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Reference #:
2007-288
Inventors/Contributors
Matthew J. Farrer, Ph.D., Heather L. Melrose, Ph.D., Sarah J. Lincoln
Description
Mice in which the endogenous leucine-rich repeat kinase 2 gene (LRRK2) has been ablated. Exon 41 has been flanked with loxP sites to alow Cre-mediated deletion. The region deleted contains the serion/threonine protein kinase catalytic domain. Splicing of exon 40 to 42 causes a frameshift mutation with the introduction of an early stop codon (TGA).
Patent Status
None |
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Contact
Susan L. Stoddard, Ph.D., Licensing Manager
sstoddard@mayo.edu
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Mayo Foundation for Medical Education and Research
Office of Technology Commercialization
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Rochester, MN 55905
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Phone: (507) 284-1222
Fax: (507) 284-5410
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