| Reference # |
Patent
Status |
Description |
| 2008-016 |
None
|
Anti-SINA/SIAH Monoclonal Antibodies & Related Know-How
Four mouse anti-SINA/SIAH monoclonal antibodies are available for licensing. Details are as follows. Two ...
|
| 2007-003 |
None
|
A New Cytochrome P450 2D6 (CYP2D6) Allele
A new allele resulting from a crossover between two genes known as cytochrome P450 2D6 (CYP2D6) and the ...
|
| 2007-016 |
None
|
Transgenic Mouse Expressing P1 Artificial Chromosome (PAC) Containing the Entire Human Alpha-Synuclein (SNCA) Gene
Tansgenic mouse that over-expresses the human alpha-synuclein gene, under the control of its endogenous human ...
|
| 2007-027 |
None
|
LRRK2 BAC Transgenic Mice: A Model of Parkinsonism
Mice that over-express the human wild-type and mutant leucine-rich repeat kinase 2 gene (LRRK2)....
|
| 2007-050 |
Pending
|
Establishment and Characterization of an Immunoglobulin Lambda Secreting Cell Line from AL Amyloidsis
The ALMC-1 and ALMC-2 cell lines were established from samples before and after peripheral blood stem cell ...
|
| 2007-079 |
Pending
|
Staphylococcus Lugdunensis Hypothetical Glycosyl Hydrolase
The Staphylococcus lugdunensis hypothetical glycosyl hydrolase is the predicted gene product of an open ...
|
| 2007-103 |
Pending
|
In Vitro and In Vivo Models of TDP-43 and TDP-43 as Biomarker for Neurodegenerative Diseases
The abnormal accumulation of TDP-43 protein has been recently identified as the major protein constituent for ...
|
| 2007-104 |
None
|
Lrrk2 Antibodies (Revised 6-19-2007)
Human leucine-rich repeat kinase 2 (Lrrk2) antibodies, raised to sequence peptides in rabbits and used to ...
|
| 2007-119 |
None
|
TDP-43 Overexpressing Mice: A Transgenic Model of Dementia
TDP-43 is a major protein constituent of ubiquitin-positive inclusions in patients with dementia, including ...
|
| 2007-120 |
None
|
mTau Overexpressing Mice: A Transgenic Model of Dementia
Accumulation of tau in neurofibrillary tangles is an important pathological indicator of several ...
|
| 2007-155 |
None
|
Plasmodium Falciparum Signal Peptide Peptidase cDNA Plasmid Constructs
These are circular DNA plasmid constructs that encode for a gene called signal peptide peptidase. The gene ...
|
| 2007-166 |
None
|
Detection of Cytochrome P450 (CYP) 2D7-CYP2D6 Recombinant Genes
This invention describes a method that allows for the detection of the CYP2D7-CYP2D6 recombinant gene. This ...
|
| 2007-172 |
Pending
|
Method for Estimating Diversity of Receptors Expressed by Thymus-Derived Lymphocytes
Thymus-derived (T) lymphocytes are important for controlling infections and cancer. The ability to carry out ...
|
| 2007-230 |
None
|
Human IAPP Knock-In Mouse
We have replace the mouse islet amyloid polypeptide (IAPP, amylin) gene with the human IAPP gene. Human IAPP ...
|
| 2007-235 |
None
|
Cell Line Established from Ileal and Rectal Carcinoid Tumors
Carcinoids of the intestine are the most common gastrointestinal carcinoid tumors. Therapeutic options to ...
|
| 2007-240 |
None
|
Dominant Negative SINA/SIAH Cell Lines and Transgenic Mouse Lines
A number of stable human pancreatic cancer cell lines (MiaPaCa and Panc-1) have been generated that expressed ...
|
| 2007-244 |
None
|
Monoclonal Antibody PR11
PR11 is a mouse monoclonal antibody against the progesterone receptor protein. It binds specifically to ...
|
| 2007-246 |
None
|
Monoclonal Antibody 4F3
4F3 is a mouse monoclonal anitbody against the protein Hsp90. It binds specifically to Hsp 90 from avian ...
|
| 2007-258 |
None
|
Antibody to GALC
Monoclonal antibodies to GALC for use for disease research and as a histological lysosomal marker. ...
|
| 2007-259 |
None
|
Generation of EBV-Transformed B-Cell Lines from CVID Patients with TACI Mutation
We have generated 2 B-cell lines from 2 individual CVID patients who have a specific mutation in the TACI ...
|
| 2007-288 |
None
|
LRRK2 Knock Out Mice
Mice in which the endogenous leucine-rich repeat kinase 2 gene (LRRK2) has been ablated. Exon 41 has been ...
|
| 2007-300 |
None
|
Recombinant Mature Form of Human Frataxin Protein
Friedreich ataxia (FRDA) is an autosomal recessive degenerative disease caused by a deficiency of frataxin, a ...
|
| 2007-323 |
None
|
AbS1 a Monoclonal Antibody to GCUNC45
This is a monoclonal antibody against GCUNC45 (General Cell UNC45) also called SMAP-1 which has sequence ...
|
| 2007-324 |
None
|
Monoclonal Antibody to tsp23 (transcript like p23)
This is a monoclonal antibody, produced in mice, to the human protein tsp23 which has sequence similarity to ...
|
| 2007-327 |
None
|
High-Throughput Cell-Based Assay for Lrrk2 Activity
Leucine-rich repeat kinase 2 (lrrk2) exits as a dimer, and with associated proteins probably forms a higher ...
|
| 2007-330 |
None
|
iLRRK2 Wild-Type and Mutant (G2019S) Transgenic Mice
We created mice that contain human LRRK2 cDNA encoding either the wild-type or G2019S mutant form of the gene ...
|
| 2006-042 |
Pending
|
A System for Monitoring Ligand-dependent and Ligand-independent Androgen Receptor Activity
The androgen receptor is a protein that mediates androgen signaling in the body. In prostate cells, for ...
|
| 2006-055 |
None
|
Human Breast Cancer Cell Lines
We have developed unique breast cancer cell lines with inducible estrogen receptor isoforms (alpha and beta) ...
|
| 2006-059 |
None
|
Antibodies Toward Intracellular Signaling Molecules: WAVE2, Ev1, VASP, HS1, STIM, CIN85 and TUBA
Peptide or GST-fusion proteins containing antigenic epitopes of WAVE2, Evl, VASP, HS1, STIM, CIN85 and TUBA ...
|
| 2006-100 |
None
|
Assays for Detection of Malarial Signal Peptide Peptidase (SPP) Activity and Use in Identifying Novel Anti-Malarial Drugs
We have identified and synthesized a gene encoding a novel drug target in the malarial parasite (Plasmodium ...
|
| 2006-231 |
None
|
Polyclonal Antibodies to the CRAC Regulators Orail and STIM1
Rabbit polyclonal antibodies were generated to two components of the calcium-release activated calcium (CRAC) ...
|
| 2005-014 |
None
|
Purified Rho Family GTP-binding Proteins
Proteins of the Rho family of GTP-binding proteins regulate multiple cellular phenomenon. There are 17 ...
|
| 2005-016 |
Pending
|
rTg4510 Mouse Model of Tauopathy
These transgenic mice have regulatable tau expression and profound neurofibrillary pathology, ...
|
| 2005-088 |
None
|
Quality Control Measures for Genotyping Polymorphic Genes
Polymorphic genes pose problems for genotyping measurements when PCR amplification is involved. Mutations ...
|
| 2005-104 |
None
|
Stealth and Targeted Envelope for Vector Delivery
Several human viruses are being developed as novel agents for the treatment of human cancer even if ...
|
| 2005-107 |
None
|
Stably Transfected Cell Lines Expressing APPwt or Alkaline Phosphatase-APP105 Fusion that Produce Extremely High Levels of Abeta42
These cell lines express a protein (APP) that is cleaved to form the Amyloid beta protein (Abeta) deposited ...
|
| 2005-127 |
None
|
Antibodies to Isoforms of HP-1 and SP-1
Antibodies to various isoforms of HP-1 and SP-1.
...
|
| 2005-204 |
Pending
|
Analytical Reconstruction of Unobserved Ensemble Signals in Biomedical Systems
The invention is a network of coupled equations with deterministic and stochastic features designed to ...
|
| 2005-231 |
None
|
Prostate Marker Validation Database
Under the Minnesota Partnership, researchers at the University of Minnesota and at Mayo have developed a ...
|
| 2005-247 |
None
|
MAPT (tau) cDNA Clones in pCDNA 3.1
MAPT (tau) is a protein involved in regulating the structure and function of nerve cells. The clones contain ...
|
| 2005-255 |
None
|
pCT26, pFP93, pCT26sin
FIV vector components: transfer vectors (pCT26, pCT26sin) and packaging constructe (pFP93).
...
|
| 2005-316 |
None
|
Ly9 (CD229) Knock Out Mice
These mice do not express the gene for CD229.
...
|
| 2004-022 |
None
|
Genetically Modified Mice Susceptible to Pathogens Infection
Mice expressing human CD46 with human-like tissue specificity and efficiency. For additional information, ...
|
| 2004-061 |
None
|
Polyclonal Antibodies Specific for SRC-2 and REA Steroid Receptor Coregulators
We have developed a series of polyclonal antibodies specific for SRC-2 and REA steroid receptor coregulators. ...
|
| 2004-062 |
None
|
Osteoblast with Estrogen Receptor Isoform Homodimers and Heterodimers (alpha & beta)
We have developed osteosarcoma cell lines (U2OS) which express both the ER-alpha and ER-beta isoforms and ...
|
| 2004-108 |
None
|
51KO Mouse Line
The invention is a mouse line in which we disrupted the gene for FKBP51, a protein component of steroid ...
|
| 2004-109 |
None
|
52KO Mouse Line
This invention is a mouse line in which we disrupted the gene for FKBP52, a protein component of steroid ...
|
| 2004-133 |
None
|
Advanced FIV Vector System
A highly engineered FIV vector system useful for delivering genes to cells....
|
| 2004-154 |
None
|
GALV.fus Gene
Expression of GALV-fuse gene in tumor cells causes them to fuse with their nontransfected neighbors forming a ...
|
| 2004-158 |
Pending
|
Transgenic Mouse Model of HCV Infection
Mayo Clinic Researchers have developed a novel transgenic mouse that contains transplanted human hepatocytes ...
|
| 2004-181 |
Pending
|
Method of Demonstrating the Presence of Fungi in Human Body Fluids
A research tool/method to detect the presence of fungal organisms in human body fluids, particularly from ...
|
| 2004-291 |
Pending
|
Identification of a Novel LRRK2 Mutation, 6055G>A (G2019S), Linked to Autosomal Dominant Parkinsonism in Families from Several European Populations
Autosomal dominant parkinsonism linked to chromosome 12q12 (PARK8) has recently been attributed to pathogenic ...
|
| 2003-023 |
None
|
Apparatus and Means to Measure Vessel Stiffness
Ultrasonic radiation pressure is used to induce surface waves in the wall of a vessel. The speed and ...
|
| 2003-047 |
|
Mouse Model of Glucose Intolerance and Role of Myosin Heavy Chain in Glucose Intolerance
Mayo Clinic researchers have developed a novel transgenic mouse model that exhibits symptoms of glucose ...
|
| 2003-108 |
|
Unique Phenotype of TIEG Knockout Mice
We have developed mice which contain a disruption in a nucleic acid encoding TIEG. The mice develop cardiac ...
|
| 2003-150 |
|
An IEX-1 Null Mutant Mouse
A mouse lacking both copies of the IEX-1 gene was generated. These mice have a mean arterial blood pressure ...
|
| 2003-196 |
Pending
|
Transgenic Line of Mice Congenitally Devoid of Eosinophils
Transgenic mice were created through DNA microinjection of a construct utilizing mouse EPO derived regulatory ...
|
| 2003-222 |
Pending
|
Transgenic Mice Expressing Mutant Protein Kinase C lota in the Colonic Epithelium
These mice represent a model for colon cancer progression from adenoma to carcinoma. C57BI/6J mice were ...
|
| 2002-039 |
|
ICOS Mutants
This invention relates to T cell-mediate immune responses, and more particularly to compositions and methods ...
|
| 2002-098 |
None
|
An Auto-regulated Doxycycline-inducible FIV-based Lentiviral Vector
This invention allows 1) inducible and regulated expression of a gene of interest from an integrated feline ...
|
| 2002-115 |
None
|
2B7: A Chinese Hamster Ovary Cell Line Expressing High Levels of Human Amyloid Beta Protein Precursor
This cell line is a stably transfected Chinese hamster ovary (CHO) cell line. It is transfected with the ...
|
| 2002-116 |
None
|
H4 wt APP Cells (H4 Cell Line)
H4 cell line stably transfected with an APP695wt clone in the pCDNA3 vector....
|
| 2002-203 |
None
|
MRSA and MSSA Osteomyelitis Strains
MRSA and MSSA Osteomyelitis Strains...
|
| 2001-023 |
Pending
|
BRI-ABeta Fusion Proteins: A Novel Means for Specific High-Level Expression of ABeta Peptides
A novel expression system has been developed that selectively expresses ABeta40 or ABeta42 in the secretory ...
|
| 2001-039 |
Pending
|
Solid-Phase Synthesis Using Chlorotrityl Resins
Mayo has developed methods for loading amino derivatives onto chlorotrityl resins.
...
|
| 2001-113 |
|
Genetically-Engineered Mouse Line with PAPP-A Gene Deletion
Development of a line of mice homozygous for targeted disruption of the pregnancy-associated plasma protein-A ...
|
| 2001-129 |
Pending
|
Measurement of Shear Modulus
A new method is proposed to measure the shear elasticity and shear viscosity at an optically clear material. ...
|
| 2001-158 |
|
Display of Polypeptides on the Envelope Glycoproteins of Avian Leukosis Viruses
The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides ...
|
| 2000-001 |
|
A Transcriptionally Active Promoter-Gene System with Intrinsic Immunotherapeutic Benefit
The invention uses a constitutively active form of the Heat Shock Factor-1 (HSF-1) transcription factor to ...
|
| 2000-023 |
None
|
Feline Immunodeficiency Virus (FIV) Transfer Vectors CT23 and CT25a
This new lentiviral transfer vector with a minimal portion of the gag open reading frame and a versatile ...
|
| 2000-064 |
None
|
HLA-DR3.Abo Transgenic Mice
We developed an HLA-DR3.Abo mouse by introducing the DR3 transgene into a H2Abo mouse, class II negative ...
|
| 2000-065 |
|
HLA-DQ8/DR3.Abo Transgenic Line
Mouse class II-deficient HLA-DQB1*0302, DQA1*0301 (DQ8) transgenic mice are susceptible to severe ...
|
| 2000-066 |
|
Transgenic Mice Expressing Human Tau with the P301L Mutation
We have created two lines of transgenic mice expressing human tau with the P301L mutation. Mice expressing ...
|
| 2000-100 |
|
Genetic Polymorphisms in the Human 3'-phosphoadenosine 5'-phosphosulfate Synthetase 2 (PAPSS2) Gene
PAPSS2 is an enzyme that synthesizes PAPS; the high-energy sulfate donor molecule involved in the sulfate ...
|
| 2000-170 |
None
|
Central Polypurine Tract (CPPT) and Central Termination Sequence (CTS) of Feline Immunodeficiency Virus and FIV Vectors Containing These Elements
The FIV CPPT and CTS were identified by a combination of molecular techniques and shown to augment FIV vector ...
|
| 1999-026 |
None
|
Establishment of Secretin Receptor-Bearing Cell Lines
We have established Chinese hamster ovary cell lines expressing the secretin receptor. This permits the ...
|
| 1999-064 |
None
|
Anti-murine Major Basic Protein-1 Polyclonal (rabbit) Antisera
Investigators have developed a rabbit polyclonal antisera reactive against murine major basic protein-1 ...
|
| 1999-065 |
None
|
Mouse Monoclonal Antibodies Against Murine Eosinophil Peroxidase (mEPO)
Investigators are combining mEPO and together with mEPO deficient gene knock-out animals to create a battery ...
|
| 1998-008 |
None
|
Collection of Genotyped Vancomycin Resistant Enterococci
Collection of 36 genotyped vancomycin-resistant enterococci including vanA, vanB, vanC, and vanC2-3 ...
|
| 1998-009 |
|
Immunotherapy of Plasmaproliferative Disorders Utilizing an Antibody Engineered scFv
Multiple myeloma is a universally fatal plasmaproliferative disorder despite aggressive chemotherapy and ...
|
| 1998-038 |
None
|
Eosinophil-specific Promoter
Investigators have isolated regulatory sequences from the murine EPO gene that permit eosinophil-lineage ...
|
| 1998-039 |
|
mMBP-1 deficient Mice
Through the use of gene targeting in mouse embryonic stem (ES) cells we have sucessfully generated a line of ...
|
| 1998-071 |
|
SULT1A1 and 1A2 Pharmacogenomics
Substrates for SULT1A1 are; 4-nitrophenol, 17beta-estradiol (E2), diethylstilboestrol (DES), 1-naphol, ...
|
| 1997-035 |
None
|
ZAP-70-Deficient T-cell Activation Model
This technology is a T-cell line that lacks the protein tyrosine kinase, ZAP-70. ZAP-70 plays a critical ...
|
| 1997-069 |
None
|
Transgenic Mouse Line HLA-DR2
We developed an HLA-DR2 mouse model by introducing a human DRB1*1502(DR2DW12) transgene into CIA susceptible ...
|
| 1997-071 |
None
|
HLA-DR4 (DRB1*0401) Transgenic Mice
We generated an HLA-DR4ß(NT) transgene construct in which positions 110 and 139 were altered to resemble ...
|
| 1997-072 |
None
|
Transgenic Mouse Line HLA-DQ6
We generated mice transgenic for HLA-DQ6, an allele associated with a nonsusceptible haplotype. These mice ...
|
| 1997-106 |
None
|
Establishment of Human Myeloma Cell Lines
Mayo researchers have established several human multiple myeloma cell lines, including the ANBL-6 line....
|
| 1997-112 |
None
|
A Preclinical Mouse Model for use in MUC1 Immunotherapy Protocols
An inbred strain of transgenic mice that show tissue-specific expression of the human MUC1 gene. These ...
|
| 1996-076 |
|
Transgenic Mouse Model for Alzheimer's Disease
Transgenic mouse (Tg2576) carrying the Swedish mutation for Alzheimer?s Disease. This mouse was developed by ...
|
| 1996-103 |
None
|
Cloning of the cDNA for the Human Cholecystokinin A Receptor and Establishment of a Receptor-bearing Cell Line
We have cloned the cDNA for the human cholecystokinin A receptor from a gallbladder cDNA library, and ...
|
| 1996-109 |
None
|
Monoclonal Antibodies to Basophils
We have developed mouse monoclonal antibodies that bind to basophils, a type of cell that circulates in the ...
|
| 1996-121 |
|
The Pneumocystis Carinii Cell Division Cycle - 2 (cdc2) Genomic and cDNA Clones
Pneumocystis carinii is an opportunistic fungus that causes an often fatal pneumonia in individuals with ...
|
| 1995-017 |
|
A Peptide Based Vaccine for Prevention and Cure of Rheumatoid Arthritis
Generation of synthetic peptides (15-20 amino acids) that will specifically bind to the major ...
|
| 1995-087 |
None
|
Open Reading Frame Gene Sequence of the Kappa Opioid Receptor from Human Brain
The base sequence coding for the protein of the human kappa opioid receptor, the deduced amino acid sequence ...
|
| 1995-138 |
None
|
The Ker14/IL5 Transgenic Mouse is a Model for Eosinophil-mediated Cutaneous Disease.
Transgenic mouse models for allergic skin disorders were developed that express interleukin-5 under the ...
|
| 1995-139 |
|
NJ1638 Mice ? Hypereosinophilic Transgenic Mice
Transgenic mouse models for eosinophil-mediated tissue inflammation were developed that express interleukin-5 ...
|
| 1995-140 |
|
The CCIL5 Transgenic Mouse is a Model for Asthma and Eosinophilic Pulmonary Inflammation
Transgenic mouse models for asthma were developed that express interleukin-5 under the control of a lung ...
|
| 1995-155 |
|
Transfected Human Fetal Osteoblast (FOB) Cell Lines with Estrogen Receptors
HFOBER cells are hFOBs stably transfected with human estrogen receptor; subclones HFOB/ER-3 and HFOB/ER-4 ...
|
| 1994-072 |
|
Isolated DNA Encoding Human Liver Estrogen Sulfotransferase
The invention provides an isolated and purified human DNA molecule that encodes human estrogen ...
|
| 1993-010 |
|
Human Fetal Osteoblast Progenitor Cells Lines (hFOB)
Conditionally Immortalized Human Osteoblastic Cell Line: Normal human bone cells were stably transfected ...
|
| 1993-030 |
|
Human Thiopurine Methyltransferase (TPMT) Gene Discovery
Human Thiopurine Methyltransferase (TPMT) Gene Discovery. Catalyzes the S-methylation of thiopurine drugs ...
|
| 1993-058 |
None
|
Human Neurotensin Receptor Polymorphism and Gene Encoding Same
Open reading frame gene sequence of the neurotensin receptors from human brain tissue....
|
| 1988-049 |
None
|
Immature Human Mast Cell Line HMC-1
HMC-1 is a one-of-a kind human cell line which can serve as a resource for mast cell proteins including ...
|
