Genetically-Engineered Mouse Line with PAPP-A Gene Deletion

Reference #:

2001-113

Inventors/Contributors

Cheryl A. Conover, Ph.D., Jan M.A. van Deursen, Ph.D.

Description

Development of a line of mice homozygous for targeted disruption of the pregnancy-associated plasma protein-A (PAPP-A) gene. These mice represent a model for determining the role of PAPP-A in growth promoting, non-pregnant states, such as vascular restenosis, atherosclerosis, wound healing, fibrosis, bone development, longevity and fracture repair as well as pregnancy related conditions such as fetal development and risk for low birth weights in offspring.

Patent Status

	U.S. Patent Number 7,402,724 Issued December 15, 2002 U.S. Patent Number 7,220,892 Issued May 22, 2007