Human Thiopurine Methyltransferase (TPMT) Gene Discovery

Reference #:

1993-030

Inventors/Contributors

Richard M. Weinshilboum, M.D., Ronald Honchel, Ph.D., Ibrahim A. Aksoy, M.D., Ph.D., Carol L. Szumlanski, Thomas C. Wood, Diane M. Otterness, Eric D. Wieben, Ph.D.

Description

Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine, 6-thioguanine and azathioprine. Patent claims to the DNA coding sequence, amino acid sequence and cell lines and mammals in which TPMT is integrated.

Patent Status

	U.S. Patent Number 5,470,737 Issued November 28, 1995