Unique Phenotype of TIEG Knockout Mice

Reference #:

2003-108

Inventors/Contributors

Thomas C. Spelsberg, Ph.D., Malayannan Subramaniam, Ph.D., Nalini M. Rajamannan, M.D., Merry Jo Oursler, Ph.D.

Description

We have developed mice which contain a disruption in a nucleic acid encoding TIEG. The mice develop cardiac hypertrophy during aging and also have defects in osteoblast & osteoclast differentiation and function which can lead to defects in bone formation. These mice also can exhibit connective tissue defects. As a result, they provide a model to study the biological role of TIEG in diverse biological systems.

Patent Status

	U.S. Patent Number 7,304,203 Issued December 04, 2007