Inducible Tau Mice Expressing Human 4RON Tau With the P301L Mutation (termed iP301L)

Reference #:

2008-163

Inventors/Contributors

Jada M. Lewis, Ph.D.

Description

These mice conditionally express the human tau cDNA (4RON isoform) containing the FTDP-17 mutation (P301L) in exon 10. These mice utilize the tet-off system to express approximately 7X human tau in comparison to murine tau. Both the tTA transgene (Memory Pharmaceuticals) and the tau transgene (Mayo) must be present to yield expression of the human tau. Doxycycline in the diet of the mice repressed the human tau transgene. These mice develop pre-tangle pathology at approximately 12-15M and tangle pathology and neuronal loss by 20-24M. This is a good model of tauopathy in which to investigate factors which may accelerate tauopathy. It is a complementary model to rTg4510.

Patent Status

None