| Reference # |
Patent
Status |
Description |
| 2009-012 |
Pending
|
Andenoviral Hexon Modifications to Reduce Liver Damage, Increase Virus Dosage, and Evade Neutralizing Antibodies
Blood factors bind hypervariable loops in adenvirus hexon and redirect adenovirus to the liver where it can ...
|
| 2009-034 |
Pending
|
Nanoparticle-Based Delivery of Therapeutic Peptides / Proteins for the Treatment of Human Disease (Also incorporates 2009-032 & 2009-033)
Enzyme replacement therapy (ERT) has been shown to be safe and effective for the treatment of several ...
|
| 2009-207 |
Pending
|
3D Transgene as an Inhibitor of Viral Infection
Mice that express the RNA-depleted RNA polymerase, 3D, from Theiler's murine encephalomyelitis virus (TMEV) ...
|
| 2009-217 |
Pending
|
Bile Acid Binding with Colesevelam Alone or in Combination with Measurement of 7alphaC4 in the Treatment of Functional Diarrhea, Chronic Diarrhea of Unknown Etiology, Post-Transplant Diarrhea, and Irritable Bowel Syndrome with Diarrhea
Patients with chronic diarrhea of unknown origin are suboptimally treated. We have identified a fasting ...
|
| 2009-338 |
Pending
|
Suppression of Amyloid Deposition in Alzheimer's Disease by Manipulating the Interleukin-6 Pathway on Microglia and Astrocytes
IL-6 enhances the phenotypic and immunnological activation of glia, do not prompt amyloid beta accumulation ...
|
| 2008-001 |
Pending
|
Single Cycle Replicating Adenovirus Vectors
Adenoviruses are used for gene therapy, vaccines, and cancer killing. For gene therapy and vaccine they are ...
|
| 2008-019 |
Pending
|
Human Monoclonal Antibodies Against Amyloid Beta Protein as a Therapeutic Agent for Alzheimer's Disease
Alzheimer's disease (AD) is the most common form of elderly dementia, and currently no effective treatment is ...
|
| 2008-128 |
Pending
|
Gastroduodenal Balloon Tube for Pancreatic Hypothermia with Nasal Piece and Jejunal Feedling Tube Extension
There is no treatment for acute pancreatitis which affects 250,000 people in the USA annually. Peritoneal ...
|
| 2008-142 |
Pending
|
HSV-2 Peptides for Stimulation of Cytotoxic T Lymphocytes
Optimal immunization with an antigen vaccine is achieved when both the antigen and the adjuvant are delivered ...
|
| 2008-144 |
Pending
|
Vaccines Against Antibiotics Resistance Genes
Antibiotics fail when pathogens acquire genes that confer resistance to these drugs. This invention proposes ...
|
| 2008-155 |
Pending
|
Prolonged Localized Hypothermia as a Treatment for Pancreatic Cancer
Pancreatic cancer (affecting 39,000 people annualy in the USA and 40,000 in Europe) typically presents at a ...
|
| 2008-347 |
Pending
|
Genetic Biomarker for Prediction of Response to Radiation Therapy
Genetic biomarkers for the prediction to response to radiation therapy have been discovered and are being ...
|
| 2008-375 |
Pending
|
Delayed Release Sodium Chenodeoxycholate Accelerates Colonic Transit and Increases Stool Frequency and Stool Consistency in Humans: A Novel Approach to Treating Constipation in Humans
The body produces bile salts in the liver, and these recirculate between the liver and intestine every day. ...
|
| 2007-030 |
Pending
|
Peptide Transfection Reagents for Non-Covalently Delivering Proteins and DNA into Human Mitochondria
Novel peptides have been designed to noncovalently bind proteins or nucleic acids and transport them into ...
|
| 2007-042 |
Pending
|
Abeta42 Lowering Agents that Inhibit Abeta Aggregation
Aggregation of Abeta42 is proposed to cause Alzheimers disease. Lowering Abeta42 production and preventing ...
|
| 2007-043 |
Pending
|
Enodgenous Wild Type BRI Peptides as Potential Therapeutic Compound for the Treatment and Prevention of AD
Amyloid beta peptide (Abeta) accumulation within senile plaques, cerebral blood vessels walls, and diffuse ...
|
| 2007-077 |
Pending
|
Selective and Irreversible Inhibitors of Insect AChEs for Pest Control: a New-Generation of Human-Safe and Effective Pesticides
This invention relates to invertebrate and insect-specific acetylcholinesterase (AChE) inhibitors, as well as ...
|
| 2007-187 |
Pending
|
CD38 as a Target for Obesity, Metabolic Syndrome Related Disorders, and Dementia (Including Alzheimer's Disease)
The protein CD38 is an enzyme that regulates cellular levels of nicotinamide adenine dinucleotide (NAD), ...
|
| 2007-222 |
Pending
|
IgM-Mediated Method of Receptor Clustering and Cell Modulation
Mayo researchers have developed a method for using an IgM or another multivalent molecule to cluster and cap ...
|
| 2007-248 |
Pending
|
MHC Class II Epitope Modification Strategies for Improved Generation of Antigen-Specific CD4 T Cells
Mayo Clinic researchers have developed epitope modifications that improve the immunogenicity of peptides by ...
|
| 2006-042 |
None
|
A System for Monitoring Ligand-dependent and Ligand-independent Androgen Receptor Activity
The androgen receptor is a protein that mediates androgen signaling in the body. In prostate cells, for ...
|
| 2006-079 |
Pending
|
Tranvesical Peritoneoscopy and Retroperitoneoscopy: The Urinary Tract as a Portal for Natural Orfice Surgery
A new approach to minimally invasive surgery involving access to the peritoneal cavity and retroperitoneum ...
|
| 2006-086 |
Pending
|
Programming the Polarity of the Immune Response in an Anitgen Independent Fashion
The acquired immune response is focused on specific antigens. Typically these antigens are discrete entities ...
|
| 2006-087 |
Pending
|
Prostaglandin-Pathway Gene Therapy
We have developed a gene therapy technology protocol that delivers genes for key enzymes in the prostaglandin ...
|
| 2006-115 |
Pending
|
Pan Anti-beta Amyloid scFVs, Anti-beta Amyloid scFVs Specific for Abeta-40 and Abeta-42 and Methods for Their Delivery to Treat or Prevent Alzheimer's Disease
Accumulation of Abeta in the brain of patients who suffer from Alzheimer?s disease (AD) triggers a complex ...
|
| 2006-123 |
Pending
|
Delivery of Biologically Active Antibodies into Human Cells by a Non-Covalently Attached Naturally Occurring Peptide Moiety
Novel peptides have been designed to noncovalently bind proteins or nucleic acids and transport them into ...
|
| 2006-159 |
Pending
|
ABC-NP - - An Aquaretic and Natriuretic Peptide Without Vasodilatory Properties
The natriuretic peptide family consists of natural hormones involved in the maintenance of fluid and sodium ...
|
| 2006-241 |
Pending
|
Anti-Amyloid scFVs and Methods for Their Delivery to Treat or Prevent Alzheimer's Disease
Numerous pathological conditions including Alzheimer's Disease (AD) are associated with the deposition of ...
|
| 2006-243 |
None
|
Mayo Clinic Nicotine Depedence Education Program: Customized Workshops for Health-Care Professionals
A training program to teach health-care professionals how to effectively treat patients who use tobacco. The ...
|
| 2006-244 |
None
|
Your Path to Smokeless Tobacco Freedom Patient Manual, Facilitator's Guide, Illustrations, and DVD
Your Path to Smokeless Tobacco Freedom (Your Path) MC6013-01, is a new intervention booklet for patients who ...
|
| 2005-048 |
Pending
|
Use of Chaetocin and Related Compounds as Cancer Therapeutics
Chaetocin, a previously identified fungal byproduct, was found to kill cancer cells at low nanomolar drug ...
|
| 2005-108 |
Pending
|
Non-Abeta Based Amyloid Vaccines: Alternative Strategies to Promote Generic Anti-Amyloid Responses to Treat Alzheimer's Disease and Other Human Amyloidoses
Aggregation and accumulation of amyloid b protein (Ab) plays a pivotal role in the development of Alzheimers ...
|
| 2005-112 |
None
|
My Path to a Smoke-Free Future - An Interactive Patient Manual
An interactive patient manual to assist the health care provider in delivering an effective intervention to ...
|
| 2005-123 |
Pending
|
RHIGM12 Recombinant Antibody
This invention relates to an antibody that can bind to and cross-link B7-DC polybeptides on the surface of a ...
|
| 2005-131 |
None
|
Facilitator's Guide and DVD for
A guide for the use of the patient intervention manual: "My Path to a Smoke Free Future". It contains ...
|
| 2005-141 |
Pending
|
Combination of Phosphodiesterase V Inhibition and Natriuretic Peptides for the Treatment of Cardiovascular and Renal Diseases
Combination of 2 types of drugs, phosphodiesterase V inhibitors and natriuretic peptides, to treat heart and ...
|
| 2005-165 |
Pending
|
Protease Inhibitors as Immune Adjuvants
The use of HIV protease inhibitors in HIV negative patients increases naive T cell production, which may be ...
|
| 2005-172 |
Pending
|
Small-Molecule Antidotes to Botulinum Neurotoxins Serotype A
Serotype selective and nonpeptidic inhibitors of botulinum neurotoxin serotype A (BoNTA) have been developed. ...
|
| 2005-210 |
Pending
|
Endogenous Agonist Mechanism of Action of Class B GPCRs, Key to Small Molecule Drug Development
We have identified a novel molecular mechanism of action of Class B GPCRs, a family that includes important ...
|
| 2005-215 |
Pending
|
Long Acting Atrial Natriuretic Peptide (LA-ANP)
The natriuretic peptide family consists of natural hormones involved in the maintenance of fluid and sodium ...
|
| 2005-237 |
|
Alternaria Antigen
A protein from the fungus alternaria which induces recruitment and activation of eosinophils.
...
|
| 2005-277 |
None
|
Administration of Low Doses of Natriuretic Peptides to Improve Left Ventricular Remodeling after Myocardial Infarction
After a heart attack, the heart tries to repair itself and undergoes changes in its shape, structure and ...
|
| 2004-004 |
Pending
|
Utility of PLVAP for Early Detection, Prognostic Prediction and Therapy of Liver and Other Cancers
Mayo Clinic researchers have produced antibodies against the protein product of a gene that is overexpressed ...
|
| 2004-011 |
|
Discovery and Identification of Naturally Processed and Presented HLA Class II Measles Vaccine Virus Peptides
Two measles vaccine virus-derived peptides, from the nucleoprotein (N peptide) and Phosphoprotein P peptide). ...
|
| 2004-068 |
Pending
|
Methods and Materials for Treating Digestive Motility Disorders
Methods and materials have been disclosed to increase the number of ICC (interstitial cells of Cajal) within ...
|
| 2004-152 |
Pending
|
Method of Preventing the Formation of Antibodies in Patients Undergoing Successive Treatments with Therapeutic Antibodies
This invention consists of methods and materials for reducing a mammal?s ability to produce antibodies ...
|
| 2004-224 |
Pending
|
Novel Anti-SARS Drugs: Small-Molecule Inhibitors of SARS Chymotrypsin-Like Cysteine Proteinase
Through in silico screening and NMR spectroscopic studies, we have discovered a group of drug-like molecules ...
|
| 2004-268 |
Pending
|
Somatostatin Analogs as Potential Therapeutic Treatment of Hepatic Polycystic Disease
Preclinical data suggests that somatostatin analogs may be useful in treating PKD....
|
| 2004-284 |
Pending
|
Inhibitors of Excision Repair as a Therapeutic to Prevent DNA Amplification Events
We have found that onset of neuronal toxicity in HD (Huntington's) may arise from cellular expansion of ...
|
| 2003-032 |
|
Prevention and Intervention in Allergic Asthma Using B7-DC Cross-linking Antibody
Mayo Clinic researchers have developed a human monoclonal antibody that crosslinks the B7-DC receptor on ...
|
| 2003-089 |
Pending
|
Complexed Peptide and Adjuvant for Improved Vaccines
We have shown that peptides presented by major histocompatibility complex (MHC) class I molecules can be ...
|
| 2003-149 |
|
Proteomic Design and Chemical Synthesis of Amino Acids with High Blood-Brain Barrier Permeability
The present invention is the protemic design and chemical synthesis of amino acid polymers with improved ...
|
| 2002-017 |
|
A Peptide Vaccine to Induce Immunity to Epstein Barr Virus
A promiscuous T cell peptide epitope from the EBNA2 antigen has been identified. T cells induced with this ...
|
| 2002-180 |
None
|
Dominant Negative Inhibitor of Apoptosis Based on HIV Vpr
Apoptosis is a form of cell death that is abnormally regulated in a large variety of disease states. HIV Vpr ...
|
| 2002-225 |
Pending
|
Modulation of Toll-like Receptor 4 Signaling, or Other TLRs for Treatment or Prevention of Obesity and Excess Fat
Mayo Clinic researchers have identified the use of biological, pharmacological or saccharide intervention, ...
|
| 2002-226 |
Pending
|
Modulation of Toll-like Receptor 4 or Other TLRs for Treatment or Prevention of Bone Loss
Mayo Clinic researchers have identified the use of biological, pharmacological or saccharide intervention, ...
|
| 2002-244 |
Pending
|
Identification of the PKHDL1 Gene. A Receptor with Inducible T Lymphocyte Expression
Mayo Clinic has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in ...
|
| 2001-091 |
Pending
|
Regulation of Toll-like Receptors by Complex Saccharides
We have discovered that complex saccharides, specifically heparan sulfate glycosaminoglycans, signal cells ...
|
| 2001-099 |
|
Improved Bioartificial Liver for Extended Operation
This new bioartificial liver design will be used to increase the number of cells which can be utilized within ...
|
| 2001-127 |
Pending
|
Treatment for Central Nervous System Disorders
Therapeutic compositions and methods for treating Alzheimer's disease have been developed whereby an ...
|
| 2001-152 |
|
Procter & Gamble Patent Portfolio - Colonic Delivery Technology
Technology portfolio related to Pharmaceutical Dosage Form for Colonic Delivery, Pharmaceutical Dosage Form ...
|
| 2001-155 |
Pending
|
Midodrine for Treatment of Psoriasis
A novel agent and formulation for treatment of psoriasis through a topical approach. Midodrine is a generic ...
|
| 2001-162 |
|
Potentiation of Immune Response Using Antibodies That Bind Dendritic Cells
An antibody has been discovered that binds mouse dendritic cells and potentiates their ability to induce ...
|
| 2000-001 |
|
A Transcriptionally Active Promoter-Gene System with Intrinsic Immunotherapeutic Benefit
The invention uses a constitutively active form of the Heat Shock Factor-1 (HSF-1) transcription factor to ...
|
| 2000-028 |
|
Administering Mismatch PNAs to Modulate a Biologic Response
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 2000-029 |
|
Action of PNAs on DNA
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 2000-080 |
|
Treatment of Neutrophil-Associated Pulmonary Diseases with Lidocaine
The treatment of neutrophil-associated pulmonary inflammation including chronic obstructive pulmonary disease ...
|
| 2000-148 |
Pending
|
Improved Peptide Vaccines for Cancer that Stimulate Cytotoxic and Helper T Lymphocytes
Synthetic peptides containing epitopes recognized by both cytotoxic and T helper lymphocytes constitute ...
|
| 1999-061 |
|
Cellular Stent-Based Gene Delivery
This is a cell therapy delivery system which allows efficient and long term vascular delivery....
|
| 1999-087 |
None
|
Treatment of Eosinophil-Associated Pathologies by Signal Transduction Pathways
Compounds that modulate signal transduction such as lidocaine and other topical anesthetics for the treatment ...
|
| 1998-009 |
|
Immunotherapy of Plasmaproliferative Disorders Utilizing an Antibody Engineered scFv
Multiple myeloma is a universally fatal plasmaproliferative disorder despite aggressive chemotherapy and ...
|
| 1998-066 |
|
Probiotic Mix of Bacteria and Yeast
The Mayo Clinic is developing and testing a synbiotic (composition of synergistic probiotic organisms and a ...
|
| 1998-076 |
|
Use of Botox-A in the Treatment of Cutaneous Wounds
Short term paralysis of underlying musculature to improve cutaneous wound healing in tramatic and ...
|
| 1997-001 |
|
Use of Combined Growth Factor and Carrier Protein Therapy to Increase Bone Mass in Humans
With the aging of the population, osteoporosis is emerging as a major public health problem. Drugs used to ...
|
| 1997-053 |
|
Novel Oxime-Based Cholinesterase Reactivators as Antidotes for Organophosphates
An efficient and economical synthesis for novel oxime analogs yields analogs that are up to 100-fold more ...
|
| 1997-105 |
|
Use of Peptide Nucleic Acids (PNA's) to Turn off Gene Expression
Peptide or polyamide nucleic acids (PNAs) are DNA analogs that hybridize to complementary nucleic sequences ...
|
| 1996-106 |
|
Bioprosthetic Heart Valve
Mayo has developed improved methods for making heart valves in order to slow heart valve degeneration....
|
| 1996-123 |
|
The Use of Topical Anesthetics and Glucocorticoids in Combination as a More Effective Treatment for Eosinophil-Related Diseases
Studies have shown that treatment of purified human eosinophils with a combination of lidocaine and ...
|
| 1996-124 |
|
Use of Sulfonylureas as a Treatment for Eosinophilic Disease
In vitro treatment of human eosinophils with various sulfonylureas inhibits cytokine-mediated eosinophil ...
|
| 1995-017 |
|
A Peptide Based Vaccine for Prevention and Cure of Rheumatoid Arthritis
Generation of synthetic peptides (15-20 amino acids) that will specifically bind to the major ...
|
| 1995-073 |
|
Synthesis of Novel Tacrine Analogs as Reversible, Potent and Selective Cholinesterase Inhibitors and Methods for their Use
An efficient and economical synthesis for novel, more lipophilic tacrine analogs has been developed. These ...
|
| 1994-112 |
|
Recombinant Human Interleukin-6 as a Treatment for Demyelinating Disease (Multiple Sclerosis)
Researchers utilize a murine model of multiple sclerosis induced by Theiler's virus to test the effect of ...
|
| 1993-001 |
|
Vasonatrin Peptide (VNP): Cardiovascular and Renal Actions
Synthetic peptide with blood pressure lowering and natriuretic actions. Brain natriuretic peptide (BNP) has ...
|
| 1993-094 |
|
Potential Treatment for cholangiocarcinomas
Somatostatin and its analogues may be useful in inhibiting the growth of cholangiocarcinoma in vivo....
|
| 1992-081 |
|
Treatment of Bronchial Asthma with Inhaled Lidocaine
A novel treatment for bronchial asthma.This therapy is based on the ability of lidocaine to block the ...
|
| 1988-032 |
|
Method For Gene Splicing By Using Overlap Extension (SOE)
A method is provided for joining two DNA molecules by first amplifying them by means of polymerase chain ...
|
| 1987-036A |
|
Method of Treating Immunopathologic Disorder Mediated by CD8+ T Cells
A method of treating an immunopathologic disorder, which is mediated by CD8+ phenotype T cells. Such ...
|
| 1987-036B |
|
Treatment of Neruologic Injury by Inhibiting Perforin
A method for treating neurologic injury in an individual, such as with multiple sclerosis, by administering ...
|
