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Reference #:
2006-149
Inventors/Contributors
John A. Copland III Ph.D., Robert C. Smallridge M.D.
Description
Peroxisomal proliferating activated receptor (PPARgamma) agonists are ligands that bind to PPARgamma, a transcriptional factor that regulates gene expression. Some of these genes and/or protein products can be used as molecular markers to biological response to drug (PPARgamma agonist) treatment. Three biolgoical markers of response to a PPARg agonist, RhoB, p21 and cyclin E, could be measured by IHC in tissues following treatment with a PPARg agonist. These markers would be predictors of response to therapy for PPARgamma agonists as antitumor agents.
Patent Status
Pending |
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Contact
Susan L. Stoddard, Ph.D., Licensing Manager
sstoddard@mayo.edu
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Mayo Foundation for Medical Education and Research
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