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Reference #:
2007-120
Inventors/Contributors
Eileen M. McGowan Ph.D., Michael L. Hutton Ph.D., Stephanie J. Adams Ph.D., Richard Crook
Description
Accumulation of tau in neurofibrillary tangles is an important pathological indicator of several neurodegenerative diseases. Neurofibrillary pathology in Alzheimer’s disease (AD) results from aggregation and deposition of wild-type tau proteins. Aggregation of tau in mouse models has previously been studied by overexpressing human tau. However, mouse and human tau are slightly different and may affect each other’s aggregation. In order to better study the aggregration of mouse tau (mtau) protein, transgenic mice overexpressing mtau were generated. Characterization of the mtau mice has revealed that they form insoluble tau aggregates as early as 3 months of age. The pathology and phenotype of these mice will be further evaluated, and these mice will provide a model for studying the mechanisms of tau pathogenesis and a means of analyzing potential therapeutic targets.
Patent Status
None |
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Contact
Susan L. Stoddard, Ph.D., Licensing Manager
sstoddard@mayo.edu
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Mayo Foundation for Medical Education and Research
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