mMBP-1 deficient Mice

Reference #:

1998-039

Inventors/Contributors

James J. Lee, M.D., Ph.D., Nancy A. Lee, M.D., Ph.D.

Description

Through the use of gene targeting in mouse embryonic stem (ES) cells we have sucessfully generated a line of mice deficient in eosinophil granule major basic protein-1 (mMBP-1). These mice would be useful in drug discovery programs directed toward developing treatments for asthma, allergy, inflammation and a variety of eosinophil-related disorders.

Patent Status

	U.S. Patent Number 6,177,610 Issued January 23, 2001