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Reference #:
2000-058
Inventors/Contributors
Vanda A. Lennon, M.D., Ph.D., Guy E. Griesmann, Thomas J. Kryzer, Zhiya Yu, Ph.D.
Description
We have identified in blood of patients a novel antibody that binds to electrically excitable brain cells and to lung cancer cells. This antibody serves as a marker of neurological autoimmunity related to lung cancer or a tumor of the thymus gland. We have identified and named CRMP-5 a previously unknown protein as the target of this novel antibody. We have cloned the gene encoding CRMP-5 and made anti-CRMP-5 antibodies by immunizing rats with a product of that gene. There are several potential clinical applications that include detection, imaging and treatment of specific types of cancer.
Patent Status
Pending |
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Contact
Leif R. Nelson, Licensing Manager
nelson.leif@mayo.edu
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Mayo Foundation for Medical Education and Research
Office of Technology Commercialization
Centerplace 4
200 First Street SW
Rochester, MN 55905
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Phone: (507) 266-0820
Fax: (507) 284-5410
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