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Reference #:
2007-016
Inventors/Contributors
Matthew J. Farrer Ph.D., Heather L. Melrose Ph.D., Sarah J. Lincoln
Description
Tansgenic mouse that over-expresses the human alpha-synuclein gene, under the control of its endogenous human promoter and regulatory elements. Genomic multiplication of the SNCA locus in humans, that leads to three or four copies of the gene (rather than the normal diploid copy number) result in Parkinson's disease with subsequent dementia, with post-mortem transitional or diffuse Lewy body pathology.
Patent Status
None |
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Contact
Susan L. Stoddard, Ph.D., Licensing Manager
sstoddard@mayo.edu
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Mayo Foundation for Medical Education and Research
Office of Technology Commercialization
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Rochester, MN 55905
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Phone: (507) 284-1222
Fax: (507) 284-5410
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