| Reference # |
Patent
Status |
Description |
| 2007-005 |
Pending
|
Human Catechol O-Methyltransferase Gene Polymorphisms and Risk for Breast Cancer
Two single nucleotide polymorphism (SNPs) within the COMT gene have been identified as potential biomarkers ...
|
| 2007-032 |
Pending
|
Novel Cytochrome P450 (CYP) 2D6 Gene and CYP2D7 Pseudogene Arrangements and Tests for Detection of These Newly Discovered Gene Arrangements
The CYP2D6 gene makes a protein that metabolizes drugs. This gene is highly variable. It can have different ...
|
| 2007-033 |
Pending
|
Determination of the Phase of Duplicated CYP2D6 Alleles
These methods enable determination of the phase of duplicated of CYP2D6 alleles using an allele specific ...
|
| 2007-091 |
Pending
|
Urinary Podocyte Excretion as a Diagnostic Marker for Preeclampsia
Preeclampsia is a pregnancy-specific disease characterized by hypertension and occurrence of protein in the ...
|
| 2007-134 |
None
|
Breast Cancer Risk Prediction Model
A multifeature model, based in our benign breast disease cohort, to predict risk of subsequent breast cancer. ...
|
| 2007-177 |
None
|
Automated Vortexing Sonicator for Dislodging Bacteria from Biofilms
An interdisiplinary group at Mayo Clinic has demonstrated a procedure for sampling the bacteria resident in ...
|
| 2007-219 |
Pending
|
A Clinical Test for the Identification of Amyloid Proteins in Fat Aspirate Biopsy Specimens by Mass Spectrometry
The management of systemic amyloidosis relies on the treatment of the underlying etiology and differs ...
|
| 2007-229 |
Pending
|
Quantitation of Lobular Involution for Breast Cancer Risk Prediction
Our group was the first to describe that the process of age-related involution (or regression) of the ...
|
| 2006-067 |
Pending
|
A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q in Human Oligodendrogliomas and Predicts and Better Prognosis of These Patients
Combined deletions of the chromosomes 1p and 19q arms are associated with glioma of oligodendroglial lineage. ...
|
| 2006-104 |
Pending
|
Soluble Prostate Diagnostic/Early Detection Biomarkers
Mayo Clinic researchers have identified seventy genes encoding proteins with putative diagnostic value for ...
|
| 2006-115 |
Pending
|
Pan Anti-beta Amyloid scFVs, Anti-beta Amyloid scFVs Specific for Abeta-40 and Abeta-42 and Methods for Their Delivery to Treat or Prevent Alzheimer's Disease
Accumulation of Abeta in the brain of patients who suffer from Alzheimer?s disease (AD) triggers a complex ...
|
| 2006-130 |
Pending
|
Role of Progranulin in Neurodegenerative Disease
Frontotemporal dementia (FTD) is the second most common cause of dementia in people under 65 years. A large ...
|
| 2006-149 |
Pending
|
Molecular Markers for Biological Response to PPARgamma Agonists
Peroxisomal proliferating activated receptor (PPARgamma) agonists are ligands that bind to PPARgamma, a ...
|
| 2006-161 |
Pending
|
Gene Can Predict Aggressiveness of Prostate Cancer
A set of prognostics markers for PCa has been identified using novel bioinformatics algorithms which analyze ...
|
| 2006-162 |
Pending
|
Proliferation (Cell Cycle) Related Genes Can Predict Aggressiveness of Prostate Cancer
A set of prognostics markers for PCa has been identified using novel bioinformatics algorithms which analyze ...
|
| 2006-179 |
Pending
|
Predictive Biomarkers for Parkinson's Disease
We explored an available whole-genome association dataset to identify single nucleotide polymorphisms within ...
|
| 2006-189 |
Pending
|
Markers That Can Predict Aggressiveness of Prostate Cancer
A set of prognostics markers for PCa has been identified using novel bioinformatics algorithms which analyze ...
|
| 2006-202 |
Pending
|
Novel Cytochrome P450 (CYP) 2D6 Gene and CYP2D7 Pseudogene Arrangement and Tests for Detection of These Newly Discovered Gene Arrangements
The CYP2D6 gene makes a protein that metabolizes drugs. This gene is highly variable. It can have different ...
|
| 2006-255 |
Pending
|
Cofilin-1
A novel plasma biomarker for human heart failure....
|
| 2006-290 |
Pending
|
B7-H3 as a Marker and Target for Cancer Diagnosis, Prognostication, Tumor Vasculature and Therapy
B7-H3 is expressed by kidney and prostate cancer and in these cancers is predictive of cancer progression and ...
|
| 2005-017 |
Pending
|
Tandem Mass Spectrometry (MS/MS) of Thiopurine Methyltransferase (TPMT) Reaction Products in order to Quantitate TPMT Enzyme Activity
This invention provides methods and materials related to the measurement of TPMT enzymatic activity in ...
|
| 2005-059 |
Pending
|
Genetic Test Predicting Brain Aneurysm Rupture
Mayo Clinic researchers have developed a novel genetic test that predicts the rupture of brain aneurysm. The ...
|
| 2005-072 |
Pending
|
Fluorescent In Situ Hybridization (FISH) Probe Development to Detect Immunoglobulin Light Chains Kapa (IGK) and Lambda (IGL) Translocations
Lymphoma, the cancer to the lymph glands and lymphocytes develop as a consequence of acquired ...
|
| 2005-124 |
Pending
|
Functionally Relevant, Common Mutations in the Human Sulfotransferase 1A1 (SULT 1A1) Gene
Common, functionally relevant mutations in the SULT1A1 have been recently discovered. These mutations have a ...
|
| 2005-156 |
Pending
|
Genetic Polymorphisms in the Human Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 (CYP19A1) gene in Caucasian, African American, Han Chinese and Mexican American Populations
Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed ...
|
| 2005-174 |
None
|
Major Basic Protein Homolog (MBP2): A Specific Human Eosinophil Marker
Eosinophils are blood leukocytes that are characteristically associated with allergic reactions. For example, ...
|
| 2005-178 |
Pending
|
Identification of Naturally Processed and Presented Vaccinia Peptides
We have successfully identified a naturally processed and presented vaccinia peptide from a class 1 HLA ...
|
| 2005-211 |
Pending
|
Discovery of a Novel Spliceoform of the Secretin Receptor
Mayo Clinic researchers identified a novel abnormal spliceoform of the secretin receptor in pancreatic and ...
|
| 2005-305 |
Pending
|
Assessing Outcomes for Breast Cancer Patients Treated with Tamoxifen
In the adjuvant treatment of estrogen receptor (ER) positive breast cancer, hormonal therapy reduces the risk ...
|
| 2005-315 |
Pending
|
Measurement of Circulating DHEA Levels for the Determination of Histological Severity of Non-alcoholic Fatty Liver Disease
The severity of non-alcoholic fatty liver disease (NAFLD) can be determined with a high degree of accuracy ...
|
| 2004-139 |
Pending
|
In vivo Visualization of Alzheimer's Amyloid Plaques without a Contrast Agent
One of the cardinal pathologic features of Alzheimer's disease (AD) is formation of senile or amyloid, ...
|
| 2004-153 |
Pending
|
Detection of Circulating Tumor Cells Carrying the BRAF V599E Mutation
A proportion of human cancers, regardless of type, contain a somatic mutation in the BRAF gene, which changes ...
|
| 2004-159 |
Pending
|
Use of Beta Atrial Natriuretic Peptide as a Screening Biomarker for the Detection of Systolic Left Ventricular Dysfunction and as a Co-Marker with BNP to Detect and Evaluate Heart Failure
The heart releases a peptide called atrial natriuretic peptide (ANP). In heart failure, an abnormal form of ...
|
| 2004-162 |
None
|
GLTSCR1 Gene Analysis for Prostate Cancer
Identification of GLTSCR1 gene mutations to predict susceptibility to prostate cancer and to preduct prostate ...
|
| 2004-176 |
Pending
|
Plasma ABeta42/ABeta40 Ratio is a Good Predictor of Alzheimer's Disease
Patients with Alzheimers Disease have large numbers of senile plaques in their brains. A relatively rare ...
|
| 2004-185 |
Pending
|
Identification of Mutations in PARK8, a Locus for Familial Parkinson's Disease
Discovery of the genetic cause of clinical, late-onset (typical) Parkinson's disease in multiple families ...
|
| 2004-199 |
None
|
Using Resonance of Artery for Estimation of Arterial Elastic Modulus
It has long been recognized that a high percentage of all cardiovascular disease is associated with a ...
|
| 2004-225 |
Pending
|
Prognostic and Diagnostic Tests for Clear Cell Renal Carcinoma
Gene Expression profiling was used to identify a set of genes that are associated with the progression of ...
|
| 2004-244 |
Pending
|
Measuring Vitamin D2 and D3 using online extraction and Liquid Chromatography Tandem Mass Spectrometry
Deuterated stable isotope (d3-25-hydroxyvitamin D) is added to a 0.2-mL plasma sample as internal standard. ...
|
| 2004-273 |
|
Human Glutathione S-transferase Omega 2 (GSTO2) Genetic Polymorphisms
GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide ...
|
| 2004-274 |
None
|
Human Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1 (HSD3 B1) Genetic Polymorphisms
Substrates include pregnenolone, 17-hydroxypregnenolone (17-OH-Preg), dehydroepiandrosterone (DHEA) and ...
|
| 2003-008 |
Pending
|
-258 Parkin Promoter SNP
A -258 T/G polymorphism in the parkin gene promoter that is genetically associated with late-onset (typical) ...
|
| 2003-088 |
Pending
|
Molecular Markers for Prostate Cancer
Molecular markers identified by DNA microarrays useful for diagnosis and prognosis of prostate cancer.
...
|
| 2003-134 |
Pending
|
Polymorphisms in GLTSCR1 Are Associated with Cancer Development
Deletions of chromosome regions in 1p and 19q have been associated with gliomas - especially ...
|
| 2003-149 |
|
Proteomic Design and Chemical Synthesis of Amino Acids with High Blood-Brain Barrier Permeability
The present invention is the protemic design and chemical synthesis of amino acid polymers with improved ...
|
| 2003-157 |
None
|
Measurement of Superimposed P Wave Duration as a Quantitative Marker of Left Atrial Size
We describe a new method of ECG analysis which has the strongest quantitative correlation in comparison with ...
|
| 2003-223 |
None
|
Genetic Variation in the CD25 Molecule Predisposes to Type 1 Diabetes
Discovery of single nucleotide polymorphisms in the CD25 molecule which increase susceptibility to type 1 ...
|
| 2002-029 |
|
Computer-aided Detection of Liver Tumor Halos in Ultrasound Images
This invention developed a novel computer-aided method for identification of liver tumor halos. The edge of ...
|
| 2002-066 |
Pending
|
Use of FISH Probes to Detect the t(4;14)(p16.3;q32) and t(14;16)(q32;q23) in Myeloma
The invention provides methods and materials for determining a prognosis for myeloma and myeloma-disposed ...
|
| 2002-074 |
|
Antibiotic Impregnated Peripherally Inserted Central Catheters (PICC's) with Continuous Central Venous Oximetry
A peripherally inserted central catheter includes three lumens that communicate with its proximal end. A ...
|
| 2002-126 |
|
Sulfotransferase (SULT) 2B1 Pharmacogenetics
The activity of the gene product is Sulfate conjugation. Several non-synonymous CSNPs have been discovered ...
|
| 2002-127 |
Pending
|
Measurement of Lymphocyte Receptor Diversity Using a Gene Chip
Immune competence is thought to be related to lymphocyte receptor diversity. There is currently no reliable ...
|
| 2002-148 |
None
|
Rapid Asthma Kit (Rapid EDN Kit) by Immunochromatography
No commercial rapid diagnostic kits for asthma and allergic diseases are currently available. We are ...
|
| 2002-151 |
Pending
|
Functionally Relevent Genetic Polymorphisms in the Human Sulfotransferase (SULT) 1A3 Gene
SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It ...
|
| 2002-152 |
|
Functionally Relevant Polymorphisms in the Human Phenylethanolamine N-Methyltransferase (PNMT) Gene
PNMT is the terminal enzyme in catecholamine biosynthesis and catalyses the synthesis of epinephrine from ...
|
| 2002-227 |
|
Functionally Relevant Polymorphisms in the Human Arsenic N-Methyltransferase (AMT) Gene
The enzyme utilizes S-adenosylmethionine to methylate aresenite to monomethylarsonate, and can further ...
|
| 2001-009 |
|
Functionally Relevant Genetic Polymorphisms in the Human Sulfotransferase (SULT) 2A1 Gene
SULT2A1 catalyzes the transfer of inorganic sulfate to hydroxysteroids and uses PAPS as the sulfate donor. ...
|
| 2001-138 |
|
Functionally Relevant Genetic Polymorphisms in the Human Estrogen Sulfotransferase (SULT1E1) Gene
SULT1E1 catalyzes reactions with steroid hormones e.g. ß-Estradiol, by transferring a sulfonate group from ...
|
| 2001-139 |
|
Funtionally Relevant Genetic Polymorphisms in the Human 3'-Phosphoadenosine 5'-Phosphosulfate Synthetase 1 (PAPSS1) Gene
There are two separate 3'-phosphoadenosine 5'-phosphosulfate synthetase (PAPSS) isoforms in humans (PAPSS1 ...
|
| 2001-148 |
Pending
|
Identification of the Autosomal Recessive Polycystic Kidney Disease Gene (ARPKD):
Mayo has identified and characterized the gene PKDH1 that is mutated in the human genetic disease autosomal ...
|
| 2000-025 |
|
Targeting of Alzheimer's Amyloid Plaques
A composition and method for detecting parenchymal plaque deposits in the brain of a living mammal. The ...
|
| 2000-026 |
|
Supracolonic Aerodigestive Neoplasm Detection
This invention relates to methods and materials involved in the detection of supracolonic aerodigestive ...
|
| 2000-031 |
|
Genetic Polymorphisms in the Human Sulfotransferase (SULT1C1) Gene
Human SULT1C1 has been shown to metabolically activate planar phenols and the chemical procarcinogen ...
|
| 2000-058 |
Pending
|
CRMP-5 and CRMP-5 Antibodies as Markers for Small-Cell Lung Carcinoma, Neuroblastomas and Thymoma, and for Immunotherapy
We have identified in blood of patients a novel antibody that binds to electrically excitable brain cells and ...
|
| 2000-098 |
|
Single Ear Fetal Hearing Tester
This devise uses ultrasound to test hearing sensitivity of the fetus at each ear.
...
|
| 2000-112 |
|
Endothelin Converting Enzymes (ECE) and Amyloid Beta (AB) Degradation
Endothelin converting enzyme (ECE) has been shown to play a fundamental role in â-amyloid metabolic pathways. ...
|
| 1998-011 |
None
|
Assay for ATR Kinase Activity
Integrity of the genome is monitored at multiple cell-cycle check points throughout the cell cycle. ...
|
| 1998-026 |
|
Mutations in the Microtubule Associated Protein tau Cause Neurodegenerative Disease
Mutations in the tau gene have been discovered that are linked to Tau pathologies. Identification of these ...
|
| 1998-036 |
|
Human Histamine N-methyltransferase (HNMT) Pharmacogenomics
Histamine N-methyltransferase (HNMT, EC2.1.1.8) catalyzes a major pathway in the metabolism of histamine. ...
|
| 1998-055 |
None
|
cDNA and SULT2B1 Sulfotransferase Gene Structure and Genetic Polymorphism
Sulfate conjugation catalyzed by sulfotransferase (SULT) enzymes plays an improtant role in the ...
|
| 1997-123 |
None
|
Identification of Genes with Diagnostic or Therapeutic Potential in a Population Based Cohort of Patients with Ulcerative Colitis and Crohn's Disease
Creating an electronic database of an entire population of patients with Crohn's disease and ulcerative ...
|
| 1996-085 |
|
A New Imaging Method with Limited Diffraction Beams
A new imaging method has been developed that allows 3D imaging in a very high frame rate. The method can also ...
|
| 1995-011 |
|
Nucleic Acid Probes for Detection and Identification of Several Fungi including Mycobacterium Tuberculosis
The inventions provides nucleic acid probes, primers and methods for detecting fungi that cause disease in ...
|
| 1995-072 |
|
TIEG: A Novel TGFß-Estrogen Regulated Early Gene Expressed in Osteoblasts, Breast Tissues and Other Cell and Tissue Types
A marker for detecting breast cancer and implications for pancreatic cancer. The novel TGFß/estrogen ...
|
| 1995-094 |
|
Dual Beam Vibro-Acoustography System
In this system, a low frequency radiation force is exerted point-by-point on the object by a confocal ...
|
| 1995-101 |
None
|
PCR Test for Granulocytic Ehrlichia
Mayo Clinic researchers have developed a PCR test for granulocytic ehrlichia....
|
| 1995-102 |
|
PCR Detection of WA-1, Ehrlichia spp., and Babesia microti
Detection with the use of broad range primers and the PCR assay for the detection of the WA-1 Agent.
...
|
| 1995-110 |
|
New Radiolabeled Markers for the Measurement of Colonic Transit
These radiolabeled agents are designed to allow for simple preparation of radioactive markers for measuring ...
|
| 1995-159 |
|
Nonisotopic Measurement of GFR using Conray (iothalamic acid)
A method to determine glomerular filtration rate (GFR) employing capillary electrophoresis to measure the ...
|
| 1993-019 |
|
MTB Rifampin Resistance Locus - Detection of Rifampin Resistance in Mycobacteria as a Surrogate Test for Multidrug Resistance
The detection of a rifampin resistant locus as a surrogate marker for multiple drug resistant mycobacterium.
...
|
| 1993-030 |
|
Human Thiopurine Methyltransferase (TPMT) Gene Discovery
Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs ...
|
| 1993-096 |
|
Detection of Isoniazid Resistant Strains of Mycobacterium Tuberculosis
A rapid method to 1) identify Mycobacterium tuberculosis and 2) detect isoniazid resistance in Mycobacterium ...
|
| 1988-017 |
|
Fundamental Molecular Engineering and Diagnostic Methods
Methods include: * In vitro transcription; ** In vitro protein translation; *** Protein truncation ...
|
