(L) - and (D) - Neo-Tryptophan - A Novel Amino Acid

Reference #:

1997-126

Inventors/Contributors

Elliott Richelson M.D., Abdul H. Fauq Ph.D., Bernadette M. Cusack, Beth M. McMahon Ph.D., Daniel J. McCormick Ph.D., Yuan-Ping Pang Ph.D., Mona M. Boules Ph.D.

Description

L- and D-Neo-Tryptophan are unnatural amino acids that could be substituted for L- and D- isomers of the aromatic amino acid residues tryptophan, tyrosine, and phenylalanine. Neo-tryptophan-containing peptides may have novel characteristics including: increased biologic activity increased resistance to protease increased blood-brain-barrier permeability increased receptor binding affinity. Researchers have identified peptides that are therapeutic camdidates for the treatment of schizophrenia and other diseases.

Patent Status

	U.S. Patent Number 6,214,790 Issued April 10, 2001 U.S. Patent Number 6,765,099 Issued July 20, 2004 U.S. Patent Number 6,921,805 Issued July 26, 2005 U.S. Patent Number 7,098,307 Issued August 29, 2006