Display of Polypeptides on the Envelope Glycoproteins of Avian Leukosis Viruses

Reference #:

2001-158

Inventors/Contributors

Mark J. Federspiel, Ph.D., Stephen J. Russell, M.D., Ph.D., Pranay D. Khare, Ph.D.

Description

The Avian Leukosis Virus (AVL) group of retroviruses offers a novel platform for the display of polypeptides and offers novel applications for polypeptide display technology. The ability to display polypeptides on the ALV envelope glycoproteins in a replicating retrovirus with an additional expression cassette presents several unique approaches to use this display platform to probe the interactions and /or co-evolution between a displayed polypeptide and a second protein encoded by an additional gene. Several combinations of the displayed polypeptide(s) and an additional gene(s) can be envisioned: (1) a library of polypeptides displayed on surface glycoproteins and a single additional gene; (2) a single displayed polypeptide on surface glycoproteins and a library of additional genes; (3) both a library of polypeptides displayed on surface glycoproteins and a single additional gene; (4) a single displayed polypeptide on surface glycoproteins and a library of additional genes; and (5) both a library of polypeptides displayed on surface glycoproteins and a library of additional genes.

Patent Status

	U.S. Patent Number 7,132,237 Issued November 07, 2006