |
|
Bowtie Limited Diffraction Beams
The newly discovered bowtie limited diffraction beams may achieve low sidelobes and high resolution over a ...
|
| 1995-094 |
|
Dual Beam Vibro-Acoustography System
In this system, a low frequency radiation force is exerted point-by-point on the object by a confocal ...
|
| 1995-101 |
None
|
PCR Test for Granulocytic Ehrlichia
Mayo Clinic researchers have developed a PCR test for granulocytic ehrlichia....
|
| 1995-102 |
|
PCR Detection of WA-1, Ehrlichia spp., and Babesia microti
Detection with the use of broad range primers and the PCR assay for the detection of the WA-1 Agent.
...
|
| 1995-159 |
|
Nonisotopic Measurement of GFR using Conray (iothalamic acid)
A method to determine glomerular filtration rate (GFR) employing capillary electrophoresis to measure the ...
|
| 1994-072 |
|
Isolated DNA Encoding Human Liver Estrogen Sulfotransferase
The invention provides an isolated and purified human DNA molecule that encodes human estrogen ...
|
| 1993-019 |
|
MTB Rifampin Resistance Locus - Detection of Rifampin Resistance in Mycobacteria as a Surrogate Test for Multidrug Resistance
The detection of a rifampin resistant locus as a surrogate marker for multiple drug resistant mycobacterium.
...
|
| 1993-030 |
|
Human Thiopurine Methyltransferase (TPMT) Gene Discovery
Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs ...
|
| 1993-096 |
|
Detection of Isoniazid Resistant Strains of Mycobacterium Tuberculosis
A rapid method to 1) identify Mycobacterium tuberculosis and 2) detect isoniazid resistance in Mycobacterium ...
|
| 1988-017 |
|
Fundamental Molecular Engineering and Diagnostic Methods
Methods include: * In vitro transcription; ** In vitro protein translation; *** Protein truncation ...
|
