Novel Oxime-Based Cholinesterase Reactivators as Antidotes for Organophosphates

Reference #:

1997-053

Inventors/Contributors

Yuan-Ping Pang, Ph.D., Stephen W. Brimijoin, Ph.D.

Description

An efficient and economical synthesis for novel oxime analogs yields analogs that are up to 100-fold more effective in reactivating the OFP-poisoned acetylcholinesterase than the standard clinical drug 2-pralidoxime. The analogs can be used as effective and economical antidotes for organophosphates poisoning, to treat accidental organophosphate-pesticide poisoning, and to counter actual and potential terrorist use of organophosphates.

Patent Status

	U.S. Patent Number 5,929,093 Issued July 27, 1999