|
Reference #:
2005-156
Inventors/Contributors
Richard M. Weinshilboum M.D., Eric D. Wieben Ph.D., Oreste Ezequiel Salavaggione M.D., Linda L. Pelleymounter, Araba A. Adjei Ph.D., Liewei Wang M.D., Ph.D., Bruce W. Eckloff, Daniel J. Schaid Ph.D., Alex A. Adjei M.D., Ph.D., Josefa T. Coronel, Cynthia X. Ma M.D., Ph.D.
Description
Some of the known substrates of CYP19A1 (aromatase) include testosterone and androstenedione. It is expressed in the ovaries, testes, placenta, fetal liver, adipose tissue, chondrocytes, osteoblasts, vasculature smooth muscle, and brain. Increased or decreased enzyme activity is associated with several diseases including breast and endometrial cancer. Several novel polymorphisms have been identified, some of which result in amino acid changes that significantly affect CYP19A1 activity.
Patent Status
Pending |
|
Contact
Leif R. Nelson, Licensing Manager
nelson.leif@mayo.edu
|
|
Mayo Foundation for Medical Education and Research
Office of Technology Commercialization
Centerplace 4
200 First Street SW
Rochester, MN 55905
|
Phone: (507) 266-0820
Fax: (507) 284-5410
|
|
|
