Peptide Transfection Reagents for Non-Covalently Delivering Proteins and DNA into Human Mitochondria

Reference #:

2007-030

Inventors/Contributors

Gobinda Sarkar, Ph.D., Eric Mahlum, Michael J. Yaszemski, M.D., Ph.D.

Description

Novel peptides have been designed to noncovalently bind proteins or nucleic acids and transport them into mitochondria, through both the cell membrane and the mitochondrial membrane. Transported proteins include IgG, beta-galactosidase, and GFP. Transported nucleic acids include single stranded oligonucleotides and plasmid DNA. These peptides and methodologies suggest an ability to target diseases caused by mitochondrial dysfunction.

Patent Status

Pending