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Reference #:
2003-134
Inventors/Contributors
Robert B. Jenkins, M.D., Ph.D., Ping Yang, M.D.
Description
Deletions of chromosome regions in 1p and 19q have been associated with gliomas - especially oligodendrogliomas. Oligodendrogliomas with these alterations have been observed to have a better survival and a better response to chemo- and/or radiation therapy. Recent evidence suggests that, in addition to acquired alterations, germline polymorphisms mapped tot he 19q-arm are associated with cancer development (e.g. basal cell carcinoma, breast cancer, adenocarcinoma of the lung, and glioma) and with cancer aggressiveness (e.g. prostate cancer). We hypothesize that there is a gene (or genes) on 19q which increase the risk of glioma development and progression, expeically that of oligodendroglioma.
Patent Status
Pending |
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Contact
Susan L. Stoddard, Ph.D., Licensing Manager
sstoddard@mayo.edu
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