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Reference #:
2004-062
Inventors/Contributors
Thomas C. Spelsberg, Ph.D., David G. Monroe, Ph.D.
Description
We have developed osteosarcoma cell lines (U2OS) which express both the ER-alpha and ER-beta isoforms and display both ER-beta homodimers and ER-alpha/beta heterodimers, but no ER-alpha homodimers. These ER-alpha/beta cell lines are in a ratio which mimics that found in mature osteoblast and thus, it is speculated that these cells would respond to estrogens and selective estrogen receptor modulators (SERMs) as mature osteoblast would. These cells should be most useful for the analysis of new drugs, SERMs and growth factor cytokine analogues.
Patent Status
None |
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Contact
Julie A. Henry, Licensing Manager
henry.julie@mayo.edu
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Mayo Foundation for Medical Education and Research
Office of Technology Commercialization
Centerplace 4
200 First Street SW
Rochester, MN 55905
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Phone: (507) 266-4585
Fax: (507) 284-5410
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