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Reference #:
2007-119
Inventors/Contributors
Eileen M. McGowan Ph.D., Michael L. Hutton Ph.D.
Description
TDP-43 is a major protein constituent of ubiquitin-positive inclusions in patients with dementia, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD). The mislocalization of TDP-43 from the nucleus to cytoplasmic inclusions in disease states is not well understood. Mice that overexpress human TDP-43 were generated in order to study the effects of this protein on mouse phenotype and neuropathology.
Patent Status
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Contact
Susan L. Stoddard, Ph.D., Licensing Manager
sstoddard@mayo.edu
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