| Reference # |
Patent
Status |
Description |
| 2007-042 |
Pending
|
Abeta42 Lowering Agents that Inhibit Abeta Aggregation
Aggregation of Abeta42 is proposed to cause Alzheimers disease. Lowering Abeta42 production and preventing ...
|
| 2007-043 |
Pending
|
Enodgenous Wild Type BRI Peptides as Potential Therapeutic Compound for the Treatment and Prevention of AD
Amyloid beta peptide (Abeta) accumulation within senile plaques, cerebral blood vessels walls, and diffuse ...
|
| 2007-055 |
Pending
|
A Novel Synthetic Natriuretic Peptide, CU-NP
Heart failure is a major public health problem and is the leading cause of hospitalization in adults over 65 ...
|
| 2007-063 |
None
|
Tau Multimers as Therapeutic Target in Tauopathies
We define biochemical tau species, called tau multimers, in vivo both in mouse models of tauopathies and ...
|
| 2007-077 |
Pending
|
Selective and Irreversible Inhibitors of Insect AChEs for Pest Control: a New-Generation of Human-Safe and Effective Pesticides
This invention relates to invertebrate and insect-specific acetylcholinesterase (AChE) inhibitors, as well as ...
|
| 2007-106 |
None
|
Interaction of Alpha,Beta-dehydroalanine Containing Peptides with Amyloid-beta (Abeta) Peptides Involved in Alzheimer's Disease
The aggregates formed by a peptide called amyloid-beta(Abeta) in brain, are widely believed to be the main ...
|
| 2007-187 |
Pending
|
CD38 as a Target for Obesity, Metabolic Syndrome Related Disorders, and Dementia (Including Alzheimer's Disease)
Obesity is one of the major health problems of our times. Elucidating the signaling mechanisms by which high ...
|
| 2007-294 |
Pending
|
Small-Molecule Inhibitors of Ricin
Seeds from the castor bean plant, Ricinus communis, are poisonous to humans, animals, and insects. One of the ...
|
| 2006-024 |
Pending
|
Immunogenic Epitopes of the Human Folate Receptor Alpha
Breast and ovarian cancers overexpress the folate receptor alpha. We identified several epitopes to which ...
|
| 2006-060 |
Pending
|
New Source for Research and Therapeutic Cells from Apheresis Waste Products of Normal Donors
This invention describes a new source of cells for therapeutic and research use obtained as a by-product of ...
|
| 2006-079 |
Pending
|
Tranvesical Peritoneoscopy and Retroperitoneoscopy: The Urinary Tract as a Portal for Natural Orfice Surgery
A new approach to minimally invasive surgery involving access to the peritoneal cavity and retroperitoneum ...
|
| 2006-086 |
Pending
|
Programming the Polarity of the Immune Response in an Anitgen Independent Fashion
The acquired immune response is focused on specific antigens. Typically these antigens are discrete entities ...
|
| 2006-157 |
Pending
|
Superparamagnetic Cobalamin Analogs for the In Vitro and In Vivo Isolation, Localization and Destruction of Malignant Cells
A superparamagnetic nanoparticle of iron oxide is covalently bonded to Vitamin B12. The B-12-Iron oxide ...
|
| 2006-159 |
Pending
|
ABC-NP - - An Aquaretic and Natriuretic Peptide Without Vasodilatory Properties
The Natriuretic peptides (NP) are a naturally occurring family of peptides that increase salt excretion in ...
|
| 2006-194 |
Pending
|
Genetic Polymorphisms in the Human Serotonin Transporter (SLC6A4) Gene in Caucasian, African American, Han Chinese, and Mexican American Populations (Revised June 2007)
The SLC6A4 gene (also referred to as HTT, 5HTT, OCD1, SERT, 5-HTT, and hSERT) encodes an integral membrane ...
|
| 2006-241 |
Pending
|
Anti-Amyloid scFVs and Methods for Their Delivery to Treat or Prevent Alzheimer's Disease
Numerous pathological conditions including Alzheimer's Disease (AD) are associated with the deposition of ...
|
| 2006-243 |
None
|
Mayo Clinic Nicotine Depedence Education Program: Customized Workshops for Health-Care Professionals
A training program to teach health-care professionals how to effectively treat patients who use tobacco. The ...
|
| 2006-244 |
None
|
Your Path to Smokeless Tobacco Freedom Patient Manual, Facilitator's Guide, Illustrations, and DVD
Your Path to Smokeless Tobacco Freedom (Your Path) MC6013-01, is a new intervention booklet for patients who ...
|
| 2005-003 |
Pending
|
Use of SDF-1 and other CXCR4 Agonists to Antagonize TLR4
Toll-like receptor 4 (TLR4) transmits signals to various cells and in so doing can cause inflammation, the ...
|
| 2005-048 |
Pending
|
Use of Chaetocin and Related Compounds as Cancer Therapeutics
Chaetocin, a previously identified fungal byproduct, was found to kill cancer cells at low nanomolar drug ...
|
| 2005-108 |
Pending
|
Non-Abeta Based Amyloid Vaccines: Alternative Strategies to Promote Generic Anti-Amyloid Responses to Treat Alzheimer's Disease and Other Human Amyloidoses
Amyloid deposition is a process whereby a protein abnormally folds into an insoluble form. Various human ...
|
| 2005-112 |
None
|
My Path to a Smoke-Free Future - An Interactive Patient Manual
An interactive patient manual to assist the health care provider in delivering an effective intervention to ...
|
| 2005-123 |
Pending
|
RHIGM12 Recombinant Antibody
This invention relates to an antibody that can bind to and cross-link B7-DC polybeptides on the surface of a ...
|
| 2005-131 |
None
|
Facilitator's Guide and DVD for
A guide for the use of the patient intervention manual: "My Path to a Smoke Free Future". It contains ...
|
| 2005-141 |
Pending
|
Combination of Phosphodiesterase V Inhibition and Natriuretic Peptides for the Treatment of Cardiovascular and Renal Diseases
Combination of 2 types of drugs, phosphodiesterase V inhibitors and natriuretic peptides, to treat heart and ...
|
| 2005-165 |
Pending
|
Protease Inhibitors as Immune Adjuvants
The use of HIV protease inhibitors in HIV negative patients increases naive T cell production, which may be ...
|
| 2005-172 |
Pending
|
Small-Molecule Antidotes to Botulinum Neurotoxins Serotype A
Serotype selective and nonpeptidic inhibitors of botulinum neurotoxin serotype A (BoNTA) have been developed. ...
|
| 2005-210 |
Pending
|
Endogenous Agonist Mechanism of Action of Class B GPCRs, Key to Small Molecule Drug Development
We have identified a novel molecular mechanism of action of Class B GPCRs, a family that includes important ...
|
| 2005-215 |
Pending
|
Long Acting Atrial Natriuretic Peptide (LA-ANP)
LA-ANP is a novel Mayo developed peptide with potential use as a therapeutic agent in the treatment of heart ...
|
| 2005-277 |
None
|
Administration of Low Doses of Natriuretic Peptides to Improve Left Ventricular Remodeling after Myocardial Infarction
After a heart attack, the heart tries to repair itself and undergoes changes in its shape, structure and ...
|
| 2005-297 |
None
|
Targeting p120 Catenin Function to Block Tumor Growth and Metastasis
p120 catenin is a protein involved in holding cells together by promoting cell-cell adhesion. However, in ...
|
| 2004-004 |
Pending
|
Utility of PLVAP for Early Detection, Prognostic Prediction and Therapy of Liver and Other Cancers
Mayo Clinic researchers have produced antibodies against the protein product of a gene that is overexpressed ...
|
| 2004-011 |
Pending
|
Discovery and Identification of Naturally Processed and Presented HLA Class II Measles Vaccine Virus Peptides
Two measles vaccine virus-derived peptides, from the nucleoprotein (N peptide) and Phosphoprotein P peptide). ...
|
| 2004-068 |
Pending
|
Methods and Materials for Treating Digestive Motility Disorders
Methods and materials have been disclosed to increase the number of ICC (interstitial cells of Cajal) within ...
|
| 2004-152 |
Pending
|
Method of Preventing the Formation of Antibodies in Patients Undergoing Successive Treatments with Therapeutic Antibodies
This invention consists of methods and materials for reducing a mammal?s ability to produce antibodies ...
|
| 2004-224 |
Pending
|
Novel Anti-SARS Drugs: Small-Molecule Inhibitors of SARS Chymotrypsin-Like Cysteine Proteinase
Through in silico screening and NMR spectroscopic studies, we have discovered a group of drug-like molecules ...
|
| 2004-284 |
Pending
|
Inhibitors of Excision Repair as a Therapeutic to Prevent DNA Amplification Events
We have found that onset of neuronal toxicity in HD (Huntington's) may arise from cellular expansion of ...
|
| 2004-305 |
Pending
|
Preparation of Nanogold-VEGF Antibody Bioconjugates for Potential Anti-Angiogenic Therapy
In this invention we have prepared a number of nanobioconjugates comprising of gold nanoparticles and VEGF ...
|
| 2004-306 |
None
|
Preparation of Gold Nano Bioconjugates Comprising of Anticancer Drugs and Antiangiogenic Agent
(Patents logged on 05-019) In this invention we have prepared a number of nanobioconjugates comprising of ...
|
| 2003-032 |
Pending
|
Prevention and Intervention in Allergic Asthma Using B7-DC Cross-linking Antibody
Mayo Clinic researchers have developed a human monoclonal antibody that crosslinks the B7-DC receptor on ...
|
| 2003-089 |
Pending
|
Complexed Peptide and Adjuvant for Improved Vaccines
We have shown that peptides presented by major histocompatibility complex (MHC) class I molecules can be ...
|
| 2003-138 |
None
|
In vivo Models to Study PPARgamma and Protein Kinase C Signaling in Colon Cancer
Transgenic mice expressing levels of PKCbetaII in the colonic epithelium can be used as a model to assess the ...
|
| 2003-149 |
|
Proteomic Design and Chemical Synthesis of Amino Acids with High Blood-Brain Barrier Permeability
The present invention is the protemic design and chemical synthesis of amino acid polymers with improved ...
|
| 2003-220 |
Pending
|
A Method to Reconstitute the T Lymphocyte Compartment
Mayo Clinic researchers are developing therapeutic strategies to reconstitute the T lymphocyte compartment.
...
|
| 2002-017 |
Pending
|
A Peptide Vaccine to Induce Immunity to Epstein Barr Virus
A promiscuous T cell peptide epitope from the EBNA2 antigen has been identified. T cells induced with this ...
|
| 2002-062 |
None
|
Countermeasures to Anthrax
A group of chemical structures have been identified from in silico screening of a chemical database as ...
|
| 2002-077 |
None
|
Reducing the Gliding Resistance by Modification of Tendon Surface
Method to reduce gliding resistance and adhesion of tendon after tendon surgery by physical, chemical and ...
|
| 2002-180 |
None
|
Dominant Negative Inhibitor of Apoptosis Based on HIV Vpr
Apoptosis is a form of cell death that is abnormally regulated in a large variety of disease states. HIV Vpr ...
|
| 2002-181 |
Pending
|
Protease Inhibitors to Treat Stroke, Sepsis and Heart Attack
Apoptosis is a mechanism in cell death which is present in a large variety of human disease states including, ...
|
| 2002-225 |
Pending
|
Modulation of Toll-like Receptor 4 Signaling, or Other TLRs for Treatment or Prevention of Obesity and Excess Fat
Mayo Clinic researchers have identified the use of biological, pharmacological or saccharide intervention, ...
|
| 2002-226 |
Pending
|
Modulation of Toll-like Receptor 4 or Other TLRs for Treatment or Prevention of Bone Loss
Mayo Clinic researchers have identified the use of biological, pharmacological or saccharide intervention, ...
|
| 2002-244 |
Pending
|
Identification of the PKHDL1 Gene. A Receptor with Inducible T Lymphocyte Expression
Mayo Clinic has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in ...
|
| 2001-011 |
Pending
|
Trojan Antigen Vaccines
Vaccines designed to induce T-cell responses by delivering antigen into specialized cellular compartments of ...
|
| 2001-091 |
Pending
|
Regulation of Toll-like Receptors by Complex Saccharides
We have discovered that complex saccharides, specifically heparan sulfate glycosaminoglycans, signal cells ...
|
| 2001-098 |
Pending
|
Vaccine Platform for Mutable Viruses
Mayo Clinic researchers are developing a vaccine platform that addresses the challenge of viruses that ...
|
| 2001-099 |
|
Improved Bioartificial Liver for Extended Operation
This new bioartificial liver design will be used to increase the number of cells which can be utilized within ...
|
| 2001-124 |
Pending
|
Use of 3' Untranslated Regions to Confer Tumor Specific/Preferential Expression to Therapeutic Genes
It is possible to target RAS transformed tumor cells by post-transcriptional mRNA stabilization. The ...
|
| 2001-126 |
Pending
|
Antiparkinson Effects of a Novel Neurotensin Analog
The invention involves the use of a compound that activates brain receptors for neurotensin as a treatment ...
|
| 2001-152 |
|
Procter & Gamble Patent Portfolio - Colonic Delivery Technology
Technology portfolio related to Pharmaceutical Dosage Form for Colonic Delivery, Pharmaceutical Dosage Form ...
|
| 2001-155 |
Pending
|
Midodrine for Treatment of Psoriasis
Mayo Clinic researchers have identified a potential therapeutic role for midodrine HCL (ProAmatine) in the ...
|
| 2001-162 |
|
Potentiation of Immune Response Using Antibodies That Bind Dendritic Cells
An antibody has been discovered that binds mouse dendritic cells and potentiates their ability to induce ...
|
| 2000-024 |
None
|
Method for Detecting PNAs in a Biologic Sample
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 2000-028 |
|
Administering Mismatch PNAs to Modulate a Biologic Response
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 2000-029 |
|
Action of PNAs on DNA
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 2000-036 |
|
Triple Reuptake Inhibitors
Mayo Clinic researchers and their collaborators have developed novel small molecule triple reuptake ...
|
| 2000-080 |
|
Treatment of Neutrophil-Associated Pulmonary Diseases with Lidocaine
The treatment of neutrophil-associated pulmonary inflammation including chronic obstructive pulmonary disease ...
|
| 2000-090 |
|
Novel Small-molecule Antidepressants.
Mayo Clinic researchers and their collaborators have developed novel small molecule compounds that ...
|
| 2000-148 |
Pending
|
Improved Peptide Vaccines for Cancer that Stimulate Cytotoxic and Helper T Lymphocytes
Synthetic peptides containing epitopes recognized by both cytotoxic and T helper lymphocytes constitute ...
|
| 1999-061 |
Pending
|
Cellular Stent-Based Gene Delivery
This is a cell therapy delivery system which allows efficient and long term vascular delivery....
|
| 1999-087 |
Pending
|
Treatment of Eosinophil-Associated Pathologies by Signal Transduction Pathways
Compounds that modulate signal transduction such as lidocaine and other topical anesthetics for the treatment ...
|
| 1999-102 |
|
Antisense and Antigene Peptide Nucleic Acids as Tumor Agents (PNAs)
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 1998-066 |
|
Probiotic Mix of Bacteria and Yeast
The Mayo Clinic is developing and testing a synbiotic (composition of synergistic probiotic organisms and a ...
|
| 1998-076 |
|
Use of Botox-A in the Treatment of Cutaneous Wounds
Short term paralysis of underlying musculature to improve cutaneous wound healing in tramatic and ...
|
| 1998-106 |
None
|
Designing Transplant Organs, Tissues, and Cells to Minimize the Risk from Infectious Pathogens
This technology uses gene-based strategies to: (i) protect the transplant (organ, tissue, cells) from ...
|
| 1997-001 |
|
Use of Combined Growth Factor and Carrier Protein Therapy to Increase Bone Mass in Humans
With the aging of the population, osteoporosis is emerging as a major public health problem. Drugs used to ...
|
| 1997-053 |
|
Novel Oxime-Based Cholinesterase Reactivators as Antidotes for Organophosphates
An efficient and economical synthesis for novel oxime analogs yields analogs that are up to 100-fold more ...
|
| 1997-105 |
|
Use of Peptide Nucleic Acids (PNA's) to Turn off Gene Expression
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 1997-126 |
|
(L) - and (D) - Neo-Tryptophan - A Novel Amino Acid
L- and D-Neo-Tryptophan are unnatural amino acids that could be substituted for L- and D- isomers of the ...
|
| 1996-106 |
|
Bioprosthetic Heart Valve
Mayo has developed improved methods for making heart valves in order to slow heart valve degeneration....
|
| 1996-123 |
|
The Use of Topical Anesthetics and Glucocorticoids in Combination as a More Effective Treatment for Eosinophil-Related Diseases
Studies have shown that treatment of purified human eosinophils with a combination of lidocaine and ...
|
| 1996-124 |
|
Use of Sulfonylureas as a Treatment for Eosinophilic Disease
In vitro treatment of human eosinophils with various sulfonylureas inhibits cytokine-mediated eosinophil ...
|
| 1995-073 |
|
Synthesis of Novel Tacrine Analogs as Reversible, Potent and Selective Cholinesterase Inhibitors and Methods for their Use
An efficient and economical synthesis for novel, more lipophilic tacrine analogs has been developed. These ...
|
| 1994-112 |
|
Recombinant Human Interleukin-6 as a Treatment for Demyelinating Disease (Multiple Sclerosis)
Researchers utilize a murine model of multiple sclerosis induced by Theiler's virus to test the effect of ...
|
| 1993-001 |
|
Vasonatrin Peptide (VNP): Cardiovascular and Renal Actions
Synthetic peptide with blood pressure lowering and natriuretic actions. Brain natriuretic peptide (BNP) has ...
|
| 1993-094 |
|
Potential Treatment for cholangiocarcinomas
Somatostatin and its analogues may be useful in inhibiting the growth of cholangiocarcinoma in vivo....
|
| 1993-097 |
|
Phosphaturic Tumor Factor
An isolated and purified DNA sequence encoding hemangioma factor-1, HEM-1, has been identified that inhibits ...
|
| 1992-081 |
|
Treatment of Bronchial Asthma with Inhaled Lidocaine
A novel treatment for bronchial asthma.This therapy is based on the ability of lidocaine to block the ...
|
| 1988-032 |
|
Method For Gene Splicing By Using Overlap Extension (SOE)
A method is provided for joining two DNA molecules by first amplifying them by means of polymerase chain ...
|
| 1987-036A |
|
Method of Treating Immunopathologic Disorder Mediated by CD8+ T Cells
A method of treating an immunopathologic disorder, which is mediated by CD8+ phenotype T cells. Such ...
|
| 1987-036B |
None
|
Treatment of Neruologic Injury by Inhibiting Perforin
A method for treating neurologic injury in an individual, such as with multiple sclerosis, by administering ...
|
