Detection of Isoniazid Resistant Strains of Mycobacterium Tuberculosis

Reference #:

1993-096

Inventors/Contributors

Franklin R. Cockerill III, M.D., Bruce C. Kline, Ph.D., James R. Uhl, Zelalem Temesgen, M.D.

Description

A rapid method to 1) identify Mycobacterium tuberculosis and 2) detect isoniazid resistance in Mycobacterium tuberculosis. In Mycobacterium tuberculosis, a point of mutation in the catalase gene is associated with isoniazid resistance. Isoniazid is a first line drug used to treat tuberculosis, and many strains of Mycobacterium tuberculosis have developed resistance to this drug. This method permits 1) identification of Mycobacterium tuberculosis and 2) detection of isoniazid resistance in as little as 1-2 hours, whereas other current methods to identify Mycobacterium tuberculosis and detect isoniazid resistance take several days, up to weeks.

Patent Status

	U.S. Patent Number 5,658,733 Issued August 19, 1997 U.S. Patent Number 5,688,639 Issued November 18, 1997 U.S. Patent Number 5,922,575 Issued July 13, 1999 Europe Patent Number 0979310 Issued March 13, 2002