Method of Preventing the Formation of Antibodies in Patients Undergoing Successive Treatments with Therapeutic Antibodies

Reference #:

2004-152

Inventors/Contributors

William A. Faubion M.D., Stephen M. Ansell M.D., Ph.D., William J. Sandborn M.D.

Description

This invention consists of methods and materials for reducing a mammal’s ability to produce antibodies against a therapeutic polypeptide (or non-polypeptide molecule) to be administered to said mammal. The method includes (a) administering an antibody to the mammal, wherein the antibody binds to a B cell surface marker, thereby reducing the number of B cells capable of producing antibodies against the therapeutic polypeptide (or non-polypeptide molecule), and (b) administering the therapeutic polypeptide (or non-polypeptide molecule) to said mammal, wherein the therapeutic polypeptide (or non-polypeptide molecule) is different from the antibody.

Patent Status

Pending