Identification of the PKHDL1 Gene. A Receptor with Inducible T Lymphocyte Expression

Reference #:

2002-244

Inventors/Contributors

Peter C. Harris Ph.D., Marie C. Hogan M.D., Christopher J. Ward

Description

Mayo Clinic has discovered a gene, PKHDL1, that shows significant homology to PKHD1 (the gene mutated in autosomal recessive polycystic kidney disease that was discovered at Mayo and for which a patent application is pending). The protein predicted to be encoded by PKHDL1, fibrocystin-L, is a large receptor-like protein that is highly expressed on T lymphocytes. The protein is postulated to be an important receptor with a role in T-cell proliferation, cytokine production, migration patterns, cytotoxicity and/or cell survival and is highly expressed on specific cancerous cells.

Patent Status

Pending