ZAP-70-Deficient T-cell Activation Model

Reference #:

1997-035

Inventors/Contributors

Robert T. Abraham, Ph.D., Brandi L. Williams

Description

This technology is a T-cell line that lacks the protein tyrosine kinase, ZAP-70. ZAP-70 plays a critical role in the initiation of lymphocyte activation responses to antigenic stimuli. The cell line can be used to define the mechanisms of ZAP-70 activation and function in T-cell signaling. This line can be used also to confirm the mechanism of action of ZAP-70 targeted drugs. This is the first genetically manipulatable T-cell model system that lacks the critical protein tyrosine kinase, ZAP-70.

Patent Status

None