Cytidine Analog Pharmacogenomics

Reference #:

2007-236

Inventors/Contributors

Matthew M. Ames, Ph.D., Liewei Wang, M.D.m, Ph.D., Krishna R. Kalari, Ph.D., Brooke L. Fridley, Ph.D., Daniel J. Schaid, Ph.D., Liang Li, M.D., Ph.D.

Description

Mayo Clinic researchers have discovered polymorphisms that correlate with sensitivity to radiation therapy using a panel of human cell lines from various ethnic groups. These polymorphisms impact the expression of genes in DNA damage repair and cell cycle pathways. Application Stratification of patients that are likely to respond to radiation therapy. Stage of Development Functional validation of identified polymorphisms has been performed in tumor cell lines.

Patent Status

Pending