Human Glutathione S-transferase Omega 2 (GSTO2) Genetic Polymorphisms

Reference #:

2004-273

Inventors/Contributors

Richard M. Weinshilboum, M.D., Oreste Ezequiel Salavaggione, M.D., Baidehi (Luna) Mukherjee, Linda L. Pelleymounter, Eric D. Wieben, Ph.D.

Description

GST02 is a phase II enzyme that utilize glutathione in reactions contributing to the transformation of a wide range of exogenous and endogenous compounds, including carcinogens, therapeutic drugs, and products of oxidative stress. Known substrates are glutathione (GSH) and dehydroascorbate (DHA. It is expressed in liver, kidney and skeletal muscle and at high levels in the testes and low levels in the heart, lung, cervix, ovary and prostate. Three novel non-synonymous cSNPs have been identified and their functional relevancy is being determined. Novel polymorphisms and common haplotypes for Caucasian American, African American, Han Chinese and Mexican American populations have been identified.

Patent Status

	U.S. Patent Number 7,390,894 Issued June 24, 2008