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Reference #:
2002-151
Inventors/Contributors
Richard M. Weinshilboum, M.D., Oktay Rifki, Michelle A. Theobald, Bianca A. Thomae, Eric D. Wieben, Ph.D.
Description
SULT1A3 is involved in the sulfation of Dopamine,other catechol monoamines, serotonin, and Troglitazone. It is expressed in liver, brain, jejunum, kidney and platelets. It may be associated with schizophrenia, affective disorders, renal disease and chemical carcinogenesis. One particular polymorphism, resulting in an amino acid change, was found to be present in 4% of the African American population tested and reduced the enzyme activity by over 70%.
Patent Status
Pending |
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