Delivery of Biologically Active Antibodies into Human Cells by a Non-Covalently Attached Naturally Occurring Peptide Moiety

Reference #:

2006-123

Inventors/Contributors

Gobinda Sarkar, Ph.D., Mark E. Bolander, M.D., Deendayal Mandal, Ph.D., Eric W. Mahlum

Description

Novel peptides have been designed to noncovalently bind proteins or nucleic acids and transport them into nucleus, through both the cellular and nuclear membranes. Transported proteins include IgG, beta-galactosidase, and GFP. Transported nucleic acids include single stranded oligonucleotides and plasmid DNA. These peptides and methodologies suggest an ability to treat diseases with protein or nucleic acid modulation.

Patent Status

Pending