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Mayo Clinic Technology
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Research Tools

button  = Issued Patent
Reference # Patent
Status
Description
2009-017 Pending Method for Synthesis of Very Long Chain Fatty Acids
Very long chain polyunsaturated fatty acids (VLPUFAs) are present in the human retina and play an important ...
2009-125 None Homozygous Constitutive Mouse Model for Wild-Type TDP-43
This invention includes the development of a homozygous transgenic mouse model expressing wild-type human ...
2009-126 None Inducible Mouse Models for TDP-43
This invention includes the developement of inducible transgenic mice expressing human TDP-43 cDNA encoding ...
2009-132 None Anti-MDC1 Monoclonal Antibody
A monoclonal antibody to MDC1, a key mediator of DNA damage response. ...
2009-161 Pending Tools to Improve Multidisciplinary Management of Anemia for End Stage Renal Disease (ESRD) Patients
This expert system optimizes the delivery of erythropoiesis stimulating agents (ESAs) to treat anemia in ...
2009-294 Pending Cytokine Response Profiling in Rheumatoid Arthritis
Current practice in the management of Rheumatoid Arthritis (RA) involves assessing the progression or ...
2009-296 Pending A Mouse Model of Recessive Polycystic Kidney Disease
Mouse model of recessive polycystic Kidney Disease (ARPKD)...
2009-362 Pending Immunodetection of Covalent Topoisomerase I-DNA Complexes
A number of approved and investigational anticancer drugs target the enzyme topoisomerase I (topo I). ...
2008-016 None Anti-SINA/SIAH Monoclonal Antibodies & Related Know-How
Four mouse anti-SINA/SIAH monoclonal antibodies are available for licensing. Details are as follows. Two ...
2008-035 None 53BPI-Deficient Mice
Mice lacking 53BPI were developed at Mayo to study DNA damage responses and tumor suppression. See Ward et ...
2008-084 None Talley Bowel Disease Questionaire (BDQ)
Validated bowel disease questionaire...
2008-098 None GFP-Centrin2 Expression Vector
A long-standing puzzle in cell biology is the question of how cells generate one and only one new centrosome ...
2008-103 None Monoclonal Antibody Recognizing Abeta 1-38 (MM43-14.1.1)
Monoclonal antibodies were raised to human Abeta 1-38. The peptide used to immunize was Abeta 35-40. This ...
2008-104 None Monoclonal Antibody Recognizing Rodent Abeta 1-16
Monoclonal antibodies were raised to rodent Abeta 1-16. The peptide used to immuize was rodent Abeta 1-16. ...
2008-114 None Caveolin-1 Antibodies
Purified antibodies from rabbit serum that recognize, specifically, the caveolin-1 protein. This specific set ...
2008-115 None Eps15 Mid/C-Terminal Antibodies
Purified antibodies from rabbit serum that specifically recognize the Eps15 protein at two different and ...
2008-120 None Monoclonal Antibody Recognizing Abeta 1-40 (MM32-13.1.1)
Monoclonal antibodies were raised to human Abeta 1-40. The peptide used to immunize was Abeta 35-40. This ...
2008-121 None Monoclonal Antibody Recognizing Abeta 1-16 (MM27-33.1.1)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This ...
2008-122 None Monoclonal Antibody Recognizing Abeta 1-42 (MM26-4.1.3)
Monoclonal antibodies were raised to human Abeta1-42. The peptide used to immunize was Abeta 35-42. ...
2008-123 None Monoclonal Antibody Recognizing Abeta 1-16 (Ab-9)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Abeta 1-16. This ...
2008-124 None Monoclonal Antibody Recognizing Abeta 1-16 (Fibrillar Ab1-42; AB42-5.)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was fibrillar Abeta 1-42. ...
2008-125 None Monoclonal Antibody Recognizing Abeta 1-42 (MM26-2.1.3)
Monoclonal antibodies were raised to human Abeta 1-42. The peptide used to immunize was Abeta 35-42. This ...
2008-126 None Monoclonal Antibody Recognizing Abeta 1-42 (MM40-21.3.1)
Monoclonal antibodies were raised to human Abeta1-42. The peptide used to immunize was Abeta 35-42. This ...
2008-139 None Mouse Monoclonal Antibody Recognizing Abeta1-16, Ab9 Isotype IgAk, Ab9-A, Clone Ab9 15E7.17.10
Mouse monoclonal Ab9-A, isotype A of the original Ab9 mouse monoclonal made to human amyloid beta 1-16, was ...
2008-163 None Inducible Tau Mice Expressing Human 4RON Tau With the P301L Mutation (termed iP301L)
These mice conditionally express the human tau cDNA (4RON isoform) containing the FTDP-17 mutation (P301L) in ...
2008-181 Pending Targeting Adenovirus Using Factor X Fusion Proteins
Blood factors including factor X (fX) bind the hypervariable regions of Ad hexon protein and retarget the ...
2008-195 Pending Generation of iPS Cells for Preclinical and Clinical Studies
Retroviral or lentiviral vector-mediated stable introduction of some stem cell-associated genes can reprogram ...
2008-233 None Polyclonal Antibody Against Human Frataxin Protein
This is a polyclonal antibody raised in a rabbit against the mature form of human frataxin (amino acid ...
2008-261 None LRRK2 G2019S Knock-In Mice
Mice in which the endogenous murine leucine-rich repeat kinase 2 gene (LRRK2; NCBI accession NM_025730 and ...
2008-277 None Human Anaplastic Thyroid Carcinoma Cell Lines
Anaplastic thyroid carcinoma (ATC) is one of the deadliest cancers with lethality of >99% and survival ...
2008-346 None Monoclonal Antibody Recognizing Abeta 1-16 (AB42-2)
Monoclonal antibodies were raised to human Abeta 1-16. The peptide used to immunize was Fibrillar Abeta ...
2007-016 None Transgenic Mouse Expressing P1 Artificial Chromosome (PAC) Containing the Entire Human Alpha-Synuclein (SNCA) Gene
Tansgenic mouse that over-expresses the human alpha-synuclein gene, under the control of its endogenous human ...
2007-027 None LRRK2 BAC Transgenic Mice: A Model of Parkinsonism
Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2)....
2007-032 Pending Novel Cytochrome P450 (CYP) 2D6 Gene and CYP2D7 Pseudogene Arrangements and Tests for Detection of These Newly Discovered Gene Arrangements
The CYP2D6 gene makes a protein that metabolizes drugs. This gene is highly variable. It can have different ...
2007-033 Pending Determination of the Phase of Duplicated CYP2D6 Alleles
These methods enable determination of the phase of duplicated of CYP2D6 alleles using an allele specific ...
2007-050 None Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from AL Amyloidsis
The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell ...
2007-064 Pending Human Pharmacogenomic Variation Cell Line Panel
Mayo Clinic researchers have identified a small set of genes for which expression correlates strongly with ...
2007-103 Pending In Vitro and In Vivo Models of TDP-43 and TDP-43 as Biomarker for Neurodegenerative Diseases
The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for ...
2007-104 Pending Lrrk2 Antibodies (Revised 6-19-2007)
Human leucine-rich repeat kinase 2 (Lrrk2) antibodies, raised to sequence peptides in rabbits and used to ...
2007-119 None TDP-43 Overexpressing Mice: A Transgenic Model of Dementia
TDP-43 is a major protein constituent of ubiquitin-positive inclusions in patients with dementia, including ...
2007-120 None mTau Overexpressing Mice: A Transgenic Model of Dementia
Accumulation of tau in neurofibrillary tangles is an important pathological indicator of several ...
2007-155 None Plasmodium Falciparum Signal Peptide Peptidase cDNA Plasmid Constructs
These are circular DNA plasmid constructs that encode for a gene called signal peptide peptidase. The gene ...
2007-166 None Detection of Cytochrome P450 (CYP) 2D7-CYP2D6 Recombinant Genes
This invention describes a method that allows for the detection of the CYP2D7-CYP2D6 recombinant gene. This ...
2007-172 Pending Method for Estimating Diversity of Receptors Expressed by Thymus-Derived Lymphocytes
Thymus-derived (T) lymphocytes are important for controlling infections and cancer. The ability to carry out ...
2007-230 None Human IAPP Knock-In Mouse
We have replace the mouse islet amyloid polypeptide (IAPP, amylin) gene with the human IAPP gene. Human IAPP ...
2007-235 None Cell Line Established from Ileal and Rectal Carcinoid Tumors
Carcinoids of the intestine are the most common gastrointestinal carcinoid tumors. Therapeutic options to ...
2007-246 None Monoclonal Antibody 4F3
4F3 is a mouse monoclonal anitbody against the protein Hsp90. It binds specifically to Hsp 90 from avian ...
2007-258 None Antibody to GALC
Monoclonal antibodies to GALC for use for disease research and as a histological lysosomal marker. ...
2007-259 None Generation of EBV-Transformed B-Cell Lines from CVID Patients with TACI Mutation
We have generated 2 B-cell lines from 2 individual CVID patients who have a specific mutation in the TACI ...
2007-288 None LRRK2 Knock Out Mice
Mice in which the endogenous leucine-rich repeat kinase 2 gene (LRRK2) has been ablated. Exon 41 has been ...
2007-300 None Recombinant Mature Form of Human Frataxin Protein
Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by a deficiency of frataxin, a ...
2007-323 None AbS1 a Monoclonal Antibody to GCUNC45
This is a monoclonal antibody against GCUNC45 (General Cell UNC45) also called SMAP-1 which has sequence ...
2007-324 None Monoclonal Antibody to tsp23 (transcript like p23)
This is a monoclonal antibody, produced in mice, to the human protein tsp23 which has sequence similarity to ...
2007-325 None Monoclonal Antibody JJ6
JJ6 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for ...
2007-326 None Monoclonal Antibody JJ12
JJ12 is a mouse monoclonal IgG antibody that was prepared against the human protein p23, a co-chaperone for ...
2007-327 None High-Throughput Cell-Based Assay for Lrrk2 Activity
Leucine-rich repeat kinase 2 (lrrk2) exits as a dimer, and with associated proteins probably forms a higher ...
2007-330 None iLRRK2 Wild-Type and Mutant (G2019S) Transgenic Mice
We created mice that contain human LRRK2 cDNA encoding either the wild-type or G2019S mutant form of the gene ...
2006-055 None Human Breast Cancer Cell Lines
We have developed unique breast cancer cell lines with inducible estrogen receptor isoforms (alpha and beta) ...
2006-059 None Antibodies Toward Intracellular Signaling Molecules: WAVE2, Ev1, VASP, HS1, STIM, CIN85 and TUBA
Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA ...
2006-100 None Assays for Detection of Malarial Signal Peptide Peptidase (SPP) Activity and Use in Identifying Novel Anti-Malarial Drugs
We have identified and synthesized a gene encoding a novel drug target in the malarial parasite (Plasmodium ...
2006-137 Pending A Novel Systems Biology Approach to Identify Subtle Disease Including Prediabetes Mellitus
A method has been developed for assessing an inter-dependent biological system wherein said methods comprise ...
2006-231 None Polyclonal Antibodies to the CRAC Regulators Orail and STIM1
Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) ...
2005-014 None Purified Rho Family GTP-binding Proteins
Proteins of the Rho family of GTP-binding proteins regulate multiple cellular phenomenon. There are 17 ...
2005-016 None rTg4510 Mouse Model of Tauopathy
These transgenic mice have regulatable tau expression and profound neurofibrillary pathology, ...
2005-031 Pending Mouse Anti-Human Caspase 8 p41 Monoclonal Antibody
A monoclonal antibody raised in a mouse specifically directed against the C-terminal end of the human protein ...
2005-107 None Stably Transfected Cell Lines Expressing APPwt or Alkaline Phosphatase-APP105 Fusion that Produce Extremely High Levels of Abeta42
These cell lines express a protein (APP) that is cleaved to form the Amyloid beta protein (Abeta) deposited ...
2005-127 None Antibodies to Isoforms of HP-1 and SP-1
Antibodies to various isoforms of HP-1 and SP-1. ...
2005-204 Pending Analytical Reconstruction of Unobserved Ensemble Signals in Biomedical Systems
The invention is a network of coupled equations with deterministic and stochastic features designed to ...
2005-231 None Prostate Marker Validation Database
Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a ...
2005-247 None MAPT (tau) cDNA Clones in pCDNA 3.1
MAPT (tau) is a protein involved in regulating the structure and function of nerve cells. The clones contain ...
2005-255 None pCT26, pFP93, pCT26sin
FIV vector components: transfer vectors (pCT26, pCT26sin) and packaging constructe (pFP93). ...
2005-293 None Anti-Abeta38 Selective Monoclonal Antibody
This antibody selectively recognizes the 38 amino acid from the amyloid beta peptide....
2005-316 None Ly9 (CD229) Knock Out Mice
These mice do not express the gene for CD229. ...
2004-022 None Genetically Modified Mice Susceptible to Pathogens Infection
Mice expressing human CD46 with human-like tissue specificity and efficiency. For additional information, ...
2004-062 None Osteoblast with Estrogen Receptor Isoform Homodimers and Heterodimers (alpha & beta)
We have developed osteosarcoma cell lines (U2OS) which express both the ER-alpha and ER-beta isoforms and ...
2004-108 None 51KO Mouse Line
The invention is a mouse line in which we disrupted the gene for FKBP51, a protein component of steroid ...
2004-109 None 52KO Mouse Line
This invention is a mouse line in which we disrupted the gene for FKBP52, a protein component of steroid ...
2004-133 None Advanced FIV Vector System
A highly engineered FIV vector system useful for delivering genes to cells....
2004-154 None GALV.fus Gene
Expression of GALV-fuse gene in tumor cells causes them to fuse with their nontransfected neighbors forming a ...
2004-181 Pending Method of Demonstrating the Presence of Fungi in Human Body Fluids
A research tool/method to detect the presence of fungal organisms in human body fluids, particularly from ...
2003-047 Patent Mouse Model of Glucose Intolerance and Role of Myosin Heavy Chain in Glucose Intolerance
Mayo Clinic researchers have developed a novel transgenic mouse model that exhibits symptoms of glucose ...
2003-071 None Doxycycline-inducible Estrogen Receptor-alpha and -beta Human U2OS Osteosarcoma Cell Lines
These cells allow the investigator to examine the effects of estrogen receptor (ER)-alpha or ER-beta on the ...
2003-107 None Use of Specific Estrogen-regulated Genes in U2OS-ERa, U2OS-ERb, and U2OS-ERa/b Osteoblasts as Markers
We have conducted microarray chip analysis of estrogen-regulated genes in the U2OS0ERa, -ERb, and -ERa/b ...
2003-108 Patent Unique Phenotype of TIEG Knockout Mice
We have developed mice which contain a disruption in a nucleic acid encoding TIEG. The mice develop cardiac ...
2003-126 Pending Radiolabeled Thymidine Solid-Phase Extraction Purification Method
This solid-phase extraction purification method can purify radiolabeled thymidine quickly and conveniently. ...
2003-150 Patent An IEX-1 Null Mutant Mouse
A mouse lacking both copies of the IEX-1 gene was generated. These mice have a mean arterial blood pressure ...
2003-196 None Transgenic Line of Mice Congenitally Devoid of Eosinophils
Transgenic mice were created through DNA microinjection of a construct utilizing mouse EPO derived regulatory ...
2003-222 Patent Transgenic Mice Expressing Mutant Protein Kinase C lota in the Colonic Epithelium
Atypical Protein Kinase-C iota (PKCi) has been implicated as an oncogene in several cancer types. Mayo Clinic ...
2002-039 Patent ICOS Mutants
This invention relates to T cell-mediate immune responses, and more particularly to compositions and methods ...
2002-098 None An Auto-regulated Doxycycline-inducible FIV-based Lentiviral Vector
This invention allows 1) inducible and regulated expression of a gene of interest from an integrated feline ...
2002-115 None 2B7: A Chinese Hamster Ovary Cell Line Expressing High Levels of Human Amyloid Beta Protein Precursor
This cell line is a stably transfected Chinese hamster ovary (CHO) cell line. It is transfected with the ...
2002-116 None H4 wt APP Cells (H4 Cell Line)
H4 cell line stably transfected with an APP695wt clone in the pCDNA3 vector....
2002-121 None Monoclonal Antibody B4-78
A monoclonal antibody that interacts with the liver and bone isoenzymes of human alkaline phosphatase....
2001-023 Patent BRI-ABeta Fusion Proteins: A Novel Means for Specific High-Level Expression of ABeta Peptides
A novel expression system has been developed that selectively expresses ABeta40 or ABeta42 in the secretory ...
2001-039 Patent Solid-Phase Synthesis Using Chlorotrityl Resins
Mayo has developed methods for loading amino derivatives onto chlorotrityl resins. ...
2001-113 Patent Genetically-Engineered Mouse Line with PAPP-A Gene Deletion
Development of a line of mice homozygous for targeted disruption of the pregnancy-associated plasma protein-A ...
2001-158 Patent Display of Polypeptides on the Envelope Glycoproteins of Avian Leukosis Viruses
The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides ...
2000-007 Patent Double Subtractive mRNA Fingerprinting (DSF)
Subtraction of mRNAs is first performed by a novel method. The subtracted mRNAs are then subjected to ...
2000-008 Patent Preferential Amplification from Coding Sequences
With specially designed primers, segments from the coding region of mRNAs is amplified by Polymerase Chain ...
2000-023 None Feline Immunodeficiency Virus (FIV) Transfer Vectors CT23 and CT25a
This new lentiviral transfer vector with a minimal portion of the gag open reading frame and a versatile ...
2000-064 None HLA-DR3.Abo Transgenic Mice
We developed an HLA-DR3.Abo mouse by introducing the DR3 transgene into a H2Abo mouse, class II negative ...
2000-065 Patent HLA-DQ8/DR3.Abo Transgenic Line
Mouse class II-deficient HLA-DQB1*0302, DQA1*0301 (DQ8) transgenic mice are susceptible to severe ...
2000-066 Patent Transgenic Mice Expressing Human Tau with the P301L Mutation
We have created two lines of transgenic mice expressing human tau with the P301L mutation. Mice expressing ...
2000-170 None Central Polypurine Tract (CPPT) and Central Termination Sequence (CTS) of Feline Immunodeficiency Virus and FIV Vectors Containing These Elements
The FIV CPPT and CTS were identified by a combination of molecular techniques and shown to augment FIV vector ...
1999-064 None Anti-murine Major Basic Protein-1 Polyclonal (rabbit) Antisera
Investigators have developed a rabbit polyclonal antisera reactive against murine major basic protein-1 ...
1999-065 None Mouse Monoclonal Antibodies Against Murine Eosinophil Peroxidase (mEPO)
Investigators are combining mEPO and together with mEPO deficient gene knock-out animals to create a battery ...
1998-008 None Collection of Genotyped Vancomycin Resistant Enterococci
Collection of 36 genotyped vancomycin-resistant enterococci including vanA, vanB, vanC, and vanC2-3 ...
1998-025 Pending Hormone-Related Polyclonal Antibodies
N-Terminal polyclonal affinity purified PTH, polyclonal antibody, PTH-related antibody proinsulin-polyclonal, ...
1998-026 Patent Mutations in the Microtubule Associated Protein tau Cause Neurodegenerative Disease
Mutations in the tau gene have been discovered that are linked to Tau pathologies. Identification of these ...
1998-038 None Eosinophil-specific Promoter
Investigators have isolated regulatory sequences from the murine EPO gene that permit eosinophil-lineage ...
1997-035 None ZAP-70-Deficient T-cell Activation Model
This technology is a T-cell line that lacks the protein tyrosine kinase, ZAP-70. ZAP-70 plays a critical ...
1997-069 None Transgenic Mouse Line HLA-DR2
We developed an HLA-DR2 mouse model by introducing a human DRB1*1502(DR2DW12) transgene into CIA susceptible ...
1997-071 None HLA-DR4 (DRB1*0401) Transgenic Mice
We generated an HLA-DR4ß(NT) transgene construct in which positions 110 and 139 were altered to resemble ...
1997-072 None Transgenic Mouse Line HLA-DQ6
We generated mice transgenic for HLA-DQ6, an allele associated with a nonsusceptible haplotype. These mice ...
1997-106 None Establishment of Human Myeloma Cell Lines
Mayo researchers have established several human multiple myeloma cell lines, including the ANBL-6 line....
1997-112 None A Preclinical Mouse Model for use in MUC1 Immunotherapy Protocols
An inbred strain of transgenic mice that show tissue-specific expression of the human MUC1 gene. These ...
1997-123 None Identification of Genes with Diagnostic or Therapeutic Potential in a Population Based Cohort of Patients with Ulcerative Colitis and Crohn's Disease
Creating an electronic database of an entire population of patients with Crohn's disease and ulcerative ...
1996-076 Patent Transgenic Mouse Model for Alzheimer's Disease
Transgenic mouse (Tg2576) carrying the Swedish mutation for Alzheimer?s Disease. This mouse was developed by ...
1996-085 Patent A New Imaging Method with Limited Diffraction Beams
A new imaging method has been developed that allows 3D imaging in a very high frame rate. The method can also ...
1996-109 None Monoclonal Antibodies to Basophils
We have developed mouse monoclonal antibodies that bind to basophils, a type of cell that circulates in the ...
1995-072 Patent TIEG: A Novel TGFß-Estrogen Regulated Early Gene Expressed in Osteoblasts, Breast Tissues and Other Cell and Tissue Types
A marker for detecting breast cancer and implications for pancreatic cancer. The novel TGFß/estrogen ...
1995-087 None Open Reading Frame Gene Sequence of the Kappa Opioid Receptor from Human Brain
The base sequence coding for the protein of the human kappa opioid receptor, the deduced amino acid sequence ...
1995-110 Patent New Radiolabeled Markers for the Measurement of Colonic Transit
These radiolabeled agents are designed to allow for simple preparation of radioactive markers for measuring ...
1995-138 Patent The Ker14/IL5 Transgenic Mouse is a Model for Eosinophil-mediated Cutaneous Disease.
Transgenic mouse models for allergic skin disorders were developed that express interleukin-5 under the ...
1995-139 Patent NJ1638 Mice ? Hypereosinophilic Transgenic Mice
Transgenic mouse models for eosinophil-mediated tissue inflammation were developed that express interleukin-5 ...
1995-140 Patent The CCIL5 Transgenic Mouse is a Model for Asthma and Eosinophilic Pulmonary Inflammation
Transgenic mouse models for asthma were developed that express interleukin-5 under the control of a lung ...
1995-155 Patent Transfected Human Fetal Osteoblast (FOB) Cell Lines with Estrogen Receptors
HFOBER cells are hFOBs stably transfected with human estrogen receptor; subclones HFOB/ER-3 and HFOB/ER-4 ...
1993-010 Patent Human Fetal Osteoblast Progenitor Cells Lines (hFOB)
Conditionally Immortalized Human Osteoblastic Cell Line: Normal human bone cells were stably transfected ...
1993-030B Patent Stably-transformed cells expressing human thiopurine methyltransferase
Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs ...
1993-058 None Human Neurotensin Receptor Polymorphism and Gene Encoding Same
Open reading frame gene sequence of the neurotensin receptors from human brain tissue....
1988-049 None Immature Human Mast Cell Line HMC-1
HMC-1 is a one-of-a kind human cell line which can serve as a resource for mast cell proteins including ...
1987-046 Patent BU-1 Antibody
Monoclonal Antibody to Bromo-deoxy-uridine. Useful in cell proliferation kits...