Endothelin Converting Enzymes (ECE) and Amyloid Beta (AB) Degradation

Reference #:

MMV-00-112

Inventors/Contributors

Christopher B. Eckman, Ph.D., Elizabeth A. Eckman, Ph.D.

Description

Endothelin converting enzyme (ECE) has been shown to play a fundamental role in â-amyloid metabolic pathways. A published study (Journal of Biological Chemistry: 276(27):24540-8, 2001) reported that both ECE-1a and ECE-1b activation reduced the intracellular generation of Aâ40 and A â42, and that ECE-1a may also be able to degrade preexisting protein. The development of strategies able to stimulate or over-express ECE could offer a novel therapy of Alzheimer’s Disease.

Patent Status

	U.S. Patent Number 6,699,681 Issued March 02, 2004