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Reference #:
2007-230
Inventors/Contributors
Jan van Deursen, Ph.D., Norman L. Eberhardt, Ph.D., Setsuya Sakagashira, M.D., Henry J. Hiddinga, Ph.D.
Description
We have replace the mouse islet amyloid polypeptide (IAPP, amylin) gene with the human IAPP gene. Human IAPP is readily converted to amyloid fibrils. Amyloids have been associated with a large number of human diseases that are associated with cell death. Mouse IAPP is non-amyloidogenic. By replacing the mouse IAPP with the human IAPP gene we have created a physiologic model of hman IAPP expression in the mouse, providing an idealized model system with which to study the influence of amyloid formation in the pathogenesis of type 2 diabetes. This model may be very useful for screening drugs that may be used to prevent and/or treat type 2 diabetes. A more detailed invention Description is attached to this disclosure.
Patent Status
None |
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Contact
Susan L. Stoddard, Ph.D., Licensing Manager
sstoddard@mayo.edu
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Mayo Foundation for Medical Education and Research
Office of Technology Commercialization
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Rochester, MN 55905
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Phone: (507) 284-1222
Fax: (507) 284-5410
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