Predictive Biomarkers for Parkinson's Disease

Reference #:

2006-179

Inventors/Contributors

Demetrius (Jim) M. Maraganore M.D., Timothy G. Lesnick

Description

We explored an available whole-genome association dataset to identify single nucleotide polymorphisms within brain-expressed, axon guidance pathway genes that predicted Parkinson’s disease outcomes. We identified models of SNPs that strongly predicted susceptibility (P=4.64 x 10-38), survival free of Parkinson’s disease (P=5.43 x 10-48), and age at onset (P=1.68x10-51). Polymorphism in the axon guidance pathway accounted for nearly 70% of the age at onset variance of Parkinson’s disease, and person with high versus low model scores differed in survival free of Parkinson’s disease by more than 20 years.

Patent Status

Pending