Functionally Relevent Genetic Polymorphisms in the Human Sulfotransferase (SULT) 1A3 Gene

Reference #:

2002-151

Inventors/Contributors

Richard M. Weinshilboum, M.D., Oktay Rifki, Michelle A. Theobald, Bianca A. Thomae, Eric D. Wieben, Ph.D.

Description

SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It is expressed in liver, brain, jejunum, kidney and platelets. It may be associated with schizophrenia, affective disorders, renal disease and chemical carcinogenesis. One particular polymorphism, resulting in an amino acid change, was found to be present in 4% of the African American population tested and reduced the enzyme activity by over 70%.

Patent Status

	U.S. Patent Number 7,425,624 Issued September 16, 2008 U.S. Patent Number 7,745,185 Issued June 29, 2010