|
Reference #:
2006-086
Inventors/Contributors
Larry R. Pease Ph.D.
Description
The acquired immune response is focused on specific antigens. Typically these antigens are discrete entities present in a complex structures comprised on cells or cell products. We have discovered a way to modify the immune response to antigens, even when the identity of the antigens is not known. This can be accomplished by using a proprietary method (B7-DC cross-linking) to activate dendritic cells, coated with antibody that can bind to and activate T cells, irrespective of the specificity of the T cells’ antigen receptors. The consequence is a shift in the responses elicited upon subsequent antigen exposure from a Th2 polarity (associated with allergy) toward Th1 polarity (associated with anti-viral or anti-tumor) immunity.
Patent Status
Pending |
|
Contact
Nathan L. Stacy, Licensing Manager
stacy.nathan@mayo.edu
|
|
Mayo Foundation for Medical Education and Research
Office of Technology Commercialization
Centerplace 4
200 First Street SW
Rochester, MN 55905
|
Phone: (507) 538-1652
Fax: (507) 284-5410
|
|
|
